We are analyzing https://link.springer.com/article/10.1007/s004270050191.

Title:
Pax-6 origins – implications from the structure of two coral Pax genes | Discover Developmental Biology
Description:
Vertebrate Pax-6 and its Drosophila homolog eyeless play central roles in eye specification, although it is not clear if this represents the ancestral role of this gene class. As the most ”primitive” animals with true nervous systems, the Cnidaria may be informative in terms of the evolution of the Pax gene family. For this reason we surveyed the Pax gene complement of a representative of the basal cnidarian class (the Anthozoa), the coral Acropora millepora. cDNAs encoding two coral Pax proteins were isolated. Pax-Aam encoded a protein containing only a paired domain, whereas Pax-Cam also contained a homeodomain clearly related to those in the Pax-6 family. The paired domains in both proteins most resembled the vertebrate Pax-2/5/8 class, but shared several distinctive substitutions. As in most Pax-6 homologs and orthologs, an intron was present in the Pax-Cam locus at a position corresponding to residues 46/47 in the homeodomain. We propose a model for evolution of the Pax family, in which the ancestor of all of the vertebrate Pax genes most resembled Pax-6, and arose via fusion of a Pax-Aam-like gene (encoding only a paired domain) with an anteriorly-expressed homeobox gene resembling the paired -like class.
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Keywords {🔍}

pax, genes, article, gene, evolution, privacy, cookies, coral, family, paired, content, information, publish, research, search, class, data, journal, download, catmull, hayward, mcintyre, vertebrate, related, discover, university, optional, analysis, personal, parties, policy, find, track, development, origins, implications, structure, cite, pdf, manuscript, naomi, john, reecehoyes, rebecca, mastro, callaerts, eldon, ball, miller, explore,

Topics {✒️}

coral pax genes vertebrate pax genes coral acropora millepora pax family genes privacy choices/manage cookies molecular biology coral pax proteins pax gene complement main content log pax gene family european economic area true nervous systems vertebrate pax-2/5/8 class pax-aam encoded pax-cam locus conditions privacy policy related subjects evolution aims james cook university australian national university basal cnidarian class accepting optional cookies scope submit manuscript journal finder publish pax6 mutations search search evolution article cite article catmull eye specification pax-6 family pax family pax-cam pax-aam gene class privacy policy personal data books a pax-6 homologs information paired domain paired domains optional cookies manage preferences resembled pax-6 data protection essential cookies cookies skip journal publish social media

Schema {🗺️}

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         headline:Pax-6 origins – implications from the structure of two coral Pax genes
         description: Vertebrate Pax-6 and its Drosophila homolog eyeless play central roles in eye specification, although it is not clear if this represents the ancestral role of this gene class. As the most ”primitive” animals with true nervous systems, the Cnidaria may be informative in terms of the evolution of the Pax gene family. For this reason we surveyed the Pax gene complement of a representative of the basal cnidarian class (the Anthozoa), the coral Acropora millepora. cDNAs encoding two coral Pax proteins were isolated. Pax-Aam encoded a protein containing only a paired domain, whereas Pax-Cam also contained a homeodomain clearly related to those in the Pax-6 family. The paired domains in both proteins most resembled the vertebrate Pax-2/5/8 class, but shared several distinctive substitutions. As in most Pax-6 homologs and orthologs, an intron was present in the Pax-Cam locus at a position corresponding to residues 46/47 in the homeodomain. We propose a model for evolution of the Pax family, in which the ancestor of all of the vertebrate Pax genes most resembled Pax-6, and arose via fusion of a Pax-Aam-like gene (encoding only a paired domain) with an anteriorly-expressed homeobox gene resembling the paired -like class.
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      headline:Pax-6 origins – implications from the structure of two coral Pax genes
      description: Vertebrate Pax-6 and its Drosophila homolog eyeless play central roles in eye specification, although it is not clear if this represents the ancestral role of this gene class. As the most ”primitive” animals with true nervous systems, the Cnidaria may be informative in terms of the evolution of the Pax gene family. For this reason we surveyed the Pax gene complement of a representative of the basal cnidarian class (the Anthozoa), the coral Acropora millepora. cDNAs encoding two coral Pax proteins were isolated. Pax-Aam encoded a protein containing only a paired domain, whereas Pax-Cam also contained a homeodomain clearly related to those in the Pax-6 family. The paired domains in both proteins most resembled the vertebrate Pax-2/5/8 class, but shared several distinctive substitutions. As in most Pax-6 homologs and orthologs, an intron was present in the Pax-Cam locus at a position corresponding to residues 46/47 in the homeodomain. We propose a model for evolution of the Pax family, in which the ancestor of all of the vertebrate Pax genes most resembled Pax-6, and arose via fusion of a Pax-Aam-like gene (encoding only a paired domain) with an anteriorly-expressed homeobox gene resembling the paired -like class.
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      dateModified:
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      pageEnd:356
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      name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
      name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
      name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
      name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
      name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland, , CH
      name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
      name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU

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