We are analyzing https://link.springer.com/article/10.1007/s00436-016-4982-9.

Title:
Carbonic anhydrase enzyme as a potential therapeutic target for experimental trichinellosis | Parasitology Research
Description:
Trichinellosis is a globally distributed helminthic infection. There is a considerable interest in developing new anti-helminthic drugs affecting all the developmental stages of Trichinella. Acetazolamide (carbonic anhydrase (CA) inhibitor) involves a novel mechanism of action by inhibiting such an essential enzyme for parasite metabolism. This work aimed to study the effect of acetazolamide against different stages of T. spiralis in experimental animals. Mice were divided into three groups: group I: infected and treated with acetazolamide on day 2 post infection (P.I.), group II: infected and treated with acetazolamide on day 12 P.I., and group III: infected non-treated. From each group, small intestine and muscles were removed for histopathological and immunohistochemical studies. Also, total adult and muscle larval count were estimated. We found that acetazolamide was effective in reduction of both adult and muscle larval counts. When given early, the effect was more pronounced on the adults (62.7 %). However, the efficacy of the drug against muscle larvae was increased when given late (63 %). Improvement of the intestinal histopathological changes was observed in all the treated groups. Degeneration of encysted larvae with minimal pathologic changes of infected skeletal muscle was observed in the treated groups. Expression of matrix metalloproteinase-9 showed a statistically significant decrease in the intestinal and muscle tissues in all treated groups as compared to the control group. In conclusion, the present study revealed that acetazolamide, carbonic anhydrase inhibitor, could be a promising drug against both adults and larvae of T. spiralis.
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Keywords {🔍}

pubmed, article, google, scholar, cas, trichinella, spiralis, carbonic, anhydrase, parasitol, acetazolamide, central, trichinellosis, mice, mmp, med, enzyme, therapeutic, experimental, infection, muscle, matrix, agents, anhydrases, chem, privacy, cookies, content, research, potential, parasite, group, infected, treated, intestinal, access, supuran, model, res, data, publish, search, parasitology, saad, effect, groups, expression, doi, vectors, inhibitors,

Topics {✒️}

3-substituted-phenyl-1h-indole-5-sulfonamides month download article/chapter abd ei-aal aa caenorhabditis elegans cah-4b metal-based pharmaceutical agents nematode alpha-carbonic anhydrase anti-helminthic drugs affecting beta-class carbonic anhydrase carbonic anhydrase enzyme mouse-trichinella spiralis model β-carbonic anhydrase beta-class carbonic anhydrases full article pdf carbonic anhydrase inhibitors de sousa mh privacy choices/manage cookies related subjects el-sabaa aa emerging protein targets carbonic anhydrase inhibitor gamma-carbonic anhydrases η-carbonic anhydrases beta carbonic anhydrases aromatic/heterocyclic sulfonamides matrix metalloproteinases mmp-2 matrix metalloproteinase-9 showed l1 trichinella spiralis trichinella spiralis infections albendazole versus ricobendazole statistically significant decrease blunt multiple injuries olmesartan decreased levels cell injury caused el-arousy mh hunting practices increase progesterone receptor determination excretory-secretory glycoproteins excretory-secretory antigens leishmania donovani chagasi database issue trichinella pseudospiralis infections conditions privacy policy anti-parasitic agents carbonic anhydrase intestinal mucositis model protozoan parasite responsible european economic area muscle larval count muscle larval counts dual therapeutic target

Questions {❓}

Bruschi F, Chiumiento L (2011) Trichinella inflammatory myopathy: host or parasite strategy?
Capasso C, Supuran CT (2015) An overview of the alpha-, beta- and gamma-carbonic anhydrases from bacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?
Despommier DD (1998) How does Trichinella spiralis make itself at home?

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