We are analyzing https://link.springer.com/article/10.1007/s00430-015-0407-0.

Title:
Sepsis and cytomegalovirus: foes or conspirators? | Medical Microbiology and Immunology
Description:
Cytomegalovirus (CMV) reactivation in non-immune-suppressed critically ill patients is an area of increasing interest. CMV has long been appreciated as a pathogen in immunocompromised hosts. CMV reactivates in approximately one-third of latently infected non-immune-suppressed hosts during critical illness; however, its role as a pathogen in these patients remains unclear. CMV reactivation has been linked to bacterial sepsis and likely results from inflammation, transient immune compromise, and viral epigenetic changes. While CMV may improve immune response to some bacterial infections, other data suggest that CMV induces exaggerated responses to severe infections that may be harmful to latently infected hosts. These results also suggest that previous infection history may explain significant differences seen between human septic responses and murine models of sepsis. While critically ill human hosts clearly have worse outcomes associated with CMV reactivation, determining causality remains an area of investigation, with randomized control trials currently being performed. Here we review the current literature and highlight areas for future investigation.
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Keywords {🔍}

pubmed, article, google, scholar, cytomegalovirus, cas, patients, reactivation, infection, med, central, care, cook, critically, ill, sepsis, human, immunocompetent, crit, virol, immunol, cmv, viral, mortality, infect, dis, latency, medical, bacterial, response, infections, access, intensive, active, reddehase, privacy, cookies, content, mansfield, hosts, septic, murine, host, unit, smith, herpes, herpesvirus, ferguson, cells, mice,

Topics {✒️}

month download article/chapter host response article medical microbiology improve immune response community-dwelling older adults heterologous t-cell immunity virus-specific cd8 memory interleukin-1{beta} triggers reactivation myd88-mediated signal transduction transient cd8-memory contraction mcdonald-smith gp full article pdf cardiovascular disease-related mortality polymerase chain reaction tumour necrosis factor intensive care unit privacy choices/manage cookies article mansfield critically ill patients intensive care patients harvard medical school pulmonary cytomegalovirus reactivation immune-suppressed hosts meta-analysis salivary gland virus human cytomegalovirus infection jeschke mg transient immune compromise previous infection history latent cytomegalovirus reactivation active cytomegalovirus infection stable cardiovascular disease human cytomegalovirus infections human cytomegalovirus major herpesvirus ebv dna end-organ disease prevent organ disease bacterial sepsis smith tf patients remains unclear human septic responses explain significant differences determining causality remains randomized control trials check access santo hayes tk major surgical resections caister academic pressnorfolk unifying hypothesis linking author information authors

Questions {❓}

Friedrichs I, Bingold T, Keppler OT, Pullmann B, Reinheimer C, Berger A (2013) Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract?
Sepsis and cytomegalovirus: foes or conspirators?
Sepsis and cytomegalovirus: foes or conspirators?
Traen S, Bochanen N, Ieven M, Schepens T, Bruynseels P, Verbrugghe W, Jorens PG (2014) Is acyclovir effective among critically ill patients with herpes simplex in the respiratory tract?

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