We are analyzing https://link.springer.com/article/10.1007/s00441-010-1018-0.

Title:
Pentraxins in innate immunity: lessons from PTX3 | Cell and Tissue Research
Description:
The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive immunity. The innate immune system is composed of a cellular arm and a humoral arm. Components of the humoral arm include members of the complement cascade and soluble pattern recognition molecules (PRMs). These fluid-phase PRMs represent the functional ancestors of antibodies and play a crucial role in the discrimination between self, non-self and modified-self. Moreover, evidence has been presented that these soluble PRMs participate in the regulation of inflammatory responses and interact with the cellular arm of the innate immune system. Pentraxins consist of a set of multimeric soluble proteins and represent the prototypic components of humoral innate immunity. Based on the primary structure of the protomer, pentraxins are divided into two groups: short pentraxins and long pentraxins. The short pentraxins C-reactive protein and serum amyloid P-component are produced by the liver and represent the main acute phase proteins in human and mouse, respectively. The long pentraxin PTX3 is produced by innate immunity cells (e.g. PMN, macrophages, dendritic cells), interacts with several ligands and plays an essential role in innate immunity, tuning inflammation and matrix deposition. PTX3 provides a paradigm for the mode of action of humoral innate immunity.
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Keywords {🔍}

google, scholar, pubmed, cas, mantovani, pentraxin, ptx, protein, innate, long, creactive, bottazzi, immunol, immunity, garlanda, peri, cells, biol, complement, pentraxins, amyloid, doni, recognition, serum, immune, human, van, humoral, chem, component, activation, regulation, med, article, inflammation, cell, deban, role, jaillon, pattern, acute, exp, introna, expression, plasma, disease, bastone, salvatori, response, research,

Topics {✒️}

month download article/chapter high-sensitivity c-reactive protein aids complement-mediated immunity anti-aspergillus fumigatus efficacy sialic acid-binding lectin tumor necrosis factor-alpha pattern recognition receptors atherogenic lipid profile tnfalpha-induced secreted protein c-reactive protein collaborates ptx3 review published ifn-gamma-inducible protein 10 human c-reactive protein c-reactive protein levels santos cc dos membrane-bound complement inhibitors c-reactive protein binds interferon-gamma inhibits expression humoral innate immunity innate immune system innate immune defense privacy choices/manage cookies tumor necrosis factor livija deban interleukin-1-inducible genes innate immunity cells integrated view serum amyloid p-component dos santos jl tissue research aims related subjects c-reactive protein fluid-phase prms represent late apoptotic neutrophils prevents antinuclear autoimmunity full article pdf boost immune response component prevents proteolysis mammalian scavenger receptors ischemic vascular disease alveolar epithelial cells anti-ptx3 autoantibodies persisting high levels fcgamma receptor ii acute myocardial infarction pathway activation cellular innate immunity elevated maternal levels european research council complement dependent amplification

Questions {❓}

Gillmore JD, Hutchinson WL, Herbert J, Bybee A, Mitchell DA, Hasserjian RP, Yamamura K, Suzuki M, Sabin CA, Pepys MB (2004) Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?
Miyaki A, Maeda S, Yoshizawa M, Misono M, Sasai H, Shimojo N, Tanaka K, Ajisaka R (2010) Is pentraxin 3 involved in obesity-induced decrease in arterial distensibility?

Schema {🗺️}

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         description:The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive immunity. The innate immune system is composed of a cellular arm and a humoral arm. Components of the humoral arm include members of the complement cascade and soluble pattern recognition molecules (PRMs). These fluid-phase PRMs represent the functional ancestors of antibodies and play a crucial role in the discrimination between self, non-self and modified-self. Moreover, evidence has been presented that these soluble PRMs participate in the regulation of inflammatory responses and interact with the cellular arm of the innate immune system. Pentraxins consist of a set of multimeric soluble proteins and represent the prototypic components of humoral innate immunity. Based on the primary structure of the protomer, pentraxins are divided into two groups: short pentraxins and long pentraxins. The short pentraxins C-reactive protein and serum amyloid P-component are produced by the liver and represent the main acute phase proteins in human and mouse, respectively. The long pentraxin PTX3 is produced by innate immunity cells (e.g. PMN, macrophages, dendritic cells), interacts with several ligands and plays an essential role in innate immunity, tuning inflammation and matrix deposition. PTX3 provides a paradigm for the mode of action of humoral innate immunity.
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