We are analyzing https://link.springer.com/article/10.1007/s10014-010-0007-z.

Title:
Angiogenesis and invasion in glioma | Brain Tumor Pathology
Description:
Despite advances in surgical and medical therapy, glioblastoma consistently remains a fatal disease. Over the last 20 years, no significant increase in survival has been achieved for patients with this disease. The formation of abnormal tumor vasculature and glioma cell invasion along white matter tracts are believed to be the major factors responsible for the resistance of these tumors to treatment. Therefore, investigation of angiogenesis and invasion in glioblastoma is essential for the development of a curative therapy. In our report, we first reviewed certain histopathological studies that focus on angiogenesis and invasion of human malignant gliomas. Second, we considered several animal models of glioma available for studying angiogenesis and invasion, including our novel animal models. Third, we focused on the molecular aspects of glioma angiogenesis and invasion, and the key mediators of these processes. Finally, we discussed the recent and ongoing clinical trials targeting tumor angiogenesis and invasion in glioma patients. A better understanding of the mechanism of glioma angiogenesis and invasion will lead to the development of new treatment methods.
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Keywords {🔍}

google, scholar, pubmed, article, cas, angiogenesis, cancer, invasion, glioma, cell, gliomas, brain, tumor, glioblastoma, res, malignant, clin, growth, cells, migration, human, exp, expression, tumors, sci, patients, vascular, biol, endothelial, phase, therapy, molecular, oncol, integrin, access, neurol, neurooncol, multiforme, study, zagzag, factor, recurrent, inhibitor, privacy, cookies, content, hypoxia, metastasis, int, neurosci,

Topics {✒️}

kazuhiko kurozumi & isao date targets raf/mek/erk pathway month download article/chapter central cell-binding domain transforming growth factor-beta induce c-met expression hypoxia-inducible factor 1alpha rabbit brain-tumor model tyrosine kinases vegfr/pdgfr activating invasion-enhancing genes molecularly targeted therapy anti-angiogenic glioma therapy thalidomide-induced limb teratogenesis pdgf-b-deficient mice mammalian oxygen-sensing pathway vascular endothelial cells hypoxia-inducible factor 1 synthetic matrix-metalloproteinase inhibitors links vascular pathology recurrent high-grade gliomas full article pdf related subjects vascular integrin alpha anti-angiogenic therapy sense p16 genes cd44s-targeted treatment msap enhances migration integrin-mediated signaling adenovirus-mediated transfer privacy choices/manage cookies glioma cell migration cancer cell lines focal adhesion kinase nervous system endothelial junctional proteins nf-kappab pathway reardon da jain rk manning tj jr adult brain tumor carcinoma cell spreading apoptotic cell death vascular apoptosis glioma cell invasion glioblastoma cell proliferation desferrioxamine-induced invasion specific downstream effector protein kinase blood-vessel formation glioblastoma consistently remains

Questions {❓}

Dermietzel R, Spray DC (1993) Gap junctions in the brain: where, what type, how many and why?

Schema {🗺️}

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