We are analyzing https://link.springer.com/article/10.1007/s00439-003-0983-8.

Title:
Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population | Human Genetics
Description:
Although polymorphism of the mitochondrial DNA 15497guanine/adenine (Mt15497G→A) leads to the Gly251Ser amino acid replacement on human cytochrome b, it is unknown whether functional alteration of the mitochondrion is induced by the Gly251Ser replacement. To see if an association exists between the Mt15497G→A polymorphism and obesity, we examined differences in body size, body composition, and regional body fat distribution between the two genotypes in middle-aged and elderly Japanese individuals (825 women and 906 men). The Mt15497 genotype was determined with an automated colorimetric allele-specific DNA probe assay system using the polymerase chain reaction (PCR) method. The Mt15497G→A polymorphism was detected in 3.5% (n=60) of all subjects: 2.8% (n=23) among women and 4.1% (n=37) among men. After adjusting for age and smoking, we found that body weight, body mass index, waist and hip circumferences, fat mass, fat-free mass, intra-abdominal fat and triglycerides were significantly greater in women with the A allele compared with the G allele (p=0.001–0.025). For men, waist to hip ratio was significantly greater (p=0.032), and waist circumference, intra-abdominal fat and triglycerides had a trend to be significantly greater (p=0.062–0.087) in subjects with the A allele compared with the G allele. These data suggest that the Mt15497 polymorphism may be associated with obesity-related variables and lipid metabolism.
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Topics {✒️}

month download article/chapter significant sex-specific effect mitochondrial dna 15497guanine/adenine histiocytoid cardiomyopathy low-density lipoprotein cholesterol tissue-type plasminogen activator genotype-dependent effects intra-abdominal fat accumulation waist circumference mt15497 genotype plasminogen activator inhibitor-1 mitochondrial dna 15497g/ mitochondrial dna play visceral fat accumulation privacy choices/manage cookies elderly japanese population full article pdf mitochondrial dna variants elderly japanese individuals human body fat body fat distribution obesity-related variables fat-free mass intra-abdominal fat body mass index european economic area polymerase chain reaction 3rd european congress complex iii deficiency intense nonpharmacological intervention 36–3 gengo morioka-cho 55 nadakayama yokone-cho mitochondrial dna 5178 conditions privacy policy stop-codon mutation tomohiro okura article okura check access instant access serum lipid levels accepting optional cookies plasma triglyceride concentration overweight postmenopausal women association exists author correspondence al mt15497 polymorphism gifu international institute journal finder publish japanese population

Questions {❓}

Gerbitz KD (1992) Does the mitochondrial DNA play a role in the pathogenesis of diabetes?

Schema {🗺️}

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         headline:Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population
         description:Although polymorphism of the mitochondrial DNA 15497guanine/adenine (Mt15497G→A) leads to the Gly251Ser amino acid replacement on human cytochrome b, it is unknown whether functional alteration of the mitochondrion is induced by the Gly251Ser replacement. To see if an association exists between the Mt15497G→A polymorphism and obesity, we examined differences in body size, body composition, and regional body fat distribution between the two genotypes in middle-aged and elderly Japanese individuals (825 women and 906 men). The Mt15497 genotype was determined with an automated colorimetric allele-specific DNA probe assay system using the polymerase chain reaction (PCR) method. The Mt15497G→A polymorphism was detected in 3.5% (n=60) of all subjects: 2.8% (n=23) among women and 4.1% (n=37) among men. After adjusting for age and smoking, we found that body weight, body mass index, waist and hip circumferences, fat mass, fat-free mass, intra-abdominal fat and triglycerides were significantly greater in women with the A allele compared with the G allele (p=0.001–0.025). For men, waist to hip ratio was significantly greater (p=0.032), and waist circumference, intra-abdominal fat and triglycerides had a trend to be significantly greater (p=0.062–0.087) in subjects with the A allele compared with the G allele. These data suggest that the Mt15497 polymorphism may be associated with obesity-related variables and lipid metabolism.
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            Molecular Medicine
            Gene Function
            Metabolic Diseases
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      headline:Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population
      description:Although polymorphism of the mitochondrial DNA 15497guanine/adenine (Mt15497G→A) leads to the Gly251Ser amino acid replacement on human cytochrome b, it is unknown whether functional alteration of the mitochondrion is induced by the Gly251Ser replacement. To see if an association exists between the Mt15497G→A polymorphism and obesity, we examined differences in body size, body composition, and regional body fat distribution between the two genotypes in middle-aged and elderly Japanese individuals (825 women and 906 men). The Mt15497 genotype was determined with an automated colorimetric allele-specific DNA probe assay system using the polymerase chain reaction (PCR) method. The Mt15497G→A polymorphism was detected in 3.5% (n=60) of all subjects: 2.8% (n=23) among women and 4.1% (n=37) among men. After adjusting for age and smoking, we found that body weight, body mass index, waist and hip circumferences, fat mass, fat-free mass, intra-abdominal fat and triglycerides were significantly greater in women with the A allele compared with the G allele (p=0.001–0.025). For men, waist to hip ratio was significantly greater (p=0.032), and waist circumference, intra-abdominal fat and triglycerides had a trend to be significantly greater (p=0.062–0.087) in subjects with the A allele compared with the G allele. These data suggest that the Mt15497 polymorphism may be associated with obesity-related variables and lipid metabolism.
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      dateModified:2003-08-02T00:00:00Z
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      pageEnd:436
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         Waist Circumference
         Anthropometric Variable
         Adrenergic Receptor Gene
         Mt15497 Genotype
         Histiocytoid Cardiomyopathy
         Human Genetics
         Molecular Medicine
         Gene Function
         Metabolic Diseases
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               type:PostalAddress
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      affiliation:
            name:National Institute for Longevity Sciences
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            name:National Institute for Longevity Sciences
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            name:Gifu International Institute of Biotechnology
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               name:Department of Gene Therapy, Gifu International Institute of Biotechnology, Gifu, Japan
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