We are analyzing https://link.springer.com/article/10.1007/s00441-013-1750-3.

Title:
Osteoblast ontogeny and implications for bone pathology: an overview | Cell and Tissue Research
Description:
Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this review is to provide an update on the nature of bone-forming osteoblastic cells, highlighting recent data on MSC—osteoblast—osteocyte transformation from a molecular perspective and to discuss osteoblast malfunctions in various bone diseases. We present here the consecutive stages occurring in the differentiation of osteoblasts from MSC, the transcription factors involved and the role of miRNAs in the process. Recent data concerning the pathogenic mechanisms underlying the loss of bone mass and architecture caused by malfunctions in the synthetic activity and metabolism of osteoblasts in osteoporosis, osteogenesis imperfecta, osteoarthritis and rheumatoid arthritis are discussed. The newly acquired knowledge of the ontogeny of osteoblasts will assist in unravelling the abnormalities taking place during their differentiation and will facilitate the prevention and/or treatment of bone diseases by therapy directed against altered molecules and mechanisms.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, google, scholar, cas, bone, cells, cell, differentiation, stem, mesenchymal, osteoblast, central, osteoblasts, res, human, biol, stein, tissue, article, role, osteogenesis, biology, transcription, factors, van, expression, runx, rev, regulation, microrna, imperfecta, arthritis, skeletal, factor, zhang, function, osteoporosis, estrogen, mol, receptor, lee, miner, signaling, stromal, med, endocrinol, acad, sci, growth, karsenty,

Topics {✒️}

month download article/chapter mir-196a regulates proliferation mir-125b regulates calcification anti-tnf alpha antibody mesenchymal stromal cells bone-forming osteoblastic cells msc—osteoblast—osteocyte transformation authors gratefully acknowledge human adipose tissue runx/cbfa/aml factors mesenchymal stem cells trance/rankl knockout mice related subjects mesenchymal stem cell pathology “nicolae simionescu” regulating bmp signaling positive feedback loop human primary osteoblasts tissue research aims el baddini ma network connecting runx2 privacy choices/manage cookies modulating wnt signaling adult stem cells postnatal bone development article titorencu mir-26a targeting osteoblast derived component author correspondence smad1 transcription factor full article pdf osteogenesis imperfecta murine mir-29b contribute bone lining cells bone marrow sinusoids bone marrow stroma check access riggs bl transcription factor osterix dose-dependent effects instant access osteoblast ontogeny bone formation owing rowe dw de saint-georges defining mrna targets microrna regulatory mechanism kinase-mediated transcription directly targeting osterix bone tissue engineering

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Osteoblast ontogeny and implications for bone pathology: an overview
         description:Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this review is to provide an update on the nature of bone-forming osteoblastic cells, highlighting recent data on MSC—osteoblast—osteocyte transformation from a molecular perspective and to discuss osteoblast malfunctions in various bone diseases. We present here the consecutive stages occurring in the differentiation of osteoblasts from MSC, the transcription factors involved and the role of miRNAs in the process. Recent data concerning the pathogenic mechanisms underlying the loss of bone mass and architecture caused by malfunctions in the synthetic activity and metabolism of osteoblasts in osteoporosis, osteogenesis imperfecta, osteoarthritis and rheumatoid arthritis are discussed. The newly acquired knowledge of the ontogeny of osteoblasts will assist in unravelling the abnormalities taking place during their differentiation and will facilitate the prevention and/or treatment of bone diseases by therapy directed against altered molecules and mechanisms.
         datePublished:2013-11-29T00:00:00Z
         dateModified:2013-11-29T00:00:00Z
         pageStart:23
         pageEnd:33
         sameAs:https://doi.org/10.1007/s00441-013-1750-3
         keywords:
            Osteoblasts
            Bone
            Osteoblasts ontogeny
            Mesenchymal stem cell
            Bone pathology
            Human Genetics
            Proteomics
            Molecular Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00441-013-1750-3/MediaObjects/441_2013_1750_Fig1_HTML.gif
         isPartOf:
            name:Cell and Tissue Research
            issn:
               1432-0878
               0302-766X
            volumeNumber:355
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Irina Titorencu
               affiliation:
                     name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                     address:
                        name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vasile Pruna
               affiliation:
                     name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                     address:
                        name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Victor V. Jinga
               affiliation:
                     name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                     address:
                        name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maya Simionescu
               affiliation:
                     name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                     address:
                        name:Cellular and Molecular Biology Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Osteoblast ontogeny and implications for bone pathology: an overview
      description:Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this review is to provide an update on the nature of bone-forming osteoblastic cells, highlighting recent data on MSC—osteoblast—osteocyte transformation from a molecular perspective and to discuss osteoblast malfunctions in various bone diseases. We present here the consecutive stages occurring in the differentiation of osteoblasts from MSC, the transcription factors involved and the role of miRNAs in the process. Recent data concerning the pathogenic mechanisms underlying the loss of bone mass and architecture caused by malfunctions in the synthetic activity and metabolism of osteoblasts in osteoporosis, osteogenesis imperfecta, osteoarthritis and rheumatoid arthritis are discussed. The newly acquired knowledge of the ontogeny of osteoblasts will assist in unravelling the abnormalities taking place during their differentiation and will facilitate the prevention and/or treatment of bone diseases by therapy directed against altered molecules and mechanisms.
      datePublished:2013-11-29T00:00:00Z
      dateModified:2013-11-29T00:00:00Z
      pageStart:23
      pageEnd:33
      sameAs:https://doi.org/10.1007/s00441-013-1750-3
      keywords:
         Osteoblasts
         Bone
         Osteoblasts ontogeny
         Mesenchymal stem cell
         Bone pathology
         Human Genetics
         Proteomics
         Molecular Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00441-013-1750-3/MediaObjects/441_2013_1750_Fig1_HTML.gif
      isPartOf:
         name:Cell and Tissue Research
         issn:
            1432-0878
            0302-766X
         volumeNumber:355
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Irina Titorencu
            affiliation:
                  name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                  address:
                     name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vasile Pruna
            affiliation:
                  name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                  address:
                     name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Victor V. Jinga
            affiliation:
                  name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                  address:
                     name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maya Simionescu
            affiliation:
                  name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
                  address:
                     name:Cellular and Molecular Biology Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cell and Tissue Research
      issn:
         1432-0878
         0302-766X
      volumeNumber:355
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
      address:
         name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
         type:PostalAddress
      name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
      address:
         name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
         type:PostalAddress
      name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
      address:
         name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
         type:PostalAddress
      name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
      address:
         name:Cellular and Molecular Biology Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Irina Titorencu
      affiliation:
            name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
            address:
               name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
               type:PostalAddress
            type:Organization
      name:Vasile Pruna
      affiliation:
            name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
            address:
               name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
               type:PostalAddress
            type:Organization
      name:Victor V. Jinga
      affiliation:
            name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
            address:
               name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
               type:PostalAddress
            type:Organization
      name:Maya Simionescu
      affiliation:
            name:Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy
            address:
               name:Cellular and Molecular Biology Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
      name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
      name:Regenerative Medicine Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
      name:Cellular and Molecular Biology Department, Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(275)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.04s.

LINK . SPRINGER . COM {}