We are analyzing https://link.springer.com/article/10.1007/s004280050178.

Title:
Thymic myoid cell turnover in myasthenia gravis patients and in normal controls | Virchows Archiv
Description:
Thymic myoid cells (TMC) are sparse muscle-like cells in the thymic medulla, which are believed to trigger the autoimmune response in myasthenia gravis (MG). Ultrastructural investigations have revealed mature, degenerating, and immature TMC, but the number of TMC in MG patients does not differ from that in controls. We examined the turnover of TMC at the subcellular level, performing an immunocytochemical study with muscle-specific anti-desmin labelling of 10 thymuses derived from MG patients with lymphofollicular hyperplasia and from 8 normal controls. All thymuses examined revealed mature, immature, and degenerating TMC. Mature TMC contained desmin filaments in between Z-discs provided the sarcomeres were arranged in register. Morphological features of degenerating TMC included hypercontracted sarcomeres, cytoplasmic granular debris, chromatin clumping and, occasionally, membrane-bound bodies. Macrophages were not involved in the process. Immature TMC were of small diameter and contained myofilaments not arranged in myofibrils. In an MG thymus, small immature TMC were found clustered with dying TMC. It may be that degeneration of TMC is a stimulus for the generation of new TMC with faster turnover. This mechanism may mean that more antigen is available in MG patients than in normal controls, despite constant TMC numbers
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Telecommunications
Virtual Reality
Social Networks

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 8,170,236 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

tmc, article, cells, access, privacy, cookies, content, myasthenia, gravis, patients, controls, thymus, information, publish, search, thymic, myoid, turnover, normal, immature, open, data, log, journal, research, virchows, archiv, cell, bornemann, kirchner, mature, degenerating, discover, springer, optional, personal, parties, policy, find, track, april, cite, antje, thomas, explore, revealed, examined, thymuses, contained, desmin,

Topics {✒️}

muscle-specific anti-desmin labelling month download article/chapter single-cell profiling myasthenia gravis identifies article bornemann full article pdf myasthenia gravis patients virchows archiv 432 privacy choices/manage cookies related subjects mg thymus check access instant access myasthenia gravis european economic area z-discs provided cytoplasmic granular debris membrane-bound bodies conditions privacy policy constant tmc numbers accepting optional cookies sparse muscle article log thymic medulla cells journal finder publish april 1998 volume 432 small immature tmc article cite revealed mature faster turnover kirchner privacy policy personal data contained myofilaments books a 8 normal controls normal controls optional cookies manage preferences 10 thymuses derived degenerating tmc subscription content similar content data protection essential cookies cookies skip turnover small diameter institution subscribe

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Thymic myoid cell turnover in myasthenia gravis patients and in normal controls
         description: Thymic myoid cells (TMC) are sparse muscle-like cells in the thymic medulla, which are believed to trigger the autoimmune response in myasthenia gravis (MG). Ultrastructural investigations have revealed mature, degenerating, and immature TMC, but the number of TMC in MG patients does not differ from that in controls. We examined the turnover of TMC at the subcellular level, performing an immunocytochemical study with muscle-specific anti-desmin labelling of 10 thymuses derived from MG patients with lymphofollicular hyperplasia and from 8 normal controls. All thymuses examined revealed mature, immature, and degenerating TMC. Mature TMC contained desmin filaments in between Z-discs provided the sarcomeres were arranged in register. Morphological features of degenerating TMC included hypercontracted sarcomeres, cytoplasmic granular debris, chromatin clumping and, occasionally, membrane-bound bodies. Macrophages were not involved in the process. Immature TMC were of small diameter and contained myofilaments not arranged in myofibrils. In an MG thymus, small immature TMC were found clustered with dying TMC. It may be that degeneration of TMC is a stimulus for the generation of new TMC with faster turnover. This mechanism may mean that more antigen is available in MG patients than in normal controls, despite constant TMC numbers
         datePublished:
         dateModified:
         pageStart:357
         pageEnd:361
         sameAs:https://doi.org/10.1007/s004280050178
         keywords:
            Key words Thymus
            Myoid cells
            Desmin
            Myasthenia gravis
            Immunoelectron microscopy
            Pathology
         image:
         isPartOf:
            name:Virchows Archiv
            issn:
               1432-2307
               0945-6317
            volumeNumber:432
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Antje Bornemann
               affiliation:
                     name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
                     address:
                        name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas Kirchner
               affiliation:
                     name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
                     address:
                        name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Thymic myoid cell turnover in myasthenia gravis patients and in normal controls
      description: Thymic myoid cells (TMC) are sparse muscle-like cells in the thymic medulla, which are believed to trigger the autoimmune response in myasthenia gravis (MG). Ultrastructural investigations have revealed mature, degenerating, and immature TMC, but the number of TMC in MG patients does not differ from that in controls. We examined the turnover of TMC at the subcellular level, performing an immunocytochemical study with muscle-specific anti-desmin labelling of 10 thymuses derived from MG patients with lymphofollicular hyperplasia and from 8 normal controls. All thymuses examined revealed mature, immature, and degenerating TMC. Mature TMC contained desmin filaments in between Z-discs provided the sarcomeres were arranged in register. Morphological features of degenerating TMC included hypercontracted sarcomeres, cytoplasmic granular debris, chromatin clumping and, occasionally, membrane-bound bodies. Macrophages were not involved in the process. Immature TMC were of small diameter and contained myofilaments not arranged in myofibrils. In an MG thymus, small immature TMC were found clustered with dying TMC. It may be that degeneration of TMC is a stimulus for the generation of new TMC with faster turnover. This mechanism may mean that more antigen is available in MG patients than in normal controls, despite constant TMC numbers
      datePublished:
      dateModified:
      pageStart:357
      pageEnd:361
      sameAs:https://doi.org/10.1007/s004280050178
      keywords:
         Key words Thymus
         Myoid cells
         Desmin
         Myasthenia gravis
         Immunoelectron microscopy
         Pathology
      image:
      isPartOf:
         name:Virchows Archiv
         issn:
            1432-2307
            0945-6317
         volumeNumber:432
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Antje Bornemann
            affiliation:
                  name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
                  address:
                     name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Kirchner
            affiliation:
                  name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
                  address:
                     name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Virchows Archiv
      issn:
         1432-2307
         0945-6317
      volumeNumber:432
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
      address:
         name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
         type:PostalAddress
      name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
      address:
         name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Antje Bornemann
      affiliation:
            name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
            address:
               name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
               type:PostalAddress
            type:Organization
      name:Thomas Kirchner
      affiliation:
            name:Institute of Pathology, University of Erlangen-Nürnberg, Germany
            address:
               name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
      name:Institute of Pathology, University of Erlangen-Nürnberg, Germany, , DE
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(27)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.49s.

LINK . SPRINGER . COM {}