We are analyzing https://link.springer.com/article/10.1007/s00439-011-1011-z.

Title:
Genes that escape from X inactivation | Human Genetics
Description:
To achieve a balanced gene expression dosage between males (XY) and females (XX), mammals have evolved a compensatory mechanism to randomly inactivate one of the female X chromosomes. Despite this chromosome-wide silencing, a number of genes escape X inactivation: in women about 15% of X-linked genes are bi-allelically expressed and in mice, about 3%. Expression from the inactive X allele varies from a few percent of that from the active allele to near equal expression. While most genes have a stable inactivation pattern, a subset of genes exhibit tissue-specific differences in escape from X inactivation. Escape genes appear to be protected from the repressive chromatin modifications associated with X inactivation. Differences in the identity and distribution of escape genes between species and tissues suggest a role for these genes in the evolution of sex differences in specific phenotypes. The higher expression of escape genes in females than in males implies that they may have female-specific roles and may be responsible for some of the phenotypes observed in X aneuploidy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Photography

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

article, google, scholar, pubmed, cas, inactivation, gene, chromosome, genet, genes, expression, escape, human, sex, mouse, cell, histone, brain, res, disteche, xlinked, differences, nature, usa, hum, biol, doi, genome, carrel, inactive, sci, nat, mol, syndrome, regulation, molecular, proc, rev, yang, xist, natl, acad, turner, genetics, mammals, silencing, access, mental, retardation, dev,

Topics {✒️}

x-linked mental retardation month download article/chapter targeted x-linked transgene gender-specific gene expression large-scale population study x-linked gene expression de la torre-ubieta intellectual disability post-mortem human brain full article pdf marshall graves ja x-linked gene polymorphic x-chromosome inactivation initiate x-chromosome inactivation related subjects tissue-specific expression xx–xy differences present x-linked genes female-specific roles privacy choices/manage cookies filippova gn age related reactivation hox gene regulation gonadal sex differentiation sex-specific expression heterogeneous gene expression synaptic neuroprotection conferred pennsylvania state college y-linked genes azfa gene dby human timp1 gene macroh2a1 histone variants histone h4 acetylation reproduction-related genes sexually dimorphic genes kinesin transports rna rna-transporting granule chromosome gene expression brown cj sex-specific differences monozygotic female twins histone demethylases utx graves ja arnold ap female-biased expression repressive chromatin modifications xist rna exhibits lyon repeat hypothesis rajpert-de meyts chow jc

Questions {❓}

Arnold AP, Burgoyne PS (2004) Are XX and XY brain cells intrinsically different?
Arnold AP, Chen X (2009) What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues?
Reisert I, Pilgrim C (1991) Sexual differentiation of monoaminergic neurons–genetic or epigenetic?
Zechner U, Wilda M, Kehrer-Sawatzki H, Vogel W, Fundele R, Hameister H (2001) A high density of X-linked genes for general cognitive ability: a run-away process shaping human evolution?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Genes that escape from X inactivation
         description:To achieve a balanced gene expression dosage between males (XY) and females (XX), mammals have evolved a compensatory mechanism to randomly inactivate one of the female X chromosomes. Despite this chromosome-wide silencing, a number of genes escape X inactivation: in women about 15% of X-linked genes are bi-allelically expressed and in mice, about 3%. Expression from the inactive X allele varies from a few percent of that from the active allele to near equal expression. While most genes have a stable inactivation pattern, a subset of genes exhibit tissue-specific differences in escape from X inactivation. Escape genes appear to be protected from the repressive chromatin modifications associated with X inactivation. Differences in the identity and distribution of escape genes between species and tissues suggest a role for these genes in the evolution of sex differences in specific phenotypes. The higher expression of escape genes in females than in males implies that they may have female-specific roles and may be responsible for some of the phenotypes observed in X aneuploidy.
         datePublished:2011-05-26T00:00:00Z
         dateModified:2011-05-26T00:00:00Z
         pageStart:237
         pageEnd:245
         sameAs:https://doi.org/10.1007/s00439-011-1011-z
         keywords:
            Intellectual Disability
            Turner Syndrome
            Variable Escape
            Escape Gene
            Female Cell Line
            Human Genetics
            Molecular Medicine
            Gene Function
            Metabolic Diseases
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-011-1011-z/MediaObjects/439_2011_1011_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-011-1011-z/MediaObjects/439_2011_1011_Fig2_HTML.gif
         isPartOf:
            name:Human Genetics
            issn:
               1432-1203
               0340-6717
            volumeNumber:130
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Joel B. Berletch
               affiliation:
                     name:University of Washington School of Medicine
                     address:
                        name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fan Yang
               affiliation:
                     name:University of Washington School of Medicine
                     address:
                        name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jun Xu
               affiliation:
                     name:Tufts University Cummings School of Veterinary Medicine
                     address:
                        name:Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Laura Carrel
               affiliation:
                     name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine
                     address:
                        name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, Hershey, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christine M. Disteche
               affiliation:
                     name:University of Washington School of Medicine
                     address:
                        name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
                        type:PostalAddress
                     type:Organization
                     name:University of Washington School of Medicine
                     address:
                        name:Department of Medicine, University of Washington School of Medicine, Seattle, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Genes that escape from X inactivation
      description:To achieve a balanced gene expression dosage between males (XY) and females (XX), mammals have evolved a compensatory mechanism to randomly inactivate one of the female X chromosomes. Despite this chromosome-wide silencing, a number of genes escape X inactivation: in women about 15% of X-linked genes are bi-allelically expressed and in mice, about 3%. Expression from the inactive X allele varies from a few percent of that from the active allele to near equal expression. While most genes have a stable inactivation pattern, a subset of genes exhibit tissue-specific differences in escape from X inactivation. Escape genes appear to be protected from the repressive chromatin modifications associated with X inactivation. Differences in the identity and distribution of escape genes between species and tissues suggest a role for these genes in the evolution of sex differences in specific phenotypes. The higher expression of escape genes in females than in males implies that they may have female-specific roles and may be responsible for some of the phenotypes observed in X aneuploidy.
      datePublished:2011-05-26T00:00:00Z
      dateModified:2011-05-26T00:00:00Z
      pageStart:237
      pageEnd:245
      sameAs:https://doi.org/10.1007/s00439-011-1011-z
      keywords:
         Intellectual Disability
         Turner Syndrome
         Variable Escape
         Escape Gene
         Female Cell Line
         Human Genetics
         Molecular Medicine
         Gene Function
         Metabolic Diseases
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-011-1011-z/MediaObjects/439_2011_1011_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-011-1011-z/MediaObjects/439_2011_1011_Fig2_HTML.gif
      isPartOf:
         name:Human Genetics
         issn:
            1432-1203
            0340-6717
         volumeNumber:130
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Joel B. Berletch
            affiliation:
                  name:University of Washington School of Medicine
                  address:
                     name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fan Yang
            affiliation:
                  name:University of Washington School of Medicine
                  address:
                     name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jun Xu
            affiliation:
                  name:Tufts University Cummings School of Veterinary Medicine
                  address:
                     name:Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Laura Carrel
            affiliation:
                  name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine
                  address:
                     name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, Hershey, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christine M. Disteche
            affiliation:
                  name:University of Washington School of Medicine
                  address:
                     name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Washington School of Medicine
                  address:
                     name:Department of Medicine, University of Washington School of Medicine, Seattle, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Human Genetics
      issn:
         1432-1203
         0340-6717
      volumeNumber:130
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Washington School of Medicine
      address:
         name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
         type:PostalAddress
      name:University of Washington School of Medicine
      address:
         name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
         type:PostalAddress
      name:Tufts University Cummings School of Veterinary Medicine
      address:
         name:Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, USA
         type:PostalAddress
      name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine
      address:
         name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, Hershey, USA
         type:PostalAddress
      name:University of Washington School of Medicine
      address:
         name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
         type:PostalAddress
      name:University of Washington School of Medicine
      address:
         name:Department of Medicine, University of Washington School of Medicine, Seattle, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Joel B. Berletch
      affiliation:
            name:University of Washington School of Medicine
            address:
               name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
               type:PostalAddress
            type:Organization
      name:Fan Yang
      affiliation:
            name:University of Washington School of Medicine
            address:
               name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
               type:PostalAddress
            type:Organization
      name:Jun Xu
      affiliation:
            name:Tufts University Cummings School of Veterinary Medicine
            address:
               name:Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, USA
               type:PostalAddress
            type:Organization
      name:Laura Carrel
      affiliation:
            name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine
            address:
               name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, Hershey, USA
               type:PostalAddress
            type:Organization
      name:Christine M. Disteche
      affiliation:
            name:University of Washington School of Medicine
            address:
               name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
               type:PostalAddress
            type:Organization
            name:University of Washington School of Medicine
            address:
               name:Department of Medicine, University of Washington School of Medicine, Seattle, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
      name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
      name:Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, USA
      name:Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, Hershey, USA
      name:Department of Pathology, University of Washington School of Medicine, Seattle, USA
      name:Department of Medicine, University of Washington School of Medicine, Seattle, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(391)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.43s.

LINK . SPRINGER . COM {}