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article, patients, google, scholar, renal, carcinoma, nomogram, cell, sarcomatoid, study, prognostic, validation, cancer, hou, zheng, survival, access, research, xian, zhang, urol, privacy, cookies, content, information, journal, yuan, database, development, metastatic, open, oncol, publish, search, guangdong, wang, srcc, seer, metastases, nephrectomy, model, int, clin, medical, hospital, author, springer, consent, data, standards,

Topics {✒️}

month download article/chapter web-based prediction model seer-based prognostic nomogram population-based study renal cell carcinoma small sample-sized study sarcomatoid renal carcinoma renal cell cancer seer-based study article international journal related subjects privacy choices/manage cookies full article pdf renal epithelial malignancies fuli wang national research committee clinical oncology aims open database predicting treatment outcomes article hou observed survival rate check access instant access jianlin yuan small bowel adenocarcinoma prognosis perform accurate predictions phase ii trial ethics declarations conflict conditions privacy policy established prognostic nomogram multivariable prognostic models retrospective cohort study european economic area nomogram-predicted probability pathological tumour characteristics la rochelle jc additional information publisher' journal finder publish effective prognostic nomogram training cohort consisted niuniu hou accepting optional cookies hispanic black patients current study constructed prognostic model comparable ethical standards seer database sarcomatoid dedifferentiation independent cohorts consisted

Questions {❓}

• Culp SH, Tannir NM, Abel EJ (2010) Can we better select patients with metastatic renal cell carcinoma for cytoreductive nephrectomy?
• Shuch B, Said J, La Rochelle JC (2009) Cytoreductive nephrectomy for kidney cancer with sarcomatoid histology—is up-front resection indicated and if not, is it avoidable?

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         headline:Construction and validation of a novel prognostic nomogram for patients with sarcomatoid renal cell carcinoma: a SEER-based study
         description:The only one established prognostic nomogram for patients with sarcomatoid renal cell carcinoma (sRCC) was based on a small sample-sized study without external validation, and a nomogram can be applied to western sRCC patients has not yet been developed. Therefore, our study aimed to construct and validate an effective nomogram to predict overall survival (OS) for these patients. The independent predictors for OS were identified and the nomogram was constructed on the basis of a retrospective study of a training cohort consisted of 428 non-Hispanic white sRCC patients registered in the Surveillance, Epidemiology and End Results (SEER) database from January 2010 to December 2015. Then, the discriminative performance of the nomogram was assessed by the concordance index (C-index). OS calibrations of the nomogram were also performed by comparing the nomogram-predicted probability to the observed survival rate. Furthermore, our nomogram was externally validated using two independent cohorts consisted of 71 non-Hispanic black patients and 82 Hispanic patients, respectively. Age at diagnosis, T stage, N stage, bone metastases, liver metastases, lung metastases and nephrectomy were identified as independent predictors for OS. In the training cohort and two validation cohorts, the C-indexes of the nomogram were 0.737, 0.801 and 0.764, respectively. Besides, excellent agreements between the nomogram prediction and the actual observation were achieved in all cohorts. The current study constructed and validated an effective prognostic nomogram for patients with sRCC, which can be used to perform accurate predictions of the 0.5-, 1-, and 2-year possibilities of OS.
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      headline:Construction and validation of a novel prognostic nomogram for patients with sarcomatoid renal cell carcinoma: a SEER-based study
      description:The only one established prognostic nomogram for patients with sarcomatoid renal cell carcinoma (sRCC) was based on a small sample-sized study without external validation, and a nomogram can be applied to western sRCC patients has not yet been developed. Therefore, our study aimed to construct and validate an effective nomogram to predict overall survival (OS) for these patients. The independent predictors for OS were identified and the nomogram was constructed on the basis of a retrospective study of a training cohort consisted of 428 non-Hispanic white sRCC patients registered in the Surveillance, Epidemiology and End Results (SEER) database from January 2010 to December 2015. Then, the discriminative performance of the nomogram was assessed by the concordance index (C-index). OS calibrations of the nomogram were also performed by comparing the nomogram-predicted probability to the observed survival rate. Furthermore, our nomogram was externally validated using two independent cohorts consisted of 71 non-Hispanic black patients and 82 Hispanic patients, respectively. Age at diagnosis, T stage, N stage, bone metastases, liver metastases, lung metastases and nephrectomy were identified as independent predictors for OS. In the training cohort and two validation cohorts, the C-indexes of the nomogram were 0.737, 0.801 and 0.764, respectively. Besides, excellent agreements between the nomogram prediction and the actual observation were achieved in all cohorts. The current study constructed and validated an effective prognostic nomogram for patients with sRCC, which can be used to perform accurate predictions of the 0.5-, 1-, and 2-year possibilities of OS.
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         Renal cell carcinoma
         Sarcomatoid
         Prognosis
         Nomogram
         SEER
         Oncology
         Surgical Oncology
         Cancer Research
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