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Title:
Taurine increases mitochondrial buffering of calcium: role in neuroprotection | Amino Acids
Description:
We have determined the role of mitochondria in the sequestration of calcium after stimulation of cerebellar granule cells with glutamate. In addition we have evaluated the neuroprotective role of taurine in excitotoxic cell death. Mitochondrial inhibitors were used to determine the calcium buffering capacity of mitochondria, as well as how taurine regulates the ability of mitochondria to buffer intracellular calcium during glutamate depolarization and excitotoxicity. We report here that pre-treatment of cerebellar granule cells with taurine (1 mM, 24 h) significantly counteracted glutamate excitotoxicity. The neuroprotective role of taurine was mediated through regulation of cytoplasmic free calcium ([Ca2+] i ), and intra-mitochondrial calcium homeostasis, as determined by fluo-3 and 45Ca2+-uptake. Furthermore, the overall mitochondrial function was increased in the presence of taurine, as assessed by rhodamine accumulation into mitochondria and total cellular ATP levels. We specifically tested the hypothesis that taurine reduces glutamate excitotoxicity through both the enhancement of mitochondrial function and the regulation of intracellular (cytoplasmic and intra-mitochondrial) calcium homeostasis. The role of taurine in modulating mitochondrial calcium homeostasis could be of particular importance under pathological conditions that are characterized by excessive calcium overloads. Taurine may serve as an endogenous neuroprotective molecule against brain insults.
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google, scholar, article, cas, pubmed, calcium, taurine, mitochondrial, glutamate, neurosci, role, mitochondria, excitotoxicity, cells, cell, homeostasis, neuronal, lett, cerebellar, amino, acids, idrissi, granule, pharmacol, rat, febs, privacy, cookies, content, intracellular, brain, access, neurochem, function, information, publish, search, death, uptake, neurons, related, biol, nicholls, cultured, res, effects, data, log, journal, research,

Topics {✒️}

article google scholar month download article/chapter strychnine-insensitive glycine/nmda sites short-duration glutamate challenge intra-mitochondrial calcium homeostasis cerebellar granule cells taurine-sensitive chloride channels glutamate-induced deregulation full article pdf calcium buffering capacity stabilizing calcium homeostasis stauderman ma varney neuronal calcium recovery induce neuronal death cardiac muscle cells privacy choices/manage cookies excitotoxic cell death carabez rj huxtable programmed cell death acute glutamate excitotoxicity glutamate excitotoxicity studied glutamate-stimulated neurons subsequent neuronal degeneration brustovetsky jm dubinsky sadée jm quillan central nervous system abdeslem el idrissi independent mitochondrial damage dyak28xnt1squ70%3d 10 dyak2cxhvvyrsrs%3d 10 taurine binding sites excessive calcium overloads mediates calcium influx calcium ion uptake buffer intracellular calcium plasma membrane ca2+/ structurally related analogues amino acids 34 mitochondrial membrane potential mitochondria transport calcium cytosolic ca2+ imaging cortical circuit formation neurotoxic glutamate treatment intracellular ca2+ network zajdela hepatoma mitochondrial article log cerebellar cells taurine transport antagonist cytoplasmic free calcium calcium homeostasis

Questions {❓}

B Lucas-Heron B Le Ray N Schmitt (1995) Does calmitine, a protein specific for the mitochondrial matrix of skeletal muscle, play a key role in mitochondrial function?

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