We are analyzing https://link.springer.com/article/10.1007/s00604-022-05411-5.

Title:
Glycosylated phospholipid-coated upconversion nanoparticles for bioimaging of non-muscle invasive bladder cancers | Microchimica Acta
Description:
Detection of non-muscle invasive bladder cancer (NMIBC) is crucial to facilitate complete tumor resection, thus improving the survival rate as well as reducing the recurrence frequency and treatment expense. Fluorescence imaging cystoscopy is an effective method for the detection of NMIBC. However, its application is limited as the commonly applied fluorescent agents such as dyes and photosensitizers usually lack specific tumor accumulation and are vulnerable to photobleaching. Furthermore, the broad emission band of conventional fluorescent agents limits their imaging and detection efficacy. To overcome these limitations, upconversion nanoparticles (UCNPs) have been selected as the fluorescent agent, due to their resistance to photobleaching, less background auto-fluorescence, and narrow emission bands. In order to achieve active tumor targeting, the UCNPs are coated with a glycosylated phospholipid layer. The glycosylated phospholipid-coated UCNPs exhibited high selective accumulation in cancer cells over normal cells and enhanced the upconversion luminescence (UCL) (at 540 nm and 660 nm) from bladder cancer cells under 980 nm laser irradiation. Glycosylated phospholipid coating that promotes uptake of UCNPs by cancer cells, and UCL emitted from UCNPs under NIR (980 nm) laser irradiation for cancer cell imaging.
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Keywords {🔍}

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Topics {✒️}

nir-responsive silica-coated naybf4 lesion-level diagnostic meta-analysis glycosylated phospholipid layer koon gee neoh month download article/chapter muscle-invasive bladder cancer x-ray-activated nanosystems endoscopic molecular imaging fluorescence imaging compared fluorescence imaging cystoscopy er3+ upconversion nanoparticle photon-upconversion nanoparticles full article pdf cancer cell imaging background auto-fluorescence related subjects hexaminolevulinate fluorescence cystoscopy 64-slice ct urography pn high contrast privacy choices/manage cookies bladder cancer cells upconversion fluorescent nanomaterials sneha sree mullapudi witjes ja broad emission band narrow emission bands tunable emission colors plotting graphical abstract switchable upconversion emissions superficial bladder cancer human bladder cancer competitive glucose metabolism yong zhang specific targeting narrow band imaging integrin receptor imaging article sun folic acid full shell coating transitional cell carcinoma acknowledge financial support accepted manuscript version cancer therapeutic implications glucose transporter-1 expression anticancer therapy int targeted multiphoton bioimaging upconversion nanoparticles lymph node staging mater sci eng van de rijn

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