We are analyzing https://link.springer.com/article/10.1007/s00428-011-1056-3.

Title:
Precursor lesions of early onset pancreatic cancer | Virchows Archiv
Description:
Early onset pancreatic cancer (EOPC) constitutes less than 5% of all newly diagnosed cases of pancreatic cancer (PC). Although histopathological characteristics of EOPC have been described, no detailed reports on precursor lesions of EOPC are available. In the present study, we aimed to describe histopathological picture of extratumoral parenchyma in 23 cases of EOPCs (definition based on the threshold value of 45 years of age) with particular emphasis on two types of precursor lesions of PC: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs). The types, grades, and densities of precursor lesions of PC were compared in patients with EOPCs, in young patients with neuroendocrine neoplasms (NENs), and in older (at the age of 46 or more) patients with PC. PanINs were found in 95.6% of cases of EOPCs. PanINs-3 were found in 39.1% of EOPC cases. Densities of all PanIN grades in EOPC cases were larger than in young patients with NENs. Density of PanINs-1A in EOPC cases was larger than in older patients with PC, but densities of PanINs of other grades were comparable. IPMN was found only in a single patient with EOPC but in 20% of older patients with PC. PanINs are the most prevalent precursor lesions of EOPC. IPMNs are rarely precursor lesions of EOPC. Relatively high density of low-grade PanINs-1 in extratumoral parenchyma of patients with EOPC may result from unknown multifocal genetic alterations in pancreatic tissue in patients with EOPCs.
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Keywords {🔍}

patients, pancreatic, cases, panins, lesions, pcs, article, google, scholar, panin, older, eopc, density, epp, cancer, pubmed, precursor, study, eopcs, age, found, prevalence, present, mucinous, ipmns, nens, young, pancreas, densities, familial, tubular, complexes, fla, ductal, flas, patient, related, group, cell, duct, control, studied, cas, main, ducts, carcinoma, rate, higher, pathol, diagnosed,

Topics {✒️}

mucin-rich metaplastic cells article download pdf intraductal papillary-mucinous neoplasm pancreatic intra-epithelial neoplasia endocrine-ductular/ductuloinsular lesions transitional/squamous cell metaplasia young-onset pancreatic cancer invasive high-grade lesion pre-existing ducts high-grade incipient ipmns privacy choices/manage cookies pre-existing duct pancreatic intraepithelial neoplasms early pancreatic neoplasia pancreatic intraepithelial neoplasias centroacinar cell hyperplasia ewa zielińska-pająk pancreatic intraepithelial neoplasia armed forces institute early onset pc gastric foveolar-type ipmns centroacinar–acinar compartment acinar cell carcinoma ductal papillary hyperplasia including low-grade detectable pancreatic diseases open access main pancreatic ducts present-day panins-1a squamous cell metaplasias present-day panins-1b involving branch duct branch pancreatic ducts pancreatic cancer kindreds clinically detectable pc acinar cell nodules ductal epithelial lining mucinous cell hypertrophy acinar cell atrophy small pancreatic ducts pancreatic resections received familial pancreatic carcinoma panin-1b–fla complexes squamous cell metaplasia mucinous cystic neoplasms pancreatic duct hyperplasia endocrine cell hyperplasia main pancreatic duct dysplastic intraductal foci evident pancreatic diseases

Questions {❓}

Steinberg WM, Barkin JS, Bradley EL III, DiMagno E, Layer P, Canto MI, Levy MJ (2009) Should patients with a strong family history of pancreatic cancer be screened on a periodic basis for cancer of the pancreas?

Schema {🗺️}

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         headline:Precursor lesions of early onset pancreatic cancer
         description:Early onset pancreatic cancer (EOPC) constitutes less than 5% of all newly diagnosed cases of pancreatic cancer (PC). Although histopathological characteristics of EOPC have been described, no detailed reports on precursor lesions of EOPC are available. In the present study, we aimed to describe histopathological picture of extratumoral parenchyma in 23 cases of EOPCs (definition based on the threshold value of 45 years of age) with particular emphasis on two types of precursor lesions of PC: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs). The types, grades, and densities of precursor lesions of PC were compared in patients with EOPCs, in young patients with neuroendocrine neoplasms (NENs), and in older (at the age of 46 or more) patients with PC. PanINs were found in 95.6% of cases of EOPCs. PanINs-3 were found in 39.1% of EOPC cases. Densities of all PanIN grades in EOPC cases were larger than in young patients with NENs. Density of PanINs-1A in EOPC cases was larger than in older patients with PC, but densities of PanINs of other grades were comparable. IPMN was found only in a single patient with EOPC but in 20% of older patients with PC. PanINs are the most prevalent precursor lesions of EOPC. IPMNs are rarely precursor lesions of EOPC. Relatively high density of low-grade PanINs-1 in extratumoral parenchyma of patients with EOPC may result from unknown multifocal genetic alterations in pancreatic tissue in patients with EOPCs.
         datePublished:2011-03-03T00:00:00Z
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            Pancreatic neoplasms
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            Pathology
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      headline:Precursor lesions of early onset pancreatic cancer
      description:Early onset pancreatic cancer (EOPC) constitutes less than 5% of all newly diagnosed cases of pancreatic cancer (PC). Although histopathological characteristics of EOPC have been described, no detailed reports on precursor lesions of EOPC are available. In the present study, we aimed to describe histopathological picture of extratumoral parenchyma in 23 cases of EOPCs (definition based on the threshold value of 45 years of age) with particular emphasis on two types of precursor lesions of PC: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs). The types, grades, and densities of precursor lesions of PC were compared in patients with EOPCs, in young patients with neuroendocrine neoplasms (NENs), and in older (at the age of 46 or more) patients with PC. PanINs were found in 95.6% of cases of EOPCs. PanINs-3 were found in 39.1% of EOPC cases. Densities of all PanIN grades in EOPC cases were larger than in young patients with NENs. Density of PanINs-1A in EOPC cases was larger than in older patients with PC, but densities of PanINs of other grades were comparable. IPMN was found only in a single patient with EOPC but in 20% of older patients with PC. PanINs are the most prevalent precursor lesions of EOPC. IPMNs are rarely precursor lesions of EOPC. Relatively high density of low-grade PanINs-1 in extratumoral parenchyma of patients with EOPC may result from unknown multifocal genetic alterations in pancreatic tissue in patients with EOPCs.
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         Pancreas
         Pancreatic neoplasms
         Pancreatic ductal carcinoma
         Pancreatic ducts
         Intraepithelial carcinoma
         Pathology
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