We are analyzing https://link.springer.com/article/10.1007/s10059-013-2298-5.

Title:
Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1 | Molecules and Cells
Description:
Berberine (BBR) is one of the major alkaloids and has been reported to have a variety of pharmacologic effects, including inhibition of cell cycle progression. Here, we investigated the mechanisms of BBR protection of neuronal cells from cell death induced by the Parkinson’s disease-related neurotoxin 6-hydroxydopamine (6-OHDA). Pretreatment of SH-SY5Y cells with BBR significantly reduced 6-OHDAinduced generation of reactive oxygen species (ROS), caspase-3 activation, and subsequent cell death. BBR also upregulated heme oxygenase-1 (HO-1) expression, which conferred protection against 6-OHDA-induced dopaminergic neuron injury and besides, effect of BBR on HO-1 was reversed by siRNA-Nrf2. Furthermore, BBR induced PI3K/Akt and p38 activation, which are involved in the induction of Nrf2 expression and neuroprotection. These results suggest that BBR may be useful as a therapeutic agent for the treatment of dopaminergic neuronal diseases.
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Keywords {🔍}

article, pubmed, google, scholar, cas, heme, oxygenase, cells, berberine, cell, lee, stress, expression, nrf, oxidative, bbr, pathway, chen, human, dopaminergic, induction, activation, biochem, privacy, cookies, content, death, induced, parkinsons, access, alam, response, pharm, publish, research, search, protects, neuronal, kim, kyung, jin, related, disease, regulation, gene, transcription, factor, chem, wang, res,

Topics {✒️}

phosphatidylinositol 3-kinase/akt-dependent mechanism phosphatidylinositol 3-kinase/akt pathway month download article/chapter 6-hydroxydopamine-induced oxidative stress disease-related neurotoxin 6-hydroxydopamine 6-hydroxydopamine-derived oxidative stress src-mediated tyrosine phosphorylation kyung jin lee cell death induced human dopaminergic cells bbr induced pi3k/akt subsequent cell death iii drug metabolism/transport dopaminergic neuronal diseases cyclopentenone prostaglandin 15-deoxy-delta12 human mesangial cells transcription factor nrf2 nrf2 transcription factor heme oxygenase-1 expression collar transcription factor heme oxygenase-1 gene upregulated heme oxygenase-1 targeting heme oxygenase-1 pi3k signaling pathways cell damage induced ginsenoside rb1 protects full article pdf privacy choices/manage cookies haem oxygenase-1 gene cell cycle progression antioxidant-responsive element inhibiting oxidative stress oxidative stress suppression p38/nrf2 pathway erk/ nrf2 pathways neuronal cells nsc34 motor neuron sh-sy5y cells lung endothelial cells hyperoxia-induced activation stress response elements 6-ohda induced parkinson antioxidant phytochemical carnosol cells jinbum bae nrf-2/ho-1 pathway dihydropyrimidine dehydrogenase expression cell tissue res adaptive survival response heme oxygenase-1 european economic area

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         headline:Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1
         description:Berberine (BBR) is one of the major alkaloids and has been reported to have a variety of pharmacologic effects, including inhibition of cell cycle progression. Here, we investigated the mechanisms of BBR protection of neuronal cells from cell death induced by the Parkinson’s disease-related neurotoxin 6-hydroxydopamine (6-OHDA). Pretreatment of SH-SY5Y cells with BBR significantly reduced 6-OHDAinduced generation of reactive oxygen species (ROS), caspase-3 activation, and subsequent cell death. BBR also upregulated heme oxygenase-1 (HO-1) expression, which conferred protection against 6-OHDA-induced dopaminergic neuron injury and besides, effect of BBR on HO-1 was reversed by siRNA-Nrf2. Furthermore, BBR induced PI3K/Akt and p38 activation, which are involved in the induction of Nrf2 expression and neuroprotection. These results suggest that BBR may be useful as a therapeutic agent for the treatment of dopaminergic neuronal diseases.
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      description:Berberine (BBR) is one of the major alkaloids and has been reported to have a variety of pharmacologic effects, including inhibition of cell cycle progression. Here, we investigated the mechanisms of BBR protection of neuronal cells from cell death induced by the Parkinson’s disease-related neurotoxin 6-hydroxydopamine (6-OHDA). Pretreatment of SH-SY5Y cells with BBR significantly reduced 6-OHDAinduced generation of reactive oxygen species (ROS), caspase-3 activation, and subsequent cell death. BBR also upregulated heme oxygenase-1 (HO-1) expression, which conferred protection against 6-OHDA-induced dopaminergic neuron injury and besides, effect of BBR on HO-1 was reversed by siRNA-Nrf2. Furthermore, BBR induced PI3K/Akt and p38 activation, which are involved in the induction of Nrf2 expression and neuroprotection. These results suggest that BBR may be useful as a therapeutic agent for the treatment of dopaminergic neuronal diseases.
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