We are analyzing https://link.springer.com/article/10.1007/s00428-020-02829-1.

Title:
Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen | Virchows Archiv
Description:
Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering of macrophages, prominent and diffuse neutrophilic margination within septal vessels, and interstitial inflammatory infiltrates, mainly represented by CD8+ T lymphocytes. These features are similar to those previously described in SARS-CoV-1 infection. Subtle histologic changes suggestive pulmonary involvement by Covid-19 may be accidentally encountered in routine pathology practice, especially when extensive sampling is performed for histology. These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients.
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Keywords {🔍}

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Topics {✒️}

ill-defined ground-glass opacities tiziano de giacomo pulmonary sars-cov-2 infection developed sars-cov-2 infection smoking-related interstitial fibrosis formalin-fixed specimen confirmed bassi massimiliano collected mild fibrous thickening article pernazza ground glass opacities ground-glass opacities sars-cov-1 infection sars-cov-2 infection sars-cov-2 infection [4 virus-related alterations chest ct findings polo pontino-sapienza university privacy choices/manage cookies mancini massimiliano contributed focal nuclear inclusion pre-operatory imaging sars-coronavirus outbreaks post-operative day amati giulia contributed mild inflammatory infiltrate rullo emma contributed subtle pulmonary histologic lung parenchyma surrounding major lung feature main histologic findings early lung involvement common antimalarial drug alveolar septal thickening lung cancer routine pathology practice diffuse alveolar damage early histologic findings zhonghua shi yan interstitial inflammatory infiltrates lung surgical specimens occasional fibrous plugs important intellectual content coronavirus-infected pneumonia ct scan massimiliano bassi current pandemic season global pandemic caused affected european country medical literature describing lymph node dissection

Schema {🗺️}

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         headline:Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen
         description:Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering of macrophages, prominent and diffuse neutrophilic margination within septal vessels, and interstitial inflammatory infiltrates, mainly represented by CD8+ T lymphocytes. These features are similar to those previously described in SARS-CoV-1 infection. Subtle histologic changes suggestive pulmonary involvement by Covid-19 may be accidentally encountered in routine pathology practice, especially when extensive sampling is performed for histology. These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients.
         datePublished:2020-04-30T00:00:00Z
         dateModified:2020-04-30T00:00:00Z
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      headline:Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen
      description:Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering of macrophages, prominent and diffuse neutrophilic margination within septal vessels, and interstitial inflammatory infiltrates, mainly represented by CD8+ T lymphocytes. These features are similar to those previously described in SARS-CoV-1 infection. Subtle histologic changes suggestive pulmonary involvement by Covid-19 may be accidentally encountered in routine pathology practice, especially when extensive sampling is performed for histology. These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients.
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