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Title:
Bisphosphonates for malignancy-related bone disease: current status, future developments | Supportive Care in Cancer
Description:
This review relates to the efficacy and safety of bisphosphonates in metastatic bone disease. It discusses practical recommendations and possible future indications for bisphosphonate therapy. The current aims of bisphosphonates for metastatic bone disease are to prevent skeletal-related events (SREs), reduce bone pain and improve quality of life. Phase III clinical trials of clodronate and pamidronate have established their efficacy against bone complications in patients with breast cancer and multiple myeloma, while randomized trials have shown SRE reductions with zoledronic acid in patients with breast cancer and multiple myeloma, prostate cancer, and lung and other solid tumors. These bisphosphonates also have some effect on metastatic bone pain. Ibandronate is a new aminobisphosphonate, available in more than 40 countries outside of the US as intravenous and oral formulations for the prevention of skeletal events in patients with breast cancer and bone metastases. Phase III studies have shown that both intravenously and orally administered ibandronate have efficacy for the prevention of skeletal events and for the reduction of metastatic bone pain. In addition to efficacy, the long-term tolerability of bisphosphonates in metastatic bone disease influences drug selection. Besides their use in patients with established bone metastases, recent and ongoing research suggests that bisphosphonates also have clinical benefit in the adjuvant setting, and for the treatment of cancer-treatment-induced bone loss. Such interesting new developments may underpin a new era of bisphosphonate use sometime in the near future.
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Keywords {🔍}

cancer, google, scholar, bone, pubmed, article, cas, breast, patients, metastases, oncol, bisphosphonates, metastatic, clin, acid, body, zoledronic, skeletal, treatment, disease, trial, pain, ibandronate, clodronate, pamidronate, randomized, oral, abstract, complications, suppl, intravenous, therapy, prostate, adjuvant, doubleblind, placebocontrolled, phase, longterm, efficacy, safety, clinical, prevention, study, proc, soc, support, care, bisphosphonate, iii, multiple,

Topics {✒️}

month download article/chapter opioid-resistant bone pain cancer-treatment-induced bone loss jean-jacques body shortened infusion time article supportive care malignancy-related bone disease breast-cancer induced osteolysis chemotherapy-induced ovarian failure double-blind controlled trial placebo-controlled multicenter trial prevent skeletal-related events full article pdf placebo-controlled randomized trial biochemical dose-response study double-blind randomised trial adjuvant pamidronate therapy placebo-controlled study privacy choices/manage cookies zoledronic acid compared placebo-controlled studies tumor-induced osteolysis open-label study ongoing research suggests metastatic bone disease rosen ls placebo-controlled trial article body oral ibandronate compared prevent bone loss bone mineral density metastatic breast carcinoma operable breast cancer phase iii studies metastatic bone pain related subjects bisphosphonate therapy zoledronic acid delays skeletal-related events intravenous ibandronate reduces metastatic breast cancer oral ibandronate reduces long-term impact tumor bone diseases bone health issues advanced breast cancer renal cell carcinoma main adverse events support care cancer metastatic urologic cancer

Questions {❓}

Body J, Mancini I (2002) Bisphosphonates for cancer patients: why, how, and when?

Schema {🗺️}

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