We are analyzing https://link.springer.com/article/10.1007/s00792-012-0506-4.

Title:
Deinococcus radiodurans YgjD and YeaZ are involved in the repair of DNA cross-links | Extremophiles
Description:
Orthologs of Escherichia coli ygjD and yeaZ genes are highly conserved in various organisms. The genome of the radioresistant bacterium Deinococcus radiodurans possesses single orthologs of ygjD (DR_0382) and yeaZ (DR_0756). Complete loss of either one or both genes did not result in any significant changes in cell growth efficiency, indicating that both genes are not essential for cell viability in D. radiodurans, unlike the case with other species such as E. coli, Bacillus subtilis and Saccharomyces cerevisiae. Survival rates following DNA damage induced by hydrogen peroxide (H2O2), N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), ultra violet (UV) radiation, γ-rays, cisplatin and mitomycin C (MMC) were compared among the wild-type strain and D. radiodurans ygjD/yeaZ null mutants. Cell viability of the null mutants did not decrease following exposure to H2O2 or MNNG. In addition, the reduction in cell viability following exposure to γ-rays, UV radiation or cisplatin was marginal in the null mutants compared to the wild-type strain. Interestingly, the null mutants exhibited high sensitivity to MMC, which mainly causes interstrand DNA cross-links. The sensitivity of the null mutants to MMC was restored to that of the wild type by transformation with plasmids expressing these genes. These results suggest that D. radiodurans ygjD and yeaZ genes are involved in DNA repair and play a role in the repair of DNA cross-links.
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Keywords {🔍}

article, google, scholar, pubmed, cas, radiodurans, deinococcus, dna, repair, essential, yeaz, genes, gene, narumi, ygjd, radiation, mutants, research, satoh, bacteriol, onodera, cell, resistance, universal, privacy, cookies, content, information, conserved, genome, null, identification, proteins, analysis, publish, search, involved, crosslinks, takefumi, coli, radioresistant, bacterium, viability, mitomycin, access, bacterial, uvra, micrococcus, biotechnol, microbiol,

Topics {✒️}

month download article/chapter interstrand dna cross-links dna repair-deficient mutant intrastrand cross-link adduct cancer-testis antigen defines broad-spectrum antibacterial targets katsuya satoh & issay narumi genome-wide screen identifies universal kae1/ygjd protein universal kae1/qri7/ygjd dna damage induced article extremophiles aims full article pdf dna cross-links deinococcus radiodurans ygjd related subjects privacy choices/manage cookies dna repair gene repair dna damaged jsps research fellowship essential bacterial genes radio-resistant micrococcus universal protein kae1 micrococcus radiodurans defective essential protein gcp apurinic-endonuclease activity high salt concentrations article onodera escherichia coli ygjd universal trna nucleoside european economic area double-strand break cyanobacterium synechocystis sp c-terminal domain arrested replication forks uvra2 gene product takefumi onodera universal trna modification salt-sensitive mutants conditions privacy policy de crécy-lagard mitomycin-sensitive strains insertion sequence element essential protein yeaz �-nitro-n-nitrosoguanidine mendez-rios jd toxic glycated proteins deinococcus radiodurans wild-type strain el yacoubi

Questions {❓}

Blasius M, Sommer S, Hübscher U (2008) Deinococcus radiodurans: what belongs to the survival kit?
Galperin MY, Koonin EV (2010) From complete genome sequence to ‘complete’ understanding?

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         description:Orthologs of Escherichia coli ygjD and yeaZ genes are highly conserved in various organisms. The genome of the radioresistant bacterium Deinococcus radiodurans possesses single orthologs of ygjD (DR_0382) and yeaZ (DR_0756). Complete loss of either one or both genes did not result in any significant changes in cell growth efficiency, indicating that both genes are not essential for cell viability in D. radiodurans, unlike the case with other species such as E. coli, Bacillus subtilis and Saccharomyces cerevisiae. Survival rates following DNA damage induced by hydrogen peroxide (H2O2), N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), ultra violet (UV) radiation, γ-rays, cisplatin and mitomycin C (MMC) were compared among the wild-type strain and D. radiodurans ygjD/yeaZ null mutants. Cell viability of the null mutants did not decrease following exposure to H2O2 or MNNG. In addition, the reduction in cell viability following exposure to γ-rays, UV radiation or cisplatin was marginal in the null mutants compared to the wild-type strain. Interestingly, the null mutants exhibited high sensitivity to MMC, which mainly causes interstrand DNA cross-links. The sensitivity of the null mutants to MMC was restored to that of the wild type by transformation with plasmids expressing these genes. These results suggest that D. radiodurans ygjD and yeaZ genes are involved in DNA repair and play a role in the repair of DNA cross-links.
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      description:Orthologs of Escherichia coli ygjD and yeaZ genes are highly conserved in various organisms. The genome of the radioresistant bacterium Deinococcus radiodurans possesses single orthologs of ygjD (DR_0382) and yeaZ (DR_0756). Complete loss of either one or both genes did not result in any significant changes in cell growth efficiency, indicating that both genes are not essential for cell viability in D. radiodurans, unlike the case with other species such as E. coli, Bacillus subtilis and Saccharomyces cerevisiae. Survival rates following DNA damage induced by hydrogen peroxide (H2O2), N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), ultra violet (UV) radiation, γ-rays, cisplatin and mitomycin C (MMC) were compared among the wild-type strain and D. radiodurans ygjD/yeaZ null mutants. Cell viability of the null mutants did not decrease following exposure to H2O2 or MNNG. In addition, the reduction in cell viability following exposure to γ-rays, UV radiation or cisplatin was marginal in the null mutants compared to the wild-type strain. Interestingly, the null mutants exhibited high sensitivity to MMC, which mainly causes interstrand DNA cross-links. The sensitivity of the null mutants to MMC was restored to that of the wild type by transformation with plasmids expressing these genes. These results suggest that D. radiodurans ygjD and yeaZ genes are involved in DNA repair and play a role in the repair of DNA cross-links.
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