We are analyzing https://link.springer.com/article/10.1007/s10072-020-04942-0.

Title:
Clinical features and management of coexisting anti-N-methyl-D-aspartate receptor encephalitis and myelin oligodendrocyte glycoprotein antibody–associated encephalomyelitis: a case report and review of the literature | Neurological Sciences
Description:
Background Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune encephalitis caused by antibodies targeting the GluN1 subunit of NMDA receptors. Myelin oligodendrocyte glycoprotein (MOG) antibody disorders are now widely accepted as peculiar neuroimmunological diseases with specific clinical and pathological features. Some rare cases of overlapping anti-NMDA receptor encephalitis and MOG antibody–associated diseases have been reported, presenting complex clinical symptoms that make the disease more difficult to recognize. Method In accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, the terms “NMDAR” and “MOG,” “NMDAR” and “demyelination,” and “MOG” and “encephalitis” were searched in PubMed. Clinical cases with dual-positive anti-NMDA cerebrospinal fluid receptors and MOG serum antibodies during the disease course were included in this study. Results A total of 25 patients were analyzed in this study. The age at onset ranged from 3 to 54 years. The median number of relapses was 2.8. Administration of intravenous methylprednisolone and immunoglobulin was the most widely used treatment strategy (19/25 patients). Second-line treatments such as administration of mycophenolate mofetil, rituximab, interferon-β, azathioprine, cyclophosphamide, and temozolomide were also reported, followed by good outcomes. Conclusions The rates of coexisting anti-NMDA receptor encephalitis and MOG antibody–associated encephalomyelitis may be underestimated. Clinical symptoms such as seizures and cognitive decline accompanied by atypical central nervous system demyelination serve as warning signs of possible coexisting anti-NMDA receptor encephalitis and MOG antibody–associated encephalomyelitis. These patients could achieve good outcomes under proper immunotherapies.
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Topics {✒️}

anti-n-methyl-d-aspartate receptor encephalitis anti-methyl-d-aspartate receptor encephalitis n-methyl-d-aspartate receptor n-methyl-d-aspartate month download article/chapter anti-nmda-receptor encephalitis anti-nmda receptor encephalitis anti-nmdar encephalitis combined concomitant anti-nmdar encephalitis anti-nmda receptor antibodies persistent mog-igg positivity myelin oligodendrocyte glycoprotein anti-mog cns demyelination antibody disorders concomitant anti-mog anti-nmdar encephalitis inflammatory demyelinating diseases full article pdf single-center cohort study myelin/oligodendroglial glycoprotein nmda receptor antibodies titulaer mj anti-nmdar concurrent mog antibody disease overlapping demyelinating syndrome privacy choices/manage cookies anti-nmdar antibodies swedish research council neuro-inflammatory diseases relapsing mog-igg recurrent cns demyelination overlapping demyelinating syndromes cns inflammatory diseases myelin basic protein neurological update cerebral cortical encephalitis pediatric autoimmune encephalitis receptor encephalitis related subjects natural science foundation code availability autoimmune encephalitis caused optic neuritis anti-nmda article nan additional information publisher european economic area preferred reporting items cognitive decline accompanied differential ultrastructural localization

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