We are analyzing https://link.springer.com/article/10.1007/s00432-012-1323-y.

Title:
Molecular markers of glioma: an update on recent progress and perspectives | Journal of Cancer Research and Clinical Oncology
Description:
Background Significant progress has been made in the molecular diagnostic subtyping of brain tumors especially gliomas. Designing effective tailored therapy remains the cornerstone for delving into the molecular heterogeneity and classification of gliomas. More homogenous tumor populations may lead to more uniform tumor responses in particular molecular constellation. Recent decade has seen a surge of molecular markers of glioma which hold a promise and potential of being strong prognostic, predictive, and diagnostic markers. They are also extremely critical for the stratification of current clinical trails. Method Review of the pertinent literature regarding the molecular markers of glioma was performed. Methods of detection of these markers and their clinical relevance are also discussed. Results and conclusions This review provides an update on progress and perspectives of these newest set of biomarkers which can also supplement and refine histological classification and serves as important prognostic and predictive markers; particularly relevant in this aspect are O6-methylguanine-DNA methyltransferase promoter methylation, IDH1 mutations, and codeletion of 1p/19q. BRAF fusion/mutations and EGFR amplification provide important clues diagnostically.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, google, scholar, pubmed, cas, cancer, gliomas, idh, molecular, glioblastoma, markers, brain, mutations, clin, oncol, prognostic, braf, gene, research, clinical, neuropathol, mgmt, patients, glioma, promoter, temozolomide, res, methylation, mutation, pathol, felsberg, pilocytic, tumors, predictive, acta, survival, med, analysis, anaplastic, glioblastomas, astrocytomas, multiforme, gupta, diagnostic, tumor, diagnostics, hartmann, human, engl, pathway,

Topics {✒️}

o6-methylguanine-dna methyltransferase month download article/chapter pediatric low-grade gliomas dna-repair gene mgmt α-ketoglutarate-dependent dioxygenases adult high-grade gliomas braf-kiaa1549 fusion transcripts kiaa1549-braf fusion transcripts common glioma-derived mutation central nervous system specific genetic predictors raf-erk signaling pathway full article pdf dependent isocitrate dehydrogenase high-grade gliomas integrated genomic analysis extra-cerebellar pilocytic astrocytoma kirti gupta signature genetic defect predictive molecular markers anti-o6-methylguaninemethyltransferase privacy choices/manage cookies article gupta 1p19q codeleted gliomas mgmt promoter methylation prognostic factor analysis jones dt idh2 mutation status 1p/19q codeletion oncogenic fusion gene idh1-r132s mutation chromosome 1p losses cpg island hypermethylation diagnostic markers braf v600e mutation molecular diagnostic subtyping molecular diagnostic testing braf gene fusion randomized european organisation isocitrate dehydrogenase mutations pilocytic astrocytomas diagnosed ncic trial 26981–22981/ce egfr kinase inhibitors erk/mapk pathway oncogenic raf1 rearrangement gene expression clinical trial substantiates recurrent anaplastic astrocytoma clinical oncology aims juvenile pilocytic astrocytomas

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Molecular markers of glioma: an update on recent progress and perspectives
         description:Significant progress has been made in the molecular diagnostic subtyping of brain tumors especially gliomas. Designing effective tailored therapy remains the cornerstone for delving into the molecular heterogeneity and classification of gliomas. More homogenous tumor populations may lead to more uniform tumor responses in particular molecular constellation. Recent decade has seen a surge of molecular markers of glioma which hold a promise and potential of being strong prognostic, predictive, and diagnostic markers. They are also extremely critical for the stratification of current clinical trails. Review of the pertinent literature regarding the molecular markers of glioma was performed. Methods of detection of these markers and their clinical relevance are also discussed. This review provides an update on progress and perspectives of these newest set of biomarkers which can also supplement and refine histological classification and serves as important prognostic and predictive markers; particularly relevant in this aspect are O6-methylguanine-DNA methyltransferase promoter methylation, IDH1 mutations, and codeletion of 1p/19q. BRAF fusion/mutations and EGFR amplification provide important clues diagnostically.
         datePublished:2012-10-06T00:00:00Z
         dateModified:2012-10-06T00:00:00Z
         pageStart:1971
         pageEnd:1981
         sameAs:https://doi.org/10.1007/s00432-012-1323-y
         keywords:
            Glioma
            Molecular markers
            Diagnostics
            Oncology
            Cancer Research
            Internal Medicine
            Hematology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-012-1323-y/MediaObjects/432_2012_1323_Fig1_HTML.gif
         isPartOf:
            name:Journal of Cancer Research and Clinical Oncology
            issn:
               1432-1335
               0171-5216
            volumeNumber:138
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Kirti Gupta
               affiliation:
                     name:Post Graduate Institute of Medical Education and Research (PGIMER)
                     address:
                        name:Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
                        type:PostalAddress
                     type:Organization
                     name:St Jude Children’s Research Hospital
                     address:
                        name:St Jude Children’s Research Hospital, Memphis, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Pravin Salunke
               affiliation:
                     name:Post Graduate Institute of Medical Education and Research (PGIMER)
                     address:
                        name:Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Molecular markers of glioma: an update on recent progress and perspectives
      description:Significant progress has been made in the molecular diagnostic subtyping of brain tumors especially gliomas. Designing effective tailored therapy remains the cornerstone for delving into the molecular heterogeneity and classification of gliomas. More homogenous tumor populations may lead to more uniform tumor responses in particular molecular constellation. Recent decade has seen a surge of molecular markers of glioma which hold a promise and potential of being strong prognostic, predictive, and diagnostic markers. They are also extremely critical for the stratification of current clinical trails. Review of the pertinent literature regarding the molecular markers of glioma was performed. Methods of detection of these markers and their clinical relevance are also discussed. This review provides an update on progress and perspectives of these newest set of biomarkers which can also supplement and refine histological classification and serves as important prognostic and predictive markers; particularly relevant in this aspect are O6-methylguanine-DNA methyltransferase promoter methylation, IDH1 mutations, and codeletion of 1p/19q. BRAF fusion/mutations and EGFR amplification provide important clues diagnostically.
      datePublished:2012-10-06T00:00:00Z
      dateModified:2012-10-06T00:00:00Z
      pageStart:1971
      pageEnd:1981
      sameAs:https://doi.org/10.1007/s00432-012-1323-y
      keywords:
         Glioma
         Molecular markers
         Diagnostics
         Oncology
         Cancer Research
         Internal Medicine
         Hematology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00432-012-1323-y/MediaObjects/432_2012_1323_Fig1_HTML.gif
      isPartOf:
         name:Journal of Cancer Research and Clinical Oncology
         issn:
            1432-1335
            0171-5216
         volumeNumber:138
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Kirti Gupta
            affiliation:
                  name:Post Graduate Institute of Medical Education and Research (PGIMER)
                  address:
                     name:Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
                     type:PostalAddress
                  type:Organization
                  name:St Jude Children’s Research Hospital
                  address:
                     name:St Jude Children’s Research Hospital, Memphis, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Pravin Salunke
            affiliation:
                  name:Post Graduate Institute of Medical Education and Research (PGIMER)
                  address:
                     name:Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Cancer Research and Clinical Oncology
      issn:
         1432-1335
         0171-5216
      volumeNumber:138
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Post Graduate Institute of Medical Education and Research (PGIMER)
      address:
         name:Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
         type:PostalAddress
      name:St Jude Children’s Research Hospital
      address:
         name:St Jude Children’s Research Hospital, Memphis, USA
         type:PostalAddress
      name:Post Graduate Institute of Medical Education and Research (PGIMER)
      address:
         name:Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Kirti Gupta
      affiliation:
            name:Post Graduate Institute of Medical Education and Research (PGIMER)
            address:
               name:Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
               type:PostalAddress
            type:Organization
            name:St Jude Children’s Research Hospital
            address:
               name:St Jude Children’s Research Hospital, Memphis, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Pravin Salunke
      affiliation:
            name:Post Graduate Institute of Medical Education and Research (PGIMER)
            address:
               name:Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
      name:St Jude Children’s Research Hospital, Memphis, USA
      name:Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(257)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

8.08s.

LINK . SPRINGER . COM {}