We are analyzing https://link.springer.com/article/10.1007/s00432-021-03905-y.

Title:
Predictive values of mutational variant allele frequency in overall survival and leukemic progression of myelodysplastic syndromes | Journal of Cancer Research and Clinical Oncology
Description:
Background The implication of mutational variant allelic frequency (VAF) has been increasingly considered in the prognostic interpretation of molecular data in myeloid malignancies. However, the impact of VAF on outcomes of myelodysplastic syndromes (MDS) has not been extensively explored. Methods Targeted next-generation sequencing was performed in 350 newly diagnosed MDS cases. The associations of mutational VAF of each gene with overall survival (OS) and leukemia-free survival (LFS) were examined by multivariate Cox regression after univariate analysis. Results Shorter OS was independently associated with DNMT3A VAF (HR 1.020 per 1% VAF increase; 95% CI 1.005–1.035; p = 0.011) and TP53 VAF (HR 1.014 per 1% VAF increase; 95% CI 1.006–1.022; p = 0.001). LFS analyses revealed that TET2 VAF (HR 1.013 per 1% VAF increase; 95% CI 1.005–1.022; p = 0.003) and TP53 VAF (HR 1.012 per 1% VAF increase; 95% CI 1.004–1.021; p = 0.005) were independently associated with faster leukemic transformation. Furthermore, we established nomograms to predict OS and LFS, respectively, by integrating independent mutational predictors into the revised International Prognostic Scoring System. Conclusion Our study highlights that VAF of certain genes should be incorporated into routine clinical prognostication of survival and leukemic transformation of MDS.
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article, pubmed, myelodysplastic, google, scholar, syndromes, cas, vaf, patients, frequency, leukemia, data, variant, mutation, prognosis, central, cancer, clinical, mutational, allele, survival, prognostic, wang, mds, international, blood, jiang, system, httpsdoiorgleu, research, leukemic, yang, molecular, myeloid, revised, scoring, syndrome, mutations, privacy, cookies, content, analysis, information, journal, progression, tong, outcomes, study, access, author,

Topics {✒️}

month download article/chapter related subjects low-grade myelodysplastic syndromes tp53-mutated myelodysplastic syndromes lower-risk myelodysplastic syndromes international scoring system full article pdf myelodysplastic syndrome blood myeloid neoplasms primary myelodysplastic syndrome privacy choices/manage cookies article jiang acute myeloid leukemia hongyan tong molecular genetic diversity international working group clinical oncology aims improve prognostic prediction improve risk stratification predict prognosis independent improve predictive power electronic supplementary material faster leukemic transformation european economic area multivariate cox regression genomic context human cytogenetic nomenclature therapy center article journal check access instant access conditions privacy policy zhejiang university school additional information publisher' article log myelodysplastic syndrome international system generation sequencing—feasibility routine clinical prognostication leukemic progression lfs analyses revealed dnmt3a mutation 5-year survival prediction accepting optional cookies mutation status journal finder publish os-predicted nomogram leukemia-free survival article cite adding molecular data

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Bacher U, Kohlmann A, Haferlach T (2015) Mutational profiling in patients with MDS: ready for every-day use in the clinic?

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         headline:Predictive values of mutational variant allele frequency in overall survival and leukemic progression of myelodysplastic syndromes
         description:The implication of mutational variant allelic frequency (VAF) has been increasingly considered in the prognostic interpretation of molecular data in myeloid malignancies. However, the impact of VAF on outcomes of myelodysplastic syndromes (MDS) has not been extensively explored. Targeted next-generation sequencing was performed in 350 newly diagnosed MDS cases. The associations of mutational VAF of each gene with overall survival (OS) and leukemia-free survival (LFS) were examined by multivariate Cox regression after univariate analysis. Shorter OS was independently associated with DNMT3A VAF (HR 1.020 per 1% VAF increase; 95% CI 1.005–1.035; p = 0.011) and TP53 VAF (HR 1.014 per 1% VAF increase; 95% CI 1.006–1.022; p = 0.001). LFS analyses revealed that TET2 VAF (HR 1.013 per 1% VAF increase; 95% CI 1.005–1.022; p = 0.003) and TP53 VAF (HR 1.012 per 1% VAF increase; 95% CI 1.004–1.021; p = 0.005) were independently associated with faster leukemic transformation. Furthermore, we established nomograms to predict OS and LFS, respectively, by integrating independent mutational predictors into the revised International Prognostic Scoring System. Our study highlights that VAF of certain genes should be incorporated into routine clinical prognostication of survival and leukemic transformation of MDS.
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            Mutation
            Variant allele frequency
            Prognosis
            Leukemic progression
            Oncology
            Cancer Research
            Internal Medicine
            Hematology
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      headline:Predictive values of mutational variant allele frequency in overall survival and leukemic progression of myelodysplastic syndromes
      description:The implication of mutational variant allelic frequency (VAF) has been increasingly considered in the prognostic interpretation of molecular data in myeloid malignancies. However, the impact of VAF on outcomes of myelodysplastic syndromes (MDS) has not been extensively explored. Targeted next-generation sequencing was performed in 350 newly diagnosed MDS cases. The associations of mutational VAF of each gene with overall survival (OS) and leukemia-free survival (LFS) were examined by multivariate Cox regression after univariate analysis. Shorter OS was independently associated with DNMT3A VAF (HR 1.020 per 1% VAF increase; 95% CI 1.005–1.035; p = 0.011) and TP53 VAF (HR 1.014 per 1% VAF increase; 95% CI 1.006–1.022; p = 0.001). LFS analyses revealed that TET2 VAF (HR 1.013 per 1% VAF increase; 95% CI 1.005–1.022; p = 0.003) and TP53 VAF (HR 1.012 per 1% VAF increase; 95% CI 1.004–1.021; p = 0.005) were independently associated with faster leukemic transformation. Furthermore, we established nomograms to predict OS and LFS, respectively, by integrating independent mutational predictors into the revised International Prognostic Scoring System. Our study highlights that VAF of certain genes should be incorporated into routine clinical prognostication of survival and leukemic transformation of MDS.
      datePublished:2022-01-10T00:00:00Z
      dateModified:2022-01-10T00:00:00Z
      pageStart:845
      pageEnd:856
      sameAs:https://doi.org/10.1007/s00432-021-03905-y
      keywords:
         Myelodysplastic syndromes
         Mutation
         Variant allele frequency
         Prognosis
         Leukemic progression
         Oncology
         Cancer Research
         Internal Medicine
         Hematology
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      name:Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Myelodysplastic Syndromes Diagnosis and Therapy Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Myelodysplastic Syndromes Diagnosis and Therapy Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Myelodysplastic Syndromes Diagnosis and Therapy Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Myelodysplastic Syndromes Diagnosis and Therapy Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
      name:Myelodysplastic Syndromes Diagnosis and Therapy Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
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