We are analyzing https://link.springer.com/article/10.1007/s10067-015-2922-1.

Title:
Serum microRNAs as Potential Biomarkers of Juvenile Idiopathic Arthritis | Clinical Rheumatology
Description:
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression of targeted mRNAs, which are important in the pathogenesis of autoimmune diseases. MiRNAs may have the potential to serve as biomarkers of disease. We evaluated serum levels of selected miRNAs and their associations with disease activity in juvenile idiopathic arthritis (JIA). Sera and peripheral blood leukocytes were collected from patients with JIA (8 systemic onset, 16 polyarthritis) and healthy controls. Levels of miR-16, miR-132, miR-146a, miR-155, and miR-223 were quantified. Levels of miR-223 in sera were significantly higher in patients in the active phase of systemic onset JIA than in controls. MiRNAs of peripheral blood leukocytes did not exhibit any difference between patients with JIA and controls. In both systemic onset JIA and polyarthritis patients, levels of miR-223 and miR-16 correlated with erythrocyte sedimentation rate and matrix metalloproteinase-3, respectively. MiR-146a and miR-223 in polyarthritis showed correlations with matrix metalloproteinase-3. Expressions of miRNAs were altered in patients with JIA. Serum levels of miR-223 may be a potential disease biomarker. Investigation of miRNAs could be helpful in understanding the pathogenesis of JIA and could aid in the identification of additional disease biomarkers.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

article, pubmed, arthritis, google, scholar, cas, juvenile, idiopathic, micrornas, rheumatoid, rheum, central, biomarkers, patients, serum, jia, systemic, microrna, potential, mirnas, disease, levels, access, wang, zhang, privacy, cookies, content, ito, expression, diseases, dis, gay, data, publish, search, rheumatology, kawada, kawano, iwata, martini, ann, author, rev, chen, res, chan, information, log, journal,

Topics {✒️}

month download article/chapter sensitive pcr-based quantitation nf-kappab-dependent induction stable blood-based markers juvenile idiopathic arthritis juvenile rheumatoid arthritis full article pdf o'briant kc early rheumatoid arthritis cell-free circulating micrornas upregulated mir-146a expression privacy choices/manage cookies post-transcriptional regulation related subjects tiny rna world coding rnas myeloid-related proteins 8 collagen-induced arthritis rheumatoid arthritis patients peripheral blood leukocytes article kamiya systemic onset jia s100a12 serum concentrations potential diagnostic biomarkers european economic area erythrocyte sedimentation rate cyclic citrullinated peptide monitoring neutrophil activation pogosova-agadjanyan el dominguez-gutierrez pr lentivirus-mediated silencing author information authors rheumatoid arthritis article log conditions privacy policy check access instant access innate immune responses additional disease biomarkers 1-2 osakada morioka-cho evaluated serum levels regulate gene expression yoshinori ito plasma microrna expressions microrna-mediated regulation accepting optional cookies chan ek systemic rheumatic diseases jun-ichi kawada polyarthritis showed correlations

Questions {❓}

Duroux-Richard I, Jorgensen C, Apparailly F (2012) What do microRNAs mean for rheumatoid arthritis?
Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Serum microRNAs as Potential Biomarkers of Juvenile Idiopathic Arthritis
         description:MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression of targeted mRNAs, which are important in the pathogenesis of autoimmune diseases. MiRNAs may have the potential to serve as biomarkers of disease. We evaluated serum levels of selected miRNAs and their associations with disease activity in juvenile idiopathic arthritis (JIA). Sera and peripheral blood leukocytes were collected from patients with JIA (8 systemic onset, 16 polyarthritis) and healthy controls. Levels of miR-16, miR-132, miR-146a, miR-155, and miR-223 were quantified. Levels of miR-223 in sera were significantly higher in patients in the active phase of systemic onset JIA than in controls. MiRNAs of peripheral blood leukocytes did not exhibit any difference between patients with JIA and controls. In both systemic onset JIA and polyarthritis patients, levels of miR-223 and miR-16 correlated with erythrocyte sedimentation rate and matrix metalloproteinase-3, respectively. MiR-146a and miR-223 in polyarthritis showed correlations with matrix metalloproteinase-3. Expressions of miRNAs were altered in patients with JIA. Serum levels of miR-223 may be a potential disease biomarker. Investigation of miRNAs could be helpful in understanding the pathogenesis of JIA and could aid in the identification of additional disease biomarkers.
         datePublished:2015-04-07T00:00:00Z
         dateModified:2015-04-07T00:00:00Z
         pageStart:1705
         pageEnd:1712
         sameAs:https://doi.org/10.1007/s10067-015-2922-1
         keywords:
            Biological agents
            Juvenile idiopathic arthritis
            micro RNAs
            miR-146
            miR-155
            Rheumatology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10067-015-2922-1/MediaObjects/10067_2015_2922_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10067-015-2922-1/MediaObjects/10067_2015_2922_Fig2_HTML.gif
         isPartOf:
            name:Clinical Rheumatology
            issn:
               1434-9949
               0770-3198
            volumeNumber:34
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer London
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yasuko Kamiya
               affiliation:
                     name:Nagoya University Graduate School of Medicine
                     address:
                        name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jun-ichi Kawada
               affiliation:
                     name:Nagoya University Graduate School of Medicine
                     address:
                        name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yoshihiko Kawano
               affiliation:
                     name:Nagoya University Graduate School of Medicine
                     address:
                        name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yuka Torii
               affiliation:
                     name:Nagoya University Graduate School of Medicine
                     address:
                        name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shinji Kawabe
               affiliation:
                     name:Aichi Children’s Health and Medical Center
                     address:
                        name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Naomi Iwata
               affiliation:
                     name:Aichi Children’s Health and Medical Center
                     address:
                        name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yoshinori Ito
               affiliation:
                     name:Nagoya University Graduate School of Medicine
                     address:
                        name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Serum microRNAs as Potential Biomarkers of Juvenile Idiopathic Arthritis
      description:MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression of targeted mRNAs, which are important in the pathogenesis of autoimmune diseases. MiRNAs may have the potential to serve as biomarkers of disease. We evaluated serum levels of selected miRNAs and their associations with disease activity in juvenile idiopathic arthritis (JIA). Sera and peripheral blood leukocytes were collected from patients with JIA (8 systemic onset, 16 polyarthritis) and healthy controls. Levels of miR-16, miR-132, miR-146a, miR-155, and miR-223 were quantified. Levels of miR-223 in sera were significantly higher in patients in the active phase of systemic onset JIA than in controls. MiRNAs of peripheral blood leukocytes did not exhibit any difference between patients with JIA and controls. In both systemic onset JIA and polyarthritis patients, levels of miR-223 and miR-16 correlated with erythrocyte sedimentation rate and matrix metalloproteinase-3, respectively. MiR-146a and miR-223 in polyarthritis showed correlations with matrix metalloproteinase-3. Expressions of miRNAs were altered in patients with JIA. Serum levels of miR-223 may be a potential disease biomarker. Investigation of miRNAs could be helpful in understanding the pathogenesis of JIA and could aid in the identification of additional disease biomarkers.
      datePublished:2015-04-07T00:00:00Z
      dateModified:2015-04-07T00:00:00Z
      pageStart:1705
      pageEnd:1712
      sameAs:https://doi.org/10.1007/s10067-015-2922-1
      keywords:
         Biological agents
         Juvenile idiopathic arthritis
         micro RNAs
         miR-146
         miR-155
         Rheumatology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10067-015-2922-1/MediaObjects/10067_2015_2922_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10067-015-2922-1/MediaObjects/10067_2015_2922_Fig2_HTML.gif
      isPartOf:
         name:Clinical Rheumatology
         issn:
            1434-9949
            0770-3198
         volumeNumber:34
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer London
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yasuko Kamiya
            affiliation:
                  name:Nagoya University Graduate School of Medicine
                  address:
                     name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jun-ichi Kawada
            affiliation:
                  name:Nagoya University Graduate School of Medicine
                  address:
                     name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yoshihiko Kawano
            affiliation:
                  name:Nagoya University Graduate School of Medicine
                  address:
                     name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuka Torii
            affiliation:
                  name:Nagoya University Graduate School of Medicine
                  address:
                     name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shinji Kawabe
            affiliation:
                  name:Aichi Children’s Health and Medical Center
                  address:
                     name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Naomi Iwata
            affiliation:
                  name:Aichi Children’s Health and Medical Center
                  address:
                     name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yoshinori Ito
            affiliation:
                  name:Nagoya University Graduate School of Medicine
                  address:
                     name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Clinical Rheumatology
      issn:
         1434-9949
         0770-3198
      volumeNumber:34
Organization:
      name:Springer London
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Nagoya University Graduate School of Medicine
      address:
         name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
         type:PostalAddress
      name:Nagoya University Graduate School of Medicine
      address:
         name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
         type:PostalAddress
      name:Nagoya University Graduate School of Medicine
      address:
         name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
         type:PostalAddress
      name:Nagoya University Graduate School of Medicine
      address:
         name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
         type:PostalAddress
      name:Aichi Children’s Health and Medical Center
      address:
         name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
         type:PostalAddress
      name:Aichi Children’s Health and Medical Center
      address:
         name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
         type:PostalAddress
      name:Nagoya University Graduate School of Medicine
      address:
         name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yasuko Kamiya
      affiliation:
            name:Nagoya University Graduate School of Medicine
            address:
               name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
               type:PostalAddress
            type:Organization
      name:Jun-ichi Kawada
      affiliation:
            name:Nagoya University Graduate School of Medicine
            address:
               name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
               type:PostalAddress
            type:Organization
      name:Yoshihiko Kawano
      affiliation:
            name:Nagoya University Graduate School of Medicine
            address:
               name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
               type:PostalAddress
            type:Organization
      name:Yuka Torii
      affiliation:
            name:Nagoya University Graduate School of Medicine
            address:
               name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
               type:PostalAddress
            type:Organization
      name:Shinji Kawabe
      affiliation:
            name:Aichi Children’s Health and Medical Center
            address:
               name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
               type:PostalAddress
            type:Organization
      name:Naomi Iwata
      affiliation:
            name:Aichi Children’s Health and Medical Center
            address:
               name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
               type:PostalAddress
            type:Organization
      name:Yoshinori Ito
      affiliation:
            name:Nagoya University Graduate School of Medicine
            address:
               name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
      name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
      name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
      name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
      name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
      name:Department of Infection and Immunology, Aichi Children’s Health and Medical Center, Obu, Japan
      name:Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(145)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.78s.

LINK . SPRINGER . COM {}