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Title:
Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort | Clinical Rheumatology
Description:
The aim of this study was to determine the association of anti-Sm antibodies with clinical manifestations, comorbidities, and disease damage in a large multi-ethnic SLE cohort. SLE patients (per American College of Rheumatology criteria), age â„16 years, disease duration â€10 years at enrollment, and defined ethnicity (African American, Hispanic or Caucasian), from a longitudinal US cohort were studied. Socioeconomic-demographic features, cumulative clinical manifestations, comorbidities, and disease damage (as per the Systemic Lupus International Collaborating Clinics Damage Index [SDI]) were determined. The association of anti-Sm antibodies with clinical features was examined using multivariable logistic regression analyses adjusting for age, gender, ethnicity, disease duration, level of education, health insurance, and smoking. A total of 2322 SLE patients were studied. The mean (standard deviation, SD) age at diagnosis was 34.4 (12.8) years and the mean (SD) disease duration was 9.0â(7.9)âyears; 2127 (91.6 %) were women. Anti-Sm antibodies were present in 579 (24.9 %) patients. In the multivariable analysis, anti-Sm antibodies were significantly associated with serositis, renal involvement, psychosis, vasculitis, Raynaudâs phenomenon, hemolytic anemia, leukopenia, lymphopenia, and arterial hypertension. No significant association was found for damage accrual. In this cohort of SLE patients, anti-Sm antibodies were associated with several clinical features including serious manifestations such as renal, neurologic, and hematologic disorders as well as vasculitis.
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Keywords {đ}
lupus, article, systemic, pubmed, google, scholar, erythematosus, clinical, cas, antibodies, patients, antism, rheum, autoantibodies, arthritis, disease, rheumatol, rheumatology, university, cohort, damage, medicine, usa, alarcĂłn, association, features, central, clin, birmingham, analysis, manifestations, sle, health, autoantibody, privacy, cookies, content, research, profile, mcgwin, petri, reveille, vilĂĄ, study, american, center, division, department, publish, search,
Topics {âïž}
month download article/chapter multi-ethnic lupus cohort anti-ro/la antibodies article arroyo-ĂĄvila macrophage activation syndrome skin diseases igg anti-sm antibodies full article pdf lĂłpez-gĂłmez jm research group registry anti-smith antibodies yesenia santiago-casas & luis privacy choices/manage cookies systemic lupus erythematosus systemic lupus erythematosus nature versus nurture extractable nuclear antigens aguilar leĂłn de rosalind ramsey-goldman acute confusional state multiethnic lupus cohort negrete-garcĂa mc adult-onset patients lupus nephritis unrestricted educational grant american blacks compared cumulative clinical manifestations gerald mcgwin jr anti-c1q antibodies yesenia santiago-casas autoantibody associations depend anti-sm antibodies anti-sm antibodies] rheumatology revised criteria european economic area davis js 4th european working party glomerular immune deposits routine diagnostic test puerto rico [upr] institutional review board anti-sm antibody retrospective observational study clinical features including conditions privacy policy anti-u1-rnp function-based classification meno garcĂa ac sm antibody titers specific antinuclear antibodies
Questions {â}
- To CH, Petri M (2005) Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus?
- TĂĄpanes FJ, VĂĄsquez M, RamĂrez R, Matheus C, RodrĂguez MA, Bianco N (2000) Cluster analysis of antinuclear autoantibodies in the prognosis of SLE nephropathy: are anti-extractable nuclear antibodies protective?
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headline:Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort
description:The aim of this study was to determine the association of anti-Sm antibodies with clinical manifestations, comorbidities, and disease damage in a large multi-ethnic SLE cohort. SLE patients (per American College of Rheumatology criteria), age â„16 years, disease duration â€10 years at enrollment, and defined ethnicity (African American, Hispanic or Caucasian), from a longitudinal US cohort were studied. Socioeconomic-demographic features, cumulative clinical manifestations, comorbidities, and disease damage (as per the Systemic Lupus International Collaborating Clinics Damage Index [SDI]) were determined. The association of anti-Sm antibodies with clinical features was examined using multivariable logistic regression analyses adjusting for age, gender, ethnicity, disease duration, level of education, health insurance, and smoking. A total of 2322 SLE patients were studied. The mean (standard deviation, SD) age at diagnosis was 34.4 (12.8) years and the mean (SD) disease duration was 9.0â(7.9)âyears; 2127 (91.6 %) were women. Anti-Sm antibodies were present in 579 (24.9 %) patients. In the multivariable analysis, anti-Sm antibodies were significantly associated with serositis, renal involvement, psychosis, vasculitis, Raynaudâs phenomenon, hemolytic anemia, leukopenia, lymphopenia, and arterial hypertension. No significant association was found for damage accrual. In this cohort of SLE patients, anti-Sm antibodies were associated with several clinical features including serious manifestations such as renal, neurologic, and hematologic disorders as well as vasculitis.
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Rheumatology
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headline:Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort
description:The aim of this study was to determine the association of anti-Sm antibodies with clinical manifestations, comorbidities, and disease damage in a large multi-ethnic SLE cohort. SLE patients (per American College of Rheumatology criteria), age â„16 years, disease duration â€10 years at enrollment, and defined ethnicity (African American, Hispanic or Caucasian), from a longitudinal US cohort were studied. Socioeconomic-demographic features, cumulative clinical manifestations, comorbidities, and disease damage (as per the Systemic Lupus International Collaborating Clinics Damage Index [SDI]) were determined. The association of anti-Sm antibodies with clinical features was examined using multivariable logistic regression analyses adjusting for age, gender, ethnicity, disease duration, level of education, health insurance, and smoking. A total of 2322 SLE patients were studied. The mean (standard deviation, SD) age at diagnosis was 34.4 (12.8) years and the mean (SD) disease duration was 9.0â(7.9)âyears; 2127 (91.6 %) were women. Anti-Sm antibodies were present in 579 (24.9 %) patients. In the multivariable analysis, anti-Sm antibodies were significantly associated with serositis, renal involvement, psychosis, vasculitis, Raynaudâs phenomenon, hemolytic anemia, leukopenia, lymphopenia, and arterial hypertension. No significant association was found for damage accrual. In this cohort of SLE patients, anti-Sm antibodies were associated with several clinical features including serious manifestations such as renal, neurologic, and hematologic disorders as well as vasculitis.
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Rheumatology
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