We are analyzing https://link.springer.com/article/10.1007/s00774-023-01493-0.

Title:
Bone–fat linkage via interleukin-11 in response to mechanical loading | Journal of Bone and Mineral Metabolism
Description:
Positive regulators of bone formation, such as mechanical loading and PTH, stimulate and negative regulators, such as aging and glucocorticoid excess, suppress IL-11 gene transcription in osteoblastic cells. Signal transduction from mechanical loading and PTH stimulation involves two pathways: one is Ca2+–ERK–CREB pathway which facilitates binding of ∆FosB/JunD to the AP-1 site to enhance IL-11 gene transcription, and the other is Smad1/5 phosphorylation that promotes IL-11 gene transcription via SBE binding and complex formation with ∆FosB/JunD. The increased IL-11 suppresses Sost expression via IL-11Rα–STAT1/3–HDAC4/5 pathway and enhances Wnt signaling in the bone to stimulate bone formation. Thus, IL-11 mediates stimulatory and inhibitory signals of bone formation by affecting Wnt signaling. Physiologically important stimulation of bone formation is exercise-induced mechanical loading, but exercise simultaneously requires energy source for muscle contraction. Exercise-induced stimulation of IL-11 expression in the bone increases the secretion of IL-11 from the bone. The increased circulating IL-11 acts like a hormone to enhance adipolysis as an energy source with a reduction in adipogenic differentiation via a suppression of Dkk1/2 expression in the adipose tissue. Such bone–fat linkage can be a mechanism whereby exercise increases bone mass and, at the same time, maintains energy supply from the adipose tissue.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, bone, google, scholar, cas, matsumoto, formation, interleukin, central, signaling, mechanical, hiasa, masahiro, endo, access, gene, expression, fukumoto, rev, inoue, nat, privacy, cookies, content, journal, research, loading, transcription, pathway, wnt, exercise, differentiation, kido, factor, commun, miner, res, cytokine, information, publish, search, metabolism, stimulate, glucocorticoid, adipogenesis, open, mice, ito, receptor,

Topics {✒️}

wnt3a/β-catenin signalling pathway il-11rα–stat1/3–hdac4/5 pathway month download article/chapter extracellular-signal regulated kinase spaceflight-induced bone loss exercise-induced mechanical loading ca2+–erk–creb pathway fgf23-related hypophosphatemic diseases nishiyama dental academy exercise-induced stimulation full article pdf mineral metabolism aims bone–fat linkage stimulate osteoblast differentiation privacy choices/manage cookies related subjects stimulate bone formation stimulating osteoblast differentiation attenuating osteoblast differentiation enhances wnt signaling affecting wnt signaling impaired bone formation increases bone formation deltafosb transcription factor il11ra1 knockout mice renal stone formation systemic adipogenesis cortical bone mass interleukin-11 receptor signaling enhance adipolysis maintains energy supply check access instant access article journal bmp receptor signaling signaling cross-talk european economic area physiologically important stimulation x-linked hypophosphatemia unliganded fgf receptor lung fibro-inflammation 90-day bed rest restore normal gain fosb/∆fosb gene article hiasa article log conditions privacy policy sims na il-11 mediates stimulatory decreased ap-1 activity

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Bone–fat linkage via interleukin-11 in response to mechanical loading
         description:Positive regulators of bone formation, such as mechanical loading and PTH, stimulate and negative regulators, such as aging and glucocorticoid excess, suppress IL-11 gene transcription in osteoblastic cells. Signal transduction from mechanical loading and PTH stimulation involves two pathways: one is Ca2+–ERK–CREB pathway which facilitates binding of ∆FosB/JunD to the AP-1 site to enhance IL-11 gene transcription, and the other is Smad1/5 phosphorylation that promotes IL-11 gene transcription via SBE binding and complex formation with ∆FosB/JunD. The increased IL-11 suppresses Sost expression via IL-11Rα–STAT1/3–HDAC4/5 pathway and enhances Wnt signaling in the bone to stimulate bone formation. Thus, IL-11 mediates stimulatory and inhibitory signals of bone formation by affecting Wnt signaling. Physiologically important stimulation of bone formation is exercise-induced mechanical loading, but exercise simultaneously requires energy source for muscle contraction. Exercise-induced stimulation of IL-11 expression in the bone increases the secretion of IL-11 from the bone. The increased circulating IL-11 acts like a hormone to enhance adipolysis as an energy source with a reduction in adipogenic differentiation via a suppression of Dkk1/2 expression in the adipose tissue. Such bone–fat linkage can be a mechanism whereby exercise increases bone mass and, at the same time, maintains energy supply from the adipose tissue.
         datePublished:2024-02-07T00:00:00Z
         dateModified:2024-02-07T00:00:00Z
         pageStart:447
         pageEnd:454
         sameAs:https://doi.org/10.1007/s00774-023-01493-0
         keywords:
            Wnt signal
            Sclerostin
            Exercise
            Bone formation
            Adipolysis
            Metabolic Diseases
            Orthopedics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig4_HTML.png
         isPartOf:
            name:Journal of Bone and Mineral Metabolism
            issn:
               1435-5604
               0914-8779
            volumeNumber:42
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Nature Singapore
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Masahiro Hiasa
               url:http://orcid.org/0000-0002-4830-6274
               affiliation:
                     name:Tokushima University Graduate School of Dentistry
                     address:
                        name:Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Dentistry, Tokushima, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Itsuro Endo
               affiliation:
                     name:Tokushima University Graduate School of Medical Sciences
                     address:
                        name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Toshio Matsumoto
               url:http://orcid.org/0000-0001-6174-2591
               affiliation:
                     name:Tokushima University Graduate School of Medical Sciences
                     address:
                        name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Bone–fat linkage via interleukin-11 in response to mechanical loading
      description:Positive regulators of bone formation, such as mechanical loading and PTH, stimulate and negative regulators, such as aging and glucocorticoid excess, suppress IL-11 gene transcription in osteoblastic cells. Signal transduction from mechanical loading and PTH stimulation involves two pathways: one is Ca2+–ERK–CREB pathway which facilitates binding of ∆FosB/JunD to the AP-1 site to enhance IL-11 gene transcription, and the other is Smad1/5 phosphorylation that promotes IL-11 gene transcription via SBE binding and complex formation with ∆FosB/JunD. The increased IL-11 suppresses Sost expression via IL-11Rα–STAT1/3–HDAC4/5 pathway and enhances Wnt signaling in the bone to stimulate bone formation. Thus, IL-11 mediates stimulatory and inhibitory signals of bone formation by affecting Wnt signaling. Physiologically important stimulation of bone formation is exercise-induced mechanical loading, but exercise simultaneously requires energy source for muscle contraction. Exercise-induced stimulation of IL-11 expression in the bone increases the secretion of IL-11 from the bone. The increased circulating IL-11 acts like a hormone to enhance adipolysis as an energy source with a reduction in adipogenic differentiation via a suppression of Dkk1/2 expression in the adipose tissue. Such bone–fat linkage can be a mechanism whereby exercise increases bone mass and, at the same time, maintains energy supply from the adipose tissue.
      datePublished:2024-02-07T00:00:00Z
      dateModified:2024-02-07T00:00:00Z
      pageStart:447
      pageEnd:454
      sameAs:https://doi.org/10.1007/s00774-023-01493-0
      keywords:
         Wnt signal
         Sclerostin
         Exercise
         Bone formation
         Adipolysis
         Metabolic Diseases
         Orthopedics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00774-023-01493-0/MediaObjects/774_2023_1493_Fig4_HTML.png
      isPartOf:
         name:Journal of Bone and Mineral Metabolism
         issn:
            1435-5604
            0914-8779
         volumeNumber:42
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Nature Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Masahiro Hiasa
            url:http://orcid.org/0000-0002-4830-6274
            affiliation:
                  name:Tokushima University Graduate School of Dentistry
                  address:
                     name:Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Dentistry, Tokushima, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Itsuro Endo
            affiliation:
                  name:Tokushima University Graduate School of Medical Sciences
                  address:
                     name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Toshio Matsumoto
            url:http://orcid.org/0000-0001-6174-2591
            affiliation:
                  name:Tokushima University Graduate School of Medical Sciences
                  address:
                     name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Bone and Mineral Metabolism
      issn:
         1435-5604
         0914-8779
      volumeNumber:42
Organization:
      name:Springer Nature Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Tokushima University Graduate School of Dentistry
      address:
         name:Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Dentistry, Tokushima, Japan
         type:PostalAddress
      name:Tokushima University Graduate School of Medical Sciences
      address:
         name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
         type:PostalAddress
      name:Tokushima University Graduate School of Medical Sciences
      address:
         name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Masahiro Hiasa
      url:http://orcid.org/0000-0002-4830-6274
      affiliation:
            name:Tokushima University Graduate School of Dentistry
            address:
               name:Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Dentistry, Tokushima, Japan
               type:PostalAddress
            type:Organization
      name:Itsuro Endo
      affiliation:
            name:Tokushima University Graduate School of Medical Sciences
            address:
               name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
               type:PostalAddress
            type:Organization
      name:Toshio Matsumoto
      url:http://orcid.org/0000-0001-6174-2591
      affiliation:
            name:Tokushima University Graduate School of Medical Sciences
            address:
               name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Dentistry, Tokushima, Japan
      name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
      name:Department of Endocrinology, Metabolism and Hematology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(144)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.09s.

LINK . SPRINGER . COM {}