We are analyzing https://link.springer.com/article/10.1007/s00535-017-1375-5.

Title:
Modifiable factors and esophageal cancer: a systematic review of published meta-analyses | Journal of Gastroenterology
Description:
There are marked differences in the etiology of the major histological types of esophageal cancer (EC)—squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids. Cessation of drinking and smoking significantly reduced ESCC risk. For EAC, an increased risk was reported for smoking, body mass index, and red and processed meat consumption, while risk decreased with Helicobacter pylori infection, low/moderate alcohol drinking, physical activity, and consumption of fruit, vegetables, folate, fiber, beta-carotene, and vitamin C. Differences in results between meta-analyses and mechanisms underlying some of the associations found are discussed. This work reinforces the importance of a separate assessment of EC subtypes to allow for a proper evaluation of incidence trends and planning of prevention/control interventions.
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Keywords {🔍}

cancer, article, google, scholar, epub, pubmed, risk, esophageal, metaanalysis, cas, review, systematic, alcohol, consumption, central, int, cell, adenocarcinoma, carcinoma, squamous, oncol, studies, oesophageal, med, drinking, smoking, eur, gastroenterol, esophagus, gastric, epidemiol, cancers, clin, prev, tobacco, nutr, analysis, intake, adenocarcinomas, human, ann, cardia, association, observational, meat, papillomavirus, index, incidence, soc, bmc,

Topics {✒️}

bárbara peleteiro & nuno lunet month download article/chapter cancer-histological-type dependent manner random-effects meta-regression models comprehensive dose-response meta-analysis digestive tract neoplasms squamous cell carcinoma dose-response meta-analysis upper gastrointestinal cancers full article pdf portuguese oncology institute squamous cell carcinomas population-attributable risk estimations privacy choices/manage cookies evidence-based meta-analyses dose-response relationship low/moderate alcohol drinking site-specific cancer risk modifiable risk factors prevention/control interventions digestive tract cancers related subjects article castro central adiposity isrn prev med asia-pacific region alcohol-related conditions published epidemiological studies dig dis sci cancer prev res aliment pharmacol ther bmc publ health european economic area pre-diagnosis behavior areca nut chewing el-serag hb operational competitiveness programme ptdc/sau-epi/122460/2010 ethics declarations conflict cook mb published meta-analyses sex-specific associations cancer prev apjcp international beacon consortium helicobacter pylori infection conditions privacy policy european prospective investigation body mass index body-mass index gastro-oesophageal reflux

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         description:There are marked differences in the etiology of the major histological types of esophageal cancer (EC)—squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids. Cessation of drinking and smoking significantly reduced ESCC risk. For EAC, an increased risk was reported for smoking, body mass index, and red and processed meat consumption, while risk decreased with Helicobacter pylori infection, low/moderate alcohol drinking, physical activity, and consumption of fruit, vegetables, folate, fiber, beta-carotene, and vitamin C. Differences in results between meta-analyses and mechanisms underlying some of the associations found are discussed. This work reinforces the importance of a separate assessment of EC subtypes to allow for a proper evaluation of incidence trends and planning of prevention/control interventions.
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      description:There are marked differences in the etiology of the major histological types of esophageal cancer (EC)—squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids. Cessation of drinking and smoking significantly reduced ESCC risk. For EAC, an increased risk was reported for smoking, body mass index, and red and processed meat consumption, while risk decreased with Helicobacter pylori infection, low/moderate alcohol drinking, physical activity, and consumption of fruit, vegetables, folate, fiber, beta-carotene, and vitamin C. Differences in results between meta-analyses and mechanisms underlying some of the associations found are discussed. This work reinforces the importance of a separate assessment of EC subtypes to allow for a proper evaluation of incidence trends and planning of prevention/control interventions.
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         Risk factors
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         Hepatology
         Abdominal Surgery
         Colorectal Surgery
         Surgical Oncology
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