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Keywords {🔍}

article, lithium, ppa, phosphatase, activity, valproate, brain, access, privacy, cookies, content, journal, research, protein, expression, department, biomedical, hiroshima, university, information, publish, search, serinethreonine, rat, cortex, psychiatry, school, sciences, data, log, neural, induces, tsuji, morinobu, tanaka, yamawaki, treatment, administration, open, discover, neurosciences, medical, graduate, springer, optional, analysis, personal, parties, policy, find,

Topics {✒️}

serine/threonine phosphatase activity month download article/chapter privacy choices/manage cookies full article pdf protein phosphatase 2a related subjects neural transmission aims rat frontal cortex european economic area scope submit manuscript immunohistochemical analyses demonstrated neuronal functions induced authors' address conditions privacy policy frontier medical science april 2003 volume 110 therapeutic action accepting optional cookies journal finder publish usage analysis accepted october 22 check access instant access article journal frontal cortex lithium administration tended article log cerebral cortex biomedical research article cite 1007/s00702-002-0798-0 keywords article tsuji privacy policy personal data jp rights books a access optional cookies manage preferences gene expression neural transm 110 journal publish subscription content similar content information data protection medical sciences essential cookies cookies skip expression published

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         headline:Lithium, but not valproate, induces the serine/threonine phosphatase activity of protein phosphatase 2A in the rat brain, without affecting its expression
         description: Protein phosphatase 2A (PP2A) regulates protein kinase cascades and thus plays an important role in the regulation of cell growth, gene expression and development. We examined the influence of lithium and valproate on the expression of PP2A and its serine/threonine phosphatase activity in the rat frontal cortex and hippocampus. Western blot and immunohistochemical analyses demonstrated that neither lithium nor valproate treatment had an effect on the levels of PP2A immunoreactivity in these brain regions. However, administration of lithium for 1 or 14 days significantly upregulated the activity of PP2A in the frontal cortex. Similarly, lithium administration tended to increase the activity of PP2A in the hippocampus. In contrast, neither a single nor repeated administration of valproate affected the activity of PP2A in these brain regions. These findings indicate that lithium, but not valproate, upregulated the activity of PP2A in the rat brain. It is suggested that the changes in neuronal functions induced by PP2A may be, at least in part, associated with the therapeutic action of lithium.
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            Keywords: Protein phosphatase 2A (PP2A)
            serine/threonine phosphatase activity
            dephosphorylation
            lithium
            valproate.
            Neurology
            Psychiatry
            Neurosciences
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      headline:Lithium, but not valproate, induces the serine/threonine phosphatase activity of protein phosphatase 2A in the rat brain, without affecting its expression
      description: Protein phosphatase 2A (PP2A) regulates protein kinase cascades and thus plays an important role in the regulation of cell growth, gene expression and development. We examined the influence of lithium and valproate on the expression of PP2A and its serine/threonine phosphatase activity in the rat frontal cortex and hippocampus. Western blot and immunohistochemical analyses demonstrated that neither lithium nor valproate treatment had an effect on the levels of PP2A immunoreactivity in these brain regions. However, administration of lithium for 1 or 14 days significantly upregulated the activity of PP2A in the frontal cortex. Similarly, lithium administration tended to increase the activity of PP2A in the hippocampus. In contrast, neither a single nor repeated administration of valproate affected the activity of PP2A in these brain regions. These findings indicate that lithium, but not valproate, upregulated the activity of PP2A in the rat brain. It is suggested that the changes in neuronal functions induced by PP2A may be, at least in part, associated with the therapeutic action of lithium.
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         Neurology
         Psychiatry
         Neurosciences
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