We are analyzing https://link.springer.com/article/10.1007/s00432-022-03918-1.

Title:
Therapeutic approach for digestive system cancers and potential implications of exercise under hypoxia condition: what little is known? a narrative review | Journal of Cancer Research and Clinical Oncology
Description:
Background Cancer, like other chronic pathologies, is associated with the presence of hypoxic regions due to the uncontrolled cell growth. Under this pathological hypoxic condition, various molecular signaling pathways are activated to ensure cell survival, such as those that govern angiogenesis, erythropoiesis, among others. These molecular processes are very similar to the physiological response caused by exposure to altitude (natural hypobaric systemic hypoxia), the use of artificial hypoxia devices (systemic normobaric simulated hypoxia) or the delivery of vascular occlusion to the extremities (also called local hypoxia by the blood flow restriction technique). “Tumor hypoxia” has gained further clinical importance due to its crucial role in both tumor progression and resistance to treatment. However, the ability to manipulate this pathway through physical exercise and systemic hypoxia-mediated signaling pathways could offer an important range of therapeutic opportunities that should be further investigated. Methods This review is focused on the potential implications of systemic hypoxia combined with exercise in digestive system neoplasms prognosis. Articles included in the review were retrieved by searching among the three main scientific databases: PubMed, Scopus, and Embase. Findings The findings of this review suggest that exercise performed under systemic hypoxic conditions could have a positive impact in prognosis and quality of life of the population with digestive system cancers. Conclusions Further studies are needed to consider this paradigm as a new potential intervention in digestive oncological population.
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Keywords {🔍}

pubmed, google, scholar, cancer, cas, central, hypoxia, exercise, cell, physiol, med, tumor, factor, training, review, growth, front, sci, angiogenesis, vascular, role, therapy, biol, article, hypoxic, cells, rev, hypoxiainducible, kim, digestive, responses, int, therapeutic, cancers, physical, hif, oncol, endothelial, res, lee, colorectal, exp, sports, wang, clinical, system, altitude, resistance, colon, immunol,

Topics {✒️}

systems biology view high-affinity pdgf-vegfr interactions author information authors hypoxia-inducible factor-1α enhanced high-intensity interval training hif-1α-mediated metabolic adaption author correspondence josefa león high-intensity exercise/training hypertrophy-oriented resistance training month download article/chapter understanding nano-bio interactions hypoxia-inducible factor-1α endothelium-derived hyperpolarizing factor α-ketoglutarate-dependent dioxygenases hypoxia-regulated gene network digestive system cancers transcriptional coactivator pgc-1α hif1a employs cdk8-mediator amp-activated protein kinase targeting hypoxia-inducible factor-1 aerobic exercise leisure-time physical activity digestive system exercise-oncology research developing small-molecule inhibitors suppresses colon tumorigenesis hypoxia-inducible factor-1 hypoxia-inducible factor 1 hypobaric hypoxic training clinical oncology aims exercise-induced angiogenesis pérez lm springer international publishing hypobaric hypoxia induces/ blood vessel growth �structure–activity relationship” perspective colon cancer survivors systemic hypoxic conditions acute normobaric hypoxia altitude/hypoxic training resistance-relevant mirnas anti-angiogenic therapy immune system sports med-open 3 check access instant access privacy choices/manage cookies uncontrolled cell growth resistance training

Questions {❓}

Burtscher J, Millet GP, Renner-Sattler K, Klimont J, Hackl M, Burtscher M (2021) Moderate altitude residence reduces male colorectal and female breast cancer mortality more than incidence: therapeutic implications?
Girard O, Malatesta D, Millet GP (2017) Walking in hypoxia: an efficient treatment to lessen mechanical constraints and improve health in obese individuals?
Loboda A, Jozkowicz A, Dulak J (2012) HIF-1 versus HIF-2—is one more important than the other?
Serebrovskaya TV, Manukhina EB, Smith ML, Downey HF, Mallet RT (2008) Intermittent hypoxia: cause of or therapy for systemic hypertension?
Therapeutic approach for digestive system cancers and potential implications of exercise under hypoxia condition: what little is known?
Therapeutic approach for digestive system cancers and potential implications of exercise under hypoxia condition: what little is known?

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