We are analyzing https://link.springer.com/article/10.1007/s00428-005-0003-6.

Title:
Immunohistochemical study of androgen receptors in breast carcinoma. Evidence of their frequent expression in lobular carcinoma | Virchows Archiv
Description:
Androgens and androgen receptors (AR) are involved in the pathogenesis of breast cancer. Epidemiological studies have shown a significant association between the risk of breast cancer and androgens. However, the functional role and clinical value of AR expression in breast carcinoma have still not been clearly defined. The present study was set up to investigate the prevalence of ARs in a series of consecutive invasive breast carcinomas (IBCs) and to evaluate the patterns of AR phenotypes in a series of selected invasive lobular carcinomas (ILCs). Among the 250 consecutive IBCs (consisting of 212 ductal and 38 lobular neoplasms), AR immunoreactivity was observed in 151/250 (60.4%) cases, being expressed in 118/212 (56%) ductal and 33/38 (87%) lobular carcinomas (a statistically significant difference, χ2=11.82). AR expression was frequently associated with ER (65.2%, χ2=14.33) and PR positivity (66.9%, χ2=7.36). Most AR positive cases showed a low proliferative index (63.7%) and a low or intermediate histological grade (G1–G2, 63.9%). Among the 80 selected ILCs, AR expression was observed in 64/80 (80%) cases. Our results confirm that ARs are expressed in most breast cancers. Moreover, we demonstrated that AR positivity is particularly marked in lobular neoplasms. In addition, AR positive carcinomas are frequently characterized by a low or intermediate grade, a low proliferative index and ER and/or PR co-expression.
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Keywords {🔍}

cancer, breast, google, scholar, article, pubmed, cas, androgen, receptors, receptor, carcinoma, lobular, progesterone, res, expression, prognostic, human, estrogen, hormone, immunohistochemical, risk, access, oestrogen, relation, privacy, cookies, content, carcinomas, ductal, women, pathol, steroid, pathology, publish, research, search, study, riva, androgens, role, low, apocrine, int, university, data, information, log, journal, virchows, cristina,

Topics {✒️}

month download article/chapter paraffin-embedded human tissue paolo cossu rocca long-term tissue culture full article pdf privacy choices/manage cookies hormone replacement therapy steroid hormone receptors steroid-hormone receptors human breast cancer pleomorphic lobular carcinoma operable breast cancer lobular breast cancer breast cancers elevated serum estradiol subsequent breast cancer female breast cancer long-term follow long term follow apocrine breast lesions ar positive carcinomas european economic area giovanni massarelli van putten wlj medroxyprogesterone acetate inhibits cushing-haugen kl endogenous sex hormones comparative genomic hybridization lea oa adjuvant tamoxifen treatment female genital organs van gilse ha progestin-induced regression mc guire wl progesterone receptor determinations article riva ductal breast carcinoma androgen receptor activation androgen receptor accompanied conditions privacy policy progesterone receptors measured statistically significant difference de ruiter pe western blot studies tavassoli fa progesterone receptor determination androgen receptor status check access instant access article log

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         headline:Immunohistochemical study of androgen receptors in breast carcinoma. Evidence of their frequent expression in lobular carcinoma
         description:Androgens and androgen receptors (AR) are involved in the pathogenesis of breast cancer. Epidemiological studies have shown a significant association between the risk of breast cancer and androgens. However, the functional role and clinical value of AR expression in breast carcinoma have still not been clearly defined. The present study was set up to investigate the prevalence of ARs in a series of consecutive invasive breast carcinomas (IBCs) and to evaluate the patterns of AR phenotypes in a series of selected invasive lobular carcinomas (ILCs). Among the 250 consecutive IBCs (consisting of 212 ductal and 38 lobular neoplasms), AR immunoreactivity was observed in 151/250 (60.4%) cases, being expressed in 118/212 (56%) ductal and 33/38 (87%) lobular carcinomas (a statistically significant difference, χ2=11.82). AR expression was frequently associated with ER (65.2%, χ2=14.33) and PR positivity (66.9%, χ2=7.36). Most AR positive cases showed a low proliferative index (63.7%) and a low or intermediate histological grade (G1–G2, 63.9%). Among the 80 selected ILCs, AR expression was observed in 64/80 (80%) cases. Our results confirm that ARs are expressed in most breast cancers. Moreover, we demonstrated that AR positivity is particularly marked in lobular neoplasms. In addition, AR positive carcinomas are frequently characterized by a low or intermediate grade, a low proliferative index and ER and/or PR co-expression.
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