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Keywords {🔍}

pubmed, article, google, scholar, lumbar, disc, spine, cas, herniation, resorption, pain, treatment, patients, central, clinical, study, surgery, phila, systematic, herniated, access, review, sciatica, spontaneous, content, albert, open, trial, low, back, privacy, cookies, journal, research, outcomes, sayari, alexander, dino, samartzis, ldh, acupuncture, antiinflammatory, metaanalysis, med, inflammation, surg, nature, springer, information, publish,

Topics {✒️}

month download article/chapter open-source osirix software chee & dino samartzis cedars-sinai medical center note inflammation-preserving treatment steroidal anti-inflammatory drugs dino samartzis evidence-based clinical guideline full article pdf lumbar disc herniation lumbar decompression surgery magnetic resonance imaging lumbar disc herniations prolonged resorption groups european economic area herniated intervertebral discs lumbar disk herniation international spine research privacy choices/manage cookies patient underwent surgery lumbar disc nomenclature disc herniations sizes year multi-imaging study herniated lumbar disk conventional anti-inflammatory endogenous anti-inflammatory related subjects inflammation-preserving treatment clinical outcomes study degenerative lumbar spondylolisthesis moderately degenerative disc post-treatment intervals intervertebral disk lesions ethics declarations conflict additional information publisher' prolonged recovery groups herniated nucleus pulposus affect clinical outcome clinical practice guidelines disc resorption holds exclusive rights check access instant access mr imaging assessment randomized clinical trial randomised controlled trial da costa br gabriel rothman sl combined task forces proresolving lipid mediators

Questions {❓}

• Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM (2016) Resolution of inflammation: what controls its onset?

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         headline:The impact of novel inflammation-preserving treatment towards lumbar disc herniation resorption in symptomatic patients: a prospective, multi-imaging and clinical outcomes study
         description:We performed a prospective one-year multi-imaging study to assess the clinical outcomes and rate of disc resorption in acute lumbar disc herniation (LDH) patients undergoing inflammation-preserving treatment (i.e. no NSAIDS, steroids). All patients received gabapentin to relieve leg pain, 12 sessions of acupuncture. Repeat MRI was performed, every 3 months, after 12 sessions of treatment continued for those without 40% reduction in herniated disc sagittal area. Disc herniations sizes were measured on sagittal T2W MRI sequences, pre-treatment and at post-treatment intervals. Patients were stratified to fast, medium, slow, and prolonged recovery groups in relation to symptom resolution and disc resorption. Ninety patients (51% females; mean age: 48.6 years) were assessed. Mean size of disc herniation was 119.54 ± 54.34 mm2, and the mean VAS-Leg score was 6.12 ± 1.13 at initial presentation. A total of 19 patients (21.1%) improved at the time of the repeat MRI (i.e. within first 3 months post-treatment). 100% of all patient had LDH resorption within one year (mean: 4.4. months). There was no significant difference at baseline LDH between fast, medium, slow, and prolonged resorption groups. Initial LDH size was weakly associated with degree of leg pain at baseline and initial gabapentin levels. Surgery was avoided in all cases. This is the first study to note inflammation-preserving treatment, without conventional anti-inflammatory and steroid medications, as safe and effective for patients with an acute LDH. Rate of disc resorption (100%) was higher than comparative recent meta-analysis findings (66.7%) and no patient underwent surgery.
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      description:We performed a prospective one-year multi-imaging study to assess the clinical outcomes and rate of disc resorption in acute lumbar disc herniation (LDH) patients undergoing inflammation-preserving treatment (i.e. no NSAIDS, steroids). All patients received gabapentin to relieve leg pain, 12 sessions of acupuncture. Repeat MRI was performed, every 3 months, after 12 sessions of treatment continued for those without 40% reduction in herniated disc sagittal area. Disc herniations sizes were measured on sagittal T2W MRI sequences, pre-treatment and at post-treatment intervals. Patients were stratified to fast, medium, slow, and prolonged recovery groups in relation to symptom resolution and disc resorption. Ninety patients (51% females; mean age: 48.6 years) were assessed. Mean size of disc herniation was 119.54 ± 54.34 mm2, and the mean VAS-Leg score was 6.12 ± 1.13 at initial presentation. A total of 19 patients (21.1%) improved at the time of the repeat MRI (i.e. within first 3 months post-treatment). 100% of all patient had LDH resorption within one year (mean: 4.4. months). There was no significant difference at baseline LDH between fast, medium, slow, and prolonged resorption groups. Initial LDH size was weakly associated with degree of leg pain at baseline and initial gabapentin levels. Surgery was avoided in all cases. This is the first study to note inflammation-preserving treatment, without conventional anti-inflammatory and steroid medications, as safe and effective for patients with an acute LDH. Rate of disc resorption (100%) was higher than comparative recent meta-analysis findings (66.7%) and no patient underwent surgery.
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      name:Department of Orthopedic Surgery, Rush University Medical Center, Chicago, USA
      name:The International Spine Research and Innovation Initiative, Rush University Medical Center, Chicago, USA
      name:Department of Orthopedic Surgery, Rush University Medical Center, Chicago, USA
      name:The International Spine Research and Innovation Initiative, Rush University Medical Center, Chicago, USA
      name:Department of Orthopedic Surgery, Rush University Medical Center, Chicago, USA
      name:The International Spine Research and Innovation Initiative, Rush University Medical Center, Chicago, USA
      name:Department of Orthopedic Surgery, Rush University Medical Center, Chicago, USA
      name:The International Spine Research and Innovation Initiative, Rush University Medical Center, Chicago, USA
      name:Department of Orthopedic Surgery, Rush University Medical Center, Chicago, USA
      name:The International Spine Research and Innovation Initiative, Rush University Medical Center, Chicago, USA
      name:Department of Orthopedic Surgery, Rush University Medical Center, Chicago, USA
      name:The International Spine Research and Innovation Initiative, Rush University Medical Center, Chicago, USA
      name:Tkachev Clinic, Volgograd, Russia
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