We are analyzing https://link.springer.com/article/10.1007/s00428-006-0213-6.

Title:
Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer | Virchows Archiv
Description:
The purpose of this study was to investigate the influence of androgen receptor (AR) expression in tumour tissue on survival of patients with metastatic breast cancer. Tumour specimens from 232 patients with metastatic breast cancer were examined for presence of AR by immunohistochemistry. According to the extent of immunostaining, AR expression was classified as score 0, 1+, 2+, or 3+. AR positivity was observed in 164 (70.7%) tumours. The median survival after disease recurrence (SAR) of patients with AR-expressing tumours was significantly longer compared to that of patients with AR-negative tumours (21.89 months, 95% CI 17.23–26.55 vs 11.99 months, 95% CI 9.36–14.62; log-rank test 0.0282). In addition, patients with AR score 3+ had a significantly longer disease-free survival (DFS) compared to patients with AR score 0, 1+, and 2+, (24.67 months, 95% CI 13.72–35.62 vs 16.36 months, 95% CI 13.18–19.54, log-rank test 0.0043). Multivariate Cox analyses showed no statistically significant influence of AR expression on DFS or SAR. In conclusion, SAR is significantly longer in patients with AR-expressing breast carcinoma. However, AR expression is not an independent prognostic factor for SAR in metastatic breast cancer.
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Keywords {🔍}

cancer, breast, article, pubmed, google, scholar, cas, prognostic, androgen, receptor, expression, receptors, patients, metastatic, estrogen, survival, access, study, privacy, cookies, content, carcinoma, factors, publish, search, virchows, significance, schippinger, regitnig, sar, months, open, immunohistochemical, oncol, graz, data, information, log, journal, research, april, walter, dandachi, moinfar, score, tumours, recurrence, significantly, longer, discover,

Topics {✒️}

month download article/chapter population-based study ar-expressing breast carcinoma related subjects metastatic breast carcinoma full article pdf prognostic markers metastatic breast cancer privacy choices/manage cookies national cancer institute pathological prognostic factors androgen receptor expression klaus-dieter wernecke androgen receptor activity breast cancer mortality human breast cancer operable breast cancer primary breast cancer hormone receptor status progesterone receptor levels progesterone receptor status progestogen receptor activity benign breast tumors independent prognostic factor joint estrogen receptor check access instant access breast cancer classified european economic area multivariate analysis approach long-term follow van der kwast henzen-logmans sc cell biological parameters adjuvant tamoxifen treatment article schippinger androgen receptors frequently conditions privacy policy significantly longer compared stanford jl disease recurrence phase ii study log-rank test 0 article log ar-negative tumours sledge gw jr breast carcinoma early recurrence accepting optional cookies ar-expressing tumours

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         headline:Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer
         description:The purpose of this study was to investigate the influence of androgen receptor (AR) expression in tumour tissue on survival of patients with metastatic breast cancer. Tumour specimens from 232 patients with metastatic breast cancer were examined for presence of AR by immunohistochemistry. According to the extent of immunostaining, AR expression was classified as score 0, 1+, 2+, or 3+. AR positivity was observed in 164 (70.7%) tumours. The median survival after disease recurrence (SAR) of patients with AR-expressing tumours was significantly longer compared to that of patients with AR-negative tumours (21.89 months, 95% CI 17.23–26.55 vs 11.99 months, 95% CI 9.36–14.62; log-rank test 0.0282). In addition, patients with AR score 3+ had a significantly longer disease-free survival (DFS) compared to patients with AR score 0, 1+, and 2+, (24.67 months, 95% CI 13.72–35.62 vs 16.36 months, 95% CI 13.18–19.54, log-rank test 0.0043). Multivariate Cox analyses showed no statistically significant influence of AR expression on DFS or SAR. In conclusion, SAR is significantly longer in patients with AR-expressing breast carcinoma. However, AR expression is not an independent prognostic factor for SAR in metastatic breast cancer.
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