We are analyzing https://link.springer.com/article/10.1007/s10059-013-0172-0.

Title:
Induction of mitochondrial dysfunction by poly(ADP-ribose) polymer: Implication for neuronal cell death | Molecules and Cells
Description:
Poly(ADP-ribose) polymerase-1 (PARP-1) mediates neuronal cell death in a variety of pathological conditions involving severe DNA damage. Poly(ADP-ribose) (PAR) polymer is a product synthesized by PARP-1. Previous studies suggest that PAR polymer heralds mitochondrial apoptosis-inducing factor (AIF) release and thereby, signals neuronal cell death. However, the details of the effects of PAR polymer on mitochondria remain to be elucidated. Here we report the effects of PAR polymer on mitochondria in cells in situ and isolated brain mitochondria in vitro. We found that PAR polymer causes depolarization of mitochondrial membrane potential and opening of the mitochondrial permeability transition pore early after injury. Furthermore, PAR polymer specifically induces AIF release, but not cytochrome c from isolated brain mitochondria. These data suggest PAR polymer as an endogenous mitochondrial toxin and will further our understanding of the PARP-1-dependent neuronal cell death paradigm.
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Topics {✒️}

month download article/chapter seong-woon yu apoptosis-inducing factor substitutes eun-kyoung kim peripheral-type benzodiazepine receptor polymer-induced cell death cells seung-hoon baek polymerase-1-dependent cell death mitochondrial permeability transition apoptosis-inducing factor apoptosis inducing factor neuronal cell death dna damage signaling full article pdf privacy choices/manage cookies quantitative fluorescent indicator mitochondrial membrane potentials endogenous mitochondrial toxin apoptotic cell death conditions privacy policy related subjects mitochondrial membrane potential outer membrane permeabilization previous studies suggest european economic area ischemic rat hepatocytes cellular stress signaling article baek article molecules flow cytometric analysis accepting optional cookies j-aggregate formation daegu gyeongbuk institute isolated brain mitochondria rat brain mitochondria main content log authors correspondence journal finder publish article log cell death cell death 2009 article cite polymer access mitochondrial dysfunction par polymer personal data ca2+-overload enhanced apoptosis induces cleavage privacy policy

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         description:Poly(ADP-ribose) polymerase-1 (PARP-1) mediates neuronal cell death in a variety of pathological conditions involving severe DNA damage. Poly(ADP-ribose) (PAR) polymer is a product synthesized by PARP-1. Previous studies suggest that PAR polymer heralds mitochondrial apoptosis-inducing factor (AIF) release and thereby, signals neuronal cell death. However, the details of the effects of PAR polymer on mitochondria remain to be elucidated. Here we report the effects of PAR polymer on mitochondria in cells in situ and isolated brain mitochondria in vitro. We found that PAR polymer causes depolarization of mitochondrial membrane potential and opening of the mitochondrial permeability transition pore early after injury. Furthermore, PAR polymer specifically induces AIF release, but not cytochrome c from isolated brain mitochondria. These data suggest PAR polymer as an endogenous mitochondrial toxin and will further our understanding of the PARP-1-dependent neuronal cell death paradigm.
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