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disease, article, stills, google, scholar, pubmed, adultonset, adult, medicine, patients, center, university, hospital, city, algeria, study, department, onset, cas, algiers, diagnostic, rheumatol, rheum, clinical, internal, algorithm, arthritis, aosd, rheumatology, criteria, fautrel, classification, points, bab, oued, analysis, research, daghorabbaci, central, semin, clin, data, nadia, fever, retrospective, author, ratio, springer, privacy, cookies,

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month download article/chapter salima lefkir-teffiani karima daghor-abbaci article daghor-abbaci chafia dahou makhloufi nested case–control study longitudinal prospective study present points-based score fatma zohra aissat tertiary internal medicine points-based score included case-control study full article pdf privacy choices/manage cookies farida mechid bilel bengana related subjects low glycosylated ferritin infectious diseases departments typical rash nadia ait hamadouche accepted manuscript version rheumatology classification criteria multicenter retrospective analysis el biar city el harrache city points-based score good diagnostic tool good diagnostic marquer reactive hemophagocytic syndrome holds exclusive rights nationwide epidemiological survery markers persistent pruritic eruptions rheumatism/american college persistent pruritic papules dichotomous view girard-madoux mh racial/ethnic variations ethics declarations disclosures check access instant access macrophage activation syndrome conditions privacy policy open-label suspected aosd based van pel mc clivati brandt hr author information authors infectious disease specialist

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         headline:Proposal of a new diagnostic algorithm for adult-onset Still’s disease
         description:This study was performed to develop a new diagnostic algorithm for adult-onset Still’s disease (AOSD). We conducted a multicenter prospective nationwide case–control study in tertiary Internal Medicine, Rheumatology, and Infectious Diseases departments, to include successively patients with suspected AOSD based on the presence of two or more major criteria of Yamaguchi and/or Fautrel classifications. Patients were classified as AOSD or controls according to a predefined procedure. A receiving operating characteristic curve was used to determine the best cutoff value of the points-based score for disease classification. A diagnostic algorithm was developed to help the physician in the diagnostic approach. A total of 160 patients were included, 80 patients with AOSD and 60 controls with different diagnoses. Twenty patients with incomplete data were excluded. In the multivariate analysis, 6 items remained independently associated with AOSD diagnosis: typical rash (OR: 24.01, 3 points), fever ≥ 39 °C (OR: 17.34, 3 points), pharyngitis (OR: 10.23, 2 points), arthritis (OR: 9.01, 2 points), NLR ≥ 4 (OR: 11.10, 2 points), and glycosylated ferritin ≤ 20% (OR: 1.59, 1 point). AOSD should be considered if the patient satisfies 7 points with a sensitivity of 92.5%, specificity of 93.3%, and accuracy of 92.8% (area under the curve (AUC): 0.97 [95% CI: 0.94–0.99]). The present points-based score was more accurate and sensitive than the Yamaguchi classification (78.8%, 92.5%, p = 0.01) and Fautrel classification (76.3%, 92.5%, p = 0.004). A typical rash associated with a points-based score ≥ 7 points leads to a very likely disease. The proposed new algorithm could be a good diagnostic tool for adult-onset Still’s disease in clinical practice and research.
         datePublished:2023-01-25T00:00:00Z
         dateModified:2023-01-25T00:00:00Z
         pageStart:1125
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         sameAs:https://doi.org/10.1007/s10067-023-06509-8
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            Classification criteria
            Diagnostic algorithm
            Glycosylated ferritin
            Neutrophil-to-lymphocyte ratio
            Typical rash
            Rheumatology
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      headline:Proposal of a new diagnostic algorithm for adult-onset Still’s disease
      description:This study was performed to develop a new diagnostic algorithm for adult-onset Still’s disease (AOSD). We conducted a multicenter prospective nationwide case–control study in tertiary Internal Medicine, Rheumatology, and Infectious Diseases departments, to include successively patients with suspected AOSD based on the presence of two or more major criteria of Yamaguchi and/or Fautrel classifications. Patients were classified as AOSD or controls according to a predefined procedure. A receiving operating characteristic curve was used to determine the best cutoff value of the points-based score for disease classification. A diagnostic algorithm was developed to help the physician in the diagnostic approach. A total of 160 patients were included, 80 patients with AOSD and 60 controls with different diagnoses. Twenty patients with incomplete data were excluded. In the multivariate analysis, 6 items remained independently associated with AOSD diagnosis: typical rash (OR: 24.01, 3 points), fever ≥ 39 °C (OR: 17.34, 3 points), pharyngitis (OR: 10.23, 2 points), arthritis (OR: 9.01, 2 points), NLR ≥ 4 (OR: 11.10, 2 points), and glycosylated ferritin ≤ 20% (OR: 1.59, 1 point). AOSD should be considered if the patient satisfies 7 points with a sensitivity of 92.5%, specificity of 93.3%, and accuracy of 92.8% (area under the curve (AUC): 0.97 [95% CI: 0.94–0.99]). The present points-based score was more accurate and sensitive than the Yamaguchi classification (78.8%, 92.5%, p = 0.01) and Fautrel classification (76.3%, 92.5%, p = 0.004). A typical rash associated with a points-based score ≥ 7 points leads to a very likely disease. The proposed new algorithm could be a good diagnostic tool for adult-onset Still’s disease in clinical practice and research.
      datePublished:2023-01-25T00:00:00Z
      dateModified:2023-01-25T00:00:00Z
      pageStart:1125
      pageEnd:1135
      sameAs:https://doi.org/10.1007/s10067-023-06509-8
      keywords:
         Adult-onset Still’s disease
         Classification criteria
         Diagnostic algorithm
         Glycosylated ferritin
         Neutrophil-to-lymphocyte ratio
         Typical rash
         Rheumatology
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