We are analyzing https://link.springer.com/article/10.1007/s00428-025-04029-1.

Title:
Pediatric cancer predisposition syndromes involving non-central nervous system solid pediatric tumors: a review on their manifestations with a focus on histopathology | Virchows Archiv
Description:
Germline genetic alterations and their associated cancer predisposition syndromes (CPS) are an important cause of pediatric cancer. Early recognition is of great importance for targeted surveillance, early detection, and prompt (personalized) therapeutic interventions. This review provides an overview of non-central nervous system solid pediatric tumor types, in relation to their associated CPS, with an emphasis on their histology. It serves as a guide for (pediatric) pathologists to increase their awareness of histological clues that suggest a CPS and warrant referral to the clinical geneticist.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Questions {❓}

Papathomas TG, Suurd DPD, Pacak K et al (2021) What have we learned from molecular biology of paragangliomas and pheochromocytomas?

Schema {🗺️}

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         description:Germline genetic alterations and their associated cancer predisposition syndromes (CPS) are an important cause of pediatric cancer. Early recognition is of great importance for targeted surveillance, early detection, and prompt (personalized) therapeutic interventions. This review provides an overview of non-central nervous system solid pediatric tumor types, in relation to their associated CPS, with an emphasis on their histology. It serves as a guide for (pediatric) pathologists to increase their awareness of histological clues that suggest a CPS and warrant referral to the clinical geneticist.
         datePublished:2025-01-23T00:00:00Z
         dateModified:2025-01-23T00:00:00Z
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      headline:Pediatric cancer predisposition syndromes involving non-central nervous system solid pediatric tumors: a review on their manifestations with a focus on histopathology
      description:Germline genetic alterations and their associated cancer predisposition syndromes (CPS) are an important cause of pediatric cancer. Early recognition is of great importance for targeted surveillance, early detection, and prompt (personalized) therapeutic interventions. This review provides an overview of non-central nervous system solid pediatric tumor types, in relation to their associated CPS, with an emphasis on their histology. It serves as a guide for (pediatric) pathologists to increase their awareness of histological clues that suggest a CPS and warrant referral to the clinical geneticist.
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               type:PostalAddress
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            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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               type:PostalAddress
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               type:PostalAddress
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      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Department of Pathology & Laboratory Medicine, University of Miami Miller School of Medicine, Miami, USA
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

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