We are analyzing https://link.springer.com/article/10.1007/s00439-016-1683-5.

Title:
The hnRNP family: insights into their role in health and disease | Human Genetics
Description:
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

hnrnp, pubmed, google, scholar, article, cas, hnrnps, central, rna, protein, mrna, splicing, cell, proteins, nuclear, binding, biol, alternative, regulation, domain, gene, rnabinding, translation, mol, cancer, found, heterogeneous, exon, domains, smn, family, role, ribonucleoprotein, expression, rbps, multiple, cellular, involved, mrnas, mutations, human, functional, bind, recognition, disease, fig, transcription, cells, motif, regulates,

Topics {✒️}

ca-rich element-binding micrornas delphine bouhy & vincent timmerman p62-positive/tdp43-negative inclusions c-jun n-terminal kinase amyotrophic lateral sclerosis lópez de silanes double-stranded rna-binding domain arg-gly-gly amino acids c9orf72 repeat expansion cyclin-dependent kinase inhibitor tgf-β-mediated emt resulted fronto-temporal lobe dementia article download pdf spinal muscular atrophy polypyrimidine tract-binding protein cytosine/thymidine-rich element single-stranded telomere dna van roon-mom wmc stranded antiparallel β-sheets tgf-beta-mediated phosphorylation c9orf72 als/ftd diseases arg-gly-gly repeats glycine-rich auxiliary domain �-opoid receptor gene c9orf72 repeat expansions human cerebrospinal fluid pre-rrna-binding proteins glycine-rich domain constituting coding rnas context-dependent regulatory mechanism reported post-translational modifications regulates cap-independent translation mrna-destabilizing sequences located c-myc transcription factor g-tract rna sequence telomeric dna-binding activities cell type-restricted activity uv-cross-linking experiments hnrnp a2/b1-mirna complexes develop rna-based therapies multiple rna-binding proteins glycine-rich c-terminus post-transcriptional regulatory roles αcp rna-binding proteins messenger-rna-binding proteins epithelial–mesenchymal transition pathway shared rna-binding properties common rna-binding properties transcript-selective translational induction full size image

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The hnRNP family: insights into their role in health and disease
         description:Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
         datePublished:2016-05-23T00:00:00Z
         dateModified:2016-05-23T00:00:00Z
         pageStart:851
         pageEnd:867
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00439-016-1683-5
         keywords:
            Spinal Muscular Atrophy
            Amyotrophic Lateral Sclerosis Patient
            C9orf72 Repeat Expansion
            Auxiliary Domain
            hnRNP Family
            Human Genetics
            Molecular Medicine
            Gene Function
            Metabolic Diseases
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig5_HTML.gif
         isPartOf:
            name:Human Genetics
            issn:
               1432-1203
               0340-6717
            volumeNumber:135
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Thomas Geuens
               affiliation:
                     name:University of Antwerp-CDE
                     address:
                        name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
                        type:PostalAddress
                     type:Organization
                     name:Institute Born Bunge, University of Antwerp
                     address:
                        name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Delphine Bouhy
               affiliation:
                     name:University of Antwerp-CDE
                     address:
                        name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
                        type:PostalAddress
                     type:Organization
                     name:Institute Born Bunge, University of Antwerp
                     address:
                        name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vincent Timmerman
               affiliation:
                     name:University of Antwerp-CDE
                     address:
                        name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
                        type:PostalAddress
                     type:Organization
                     name:Institute Born Bunge, University of Antwerp
                     address:
                        name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The hnRNP family: insights into their role in health and disease
      description:Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
      datePublished:2016-05-23T00:00:00Z
      dateModified:2016-05-23T00:00:00Z
      pageStart:851
      pageEnd:867
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00439-016-1683-5
      keywords:
         Spinal Muscular Atrophy
         Amyotrophic Lateral Sclerosis Patient
         C9orf72 Repeat Expansion
         Auxiliary Domain
         hnRNP Family
         Human Genetics
         Molecular Medicine
         Gene Function
         Metabolic Diseases
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-016-1683-5/MediaObjects/439_2016_1683_Fig5_HTML.gif
      isPartOf:
         name:Human Genetics
         issn:
            1432-1203
            0340-6717
         volumeNumber:135
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Thomas Geuens
            affiliation:
                  name:University of Antwerp-CDE
                  address:
                     name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
                     type:PostalAddress
                  type:Organization
                  name:Institute Born Bunge, University of Antwerp
                  address:
                     name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Delphine Bouhy
            affiliation:
                  name:University of Antwerp-CDE
                  address:
                     name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
                     type:PostalAddress
                  type:Organization
                  name:Institute Born Bunge, University of Antwerp
                  address:
                     name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vincent Timmerman
            affiliation:
                  name:University of Antwerp-CDE
                  address:
                     name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
                     type:PostalAddress
                  type:Organization
                  name:Institute Born Bunge, University of Antwerp
                  address:
                     name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Human Genetics
      issn:
         1432-1203
         0340-6717
      volumeNumber:135
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Antwerp-CDE
      address:
         name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
         type:PostalAddress
      name:Institute Born Bunge, University of Antwerp
      address:
         name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
         type:PostalAddress
      name:University of Antwerp-CDE
      address:
         name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
         type:PostalAddress
      name:Institute Born Bunge, University of Antwerp
      address:
         name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
         type:PostalAddress
      name:University of Antwerp-CDE
      address:
         name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
         type:PostalAddress
      name:Institute Born Bunge, University of Antwerp
      address:
         name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Thomas Geuens
      affiliation:
            name:University of Antwerp-CDE
            address:
               name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
               type:PostalAddress
            type:Organization
            name:Institute Born Bunge, University of Antwerp
            address:
               name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
               type:PostalAddress
            type:Organization
      name:Delphine Bouhy
      affiliation:
            name:University of Antwerp-CDE
            address:
               name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
               type:PostalAddress
            type:Organization
            name:Institute Born Bunge, University of Antwerp
            address:
               name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
               type:PostalAddress
            type:Organization
      name:Vincent Timmerman
      affiliation:
            name:University of Antwerp-CDE
            address:
               name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
               type:PostalAddress
            type:Organization
            name:Institute Born Bunge, University of Antwerp
            address:
               name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
      name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
      name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
      name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
      name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
      name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium

External Links {🔗}(602)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Particles.js
Prism.js

CDN Services {📦}

Crossref

5.3s.

LINK . SPRINGER . COM {}