We are analyzing https://link.springer.com/article/10.1007/s10238-021-00742-8.

Title:
RMI2 is a prognostic biomarker and promotes tumor growth in hepatocellular carcinoma | Clinical and Experimental Medicine
Description:
Genomic instability is a hallmark of all cancers. RMI2 is a crucial component of the BLM-TopoIIIa-RMI1-RMI2 complex that maintains genome stability. It has been shown to accelerate tumor progression in lung cancer, cervical cancer, and prostate cancer. However, its expression and function in hepatocellular carcinoma (HCC) remain poorly defined. In this study, gene expression data and corresponding clinical information of HCC were downloaded from the TCGA, ICGC, and GEO databases. The expression level and clinical significance of RMI2 in HCC were then analyzed. In addition, cellular and molecular biology experiments were conducted to explore the effects of silencing and overexpression of RMI2 on human liver cancer cells and the associated mechanisms. The results showed that RMI2 expression was elevated in HCC tissues. High expression of RMI2 was correlated with shorter survival and poor prognosis of patients. The results of CCK-8, Edu, and clonogenic assays confirmed that RMI2 overexpression promoted the proliferation of HCC cells. Flow cytometric analysis demonstrated that RMI2 overexpression enhanced G1-S phase transition and decreased apoptosis. Moreover, the protein expression of key effector molecules in the p53 signaling pathway was reduced following RMI2 overexpression. In summary, these results indicate that RMI2 promotes the growth of HCC cells and suppresses their apoptosis by inhibiting the p53 signaling pathway. This study provides new insights into the mechanisms driving HCC tumorigenesis and new therapeutic targets.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

article, google, scholar, cas, carcinoma, cancer, hepatocellular, rmi, cell, nat, rev, expression, hcc, data, liu, access, privacy, cookies, content, information, tumor, growth, complex, study, res, analysis, publish, search, clinical, prognostic, promotes, july, zhang, instability, genome, overexpression, liver, mechanisms, signaling, pathway, therapy, author, clin, dis, sorafenib, springer, log, journal, research, experimental,

Topics {✒️}

topo iiiα-rmi1-rmi2 complex blm-topoiiia-rmi1-rmi2 complex month download article/chapter pro-apoptotic sorafenib signaling synergistic anti-tumor activity molecular biology experiments dna helicase rtel1 dig liver dis p53 signaling pathway full article pdf privacy choices/manage cookies efficient cancer therapy nat rev cancer blm-dependent pathway hepatocellular carcinoma subclass hepatocellular carcinoma unresponsive related subjects integrated bioinformatic analysis promotes tumor growth experimental medicine aims regulate p53 activity annu rev pathol prognostic biomarkers cell death dis cell cycle proteins cancer genome instability cyclin-dependent kinase 2 cyclind1/cdk4 complex genome sequencing studies gene expression data clin cancer res european economic area remain poorly defined clonogenic assays confirmed da fonseca lg nucleic acids res tumour evolution 45s rdna repeats malignant solid tumors murine hepatocytes depends neuroendocrine prostate cancer conditions privacy policy socs1 blocks g1 targeting mutant p53 cell cycle transition key effector molecules rmi2 overexpression promoted ximing xu article li check access

Schema {🗺️}

WebPage:
      mainEntity:
         headline:RMI2 is a prognostic biomarker and promotes tumor growth in hepatocellular carcinoma
         description:Genomic instability is a hallmark of all cancers. RMI2 is a crucial component of the BLM-TopoIIIa-RMI1-RMI2 complex that maintains genome stability. It has been shown to accelerate tumor progression in lung cancer, cervical cancer, and prostate cancer. However, its expression and function in hepatocellular carcinoma (HCC) remain poorly defined. In this study, gene expression data and corresponding clinical information of HCC were downloaded from the TCGA, ICGC, and GEO databases. The expression level and clinical significance of RMI2 in HCC were then analyzed. In addition, cellular and molecular biology experiments were conducted to explore the effects of silencing and overexpression of RMI2 on human liver cancer cells and the associated mechanisms. The results showed that RMI2 expression was elevated in HCC tissues. High expression of RMI2 was correlated with shorter survival and poor prognosis of patients. The results of CCK-8, Edu, and clonogenic assays confirmed that RMI2 overexpression promoted the proliferation of HCC cells. Flow cytometric analysis demonstrated that RMI2 overexpression enhanced G1-S phase transition and decreased apoptosis. Moreover, the protein expression of key effector molecules in the p53 signaling pathway was reduced following RMI2 overexpression. In summary, these results indicate that RMI2 promotes the growth of HCC cells and suppresses their apoptosis by inhibiting the p53 signaling pathway. This study provides new insights into the mechanisms driving HCC tumorigenesis and new therapeutic targets.
         datePublished:2021-07-18T00:00:00Z
         dateModified:2021-07-18T00:00:00Z
         pageStart:229
         pageEnd:243
         sameAs:https://doi.org/10.1007/s10238-021-00742-8
         keywords:
            RMI2
            Hepatocellular carcinoma
            Prognosis
            Growth
            p53
            Internal Medicine
            Hematology
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig7_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig8_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig9_HTML.png
         isPartOf:
            name:Clinical and Experimental Medicine
            issn:
               1591-9528
            volumeNumber:22
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yue Li
               affiliation:
                     name:Renmin Hospital of Wuhan University
                     address:
                        name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaoqin He
               affiliation:
                     name:Renmin Hospital of Wuhan University
                     address:
                        name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaoyu Zhang
               affiliation:
                     name:Renmin Hospital of Wuhan University
                     address:
                        name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yangtao Xu
               affiliation:
                     name:Renmin Hospital of Wuhan University
                     address:
                        name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wenliang Chen
               affiliation:
                     name:Renmin Hospital of Wuhan University
                     address:
                        name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xin Liu
               affiliation:
                     name:Renmin Hospital of Wuhan University
                     address:
                        name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ximing Xu
               url:http://orcid.org/0000-0002-4240-5378
               affiliation:
                     name:Renmin Hospital of Wuhan University
                     address:
                        name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:RMI2 is a prognostic biomarker and promotes tumor growth in hepatocellular carcinoma
      description:Genomic instability is a hallmark of all cancers. RMI2 is a crucial component of the BLM-TopoIIIa-RMI1-RMI2 complex that maintains genome stability. It has been shown to accelerate tumor progression in lung cancer, cervical cancer, and prostate cancer. However, its expression and function in hepatocellular carcinoma (HCC) remain poorly defined. In this study, gene expression data and corresponding clinical information of HCC were downloaded from the TCGA, ICGC, and GEO databases. The expression level and clinical significance of RMI2 in HCC were then analyzed. In addition, cellular and molecular biology experiments were conducted to explore the effects of silencing and overexpression of RMI2 on human liver cancer cells and the associated mechanisms. The results showed that RMI2 expression was elevated in HCC tissues. High expression of RMI2 was correlated with shorter survival and poor prognosis of patients. The results of CCK-8, Edu, and clonogenic assays confirmed that RMI2 overexpression promoted the proliferation of HCC cells. Flow cytometric analysis demonstrated that RMI2 overexpression enhanced G1-S phase transition and decreased apoptosis. Moreover, the protein expression of key effector molecules in the p53 signaling pathway was reduced following RMI2 overexpression. In summary, these results indicate that RMI2 promotes the growth of HCC cells and suppresses their apoptosis by inhibiting the p53 signaling pathway. This study provides new insights into the mechanisms driving HCC tumorigenesis and new therapeutic targets.
      datePublished:2021-07-18T00:00:00Z
      dateModified:2021-07-18T00:00:00Z
      pageStart:229
      pageEnd:243
      sameAs:https://doi.org/10.1007/s10238-021-00742-8
      keywords:
         RMI2
         Hepatocellular carcinoma
         Prognosis
         Growth
         p53
         Internal Medicine
         Hematology
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig7_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig8_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10238-021-00742-8/MediaObjects/10238_2021_742_Fig9_HTML.png
      isPartOf:
         name:Clinical and Experimental Medicine
         issn:
            1591-9528
         volumeNumber:22
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yue Li
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
                     name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoqin He
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
                     name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoyu Zhang
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
                     name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yangtao Xu
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
                     name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wenliang Chen
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
                     name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xin Liu
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
                     name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ximing Xu
            url:http://orcid.org/0000-0002-4240-5378
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
                     name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Clinical and Experimental Medicine
      issn:
         1591-9528
      volumeNumber:22
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Renmin Hospital of Wuhan University
      address:
         name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
      name:Renmin Hospital of Wuhan University
      address:
         name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
      name:Renmin Hospital of Wuhan University
      address:
         name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
      name:Renmin Hospital of Wuhan University
      address:
         name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
      name:Renmin Hospital of Wuhan University
      address:
         name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
      name:Renmin Hospital of Wuhan University
      address:
         name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
      name:Renmin Hospital of Wuhan University
      address:
         name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yue Li
      affiliation:
            name:Renmin Hospital of Wuhan University
            address:
               name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Xiaoqin He
      affiliation:
            name:Renmin Hospital of Wuhan University
            address:
               name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Xiaoyu Zhang
      affiliation:
            name:Renmin Hospital of Wuhan University
            address:
               name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Yangtao Xu
      affiliation:
            name:Renmin Hospital of Wuhan University
            address:
               name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Wenliang Chen
      affiliation:
            name:Renmin Hospital of Wuhan University
            address:
               name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Xin Liu
      affiliation:
            name:Renmin Hospital of Wuhan University
            address:
               name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Ximing Xu
      url:http://orcid.org/0000-0002-4240-5378
      affiliation:
            name:Renmin Hospital of Wuhan University
            address:
               name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
      name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
      name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
      name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
      name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
      name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
      name:Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(111)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.03s.

LINK . SPRINGER . COM {}