We are analyzing https://link.springer.com/article/10.1007/s00424-003-1104-1.

Title:
Sodium-dependent ascorbic acid transporter family SLC23 | Pflügers Archiv - European Journal of Physiology
Description:
l-Ascorbic acid (vitamin C) is an effective antioxidant and an essential cofactor in numerous enzymatic reactions. Two Na+-dependent vitamin C transporters (SVCT1 and SVCT2) are members of the SLC23 human gene family, which also contains two orphan members. SVCT1 and SVCT2 display similar properties, including high affinity for l-ascorbic acid, but are discretely distributed. SVCT1 is confined to epithelial systems including intestine, kidney, and liver, whereas SVCT2 serves a host of metabolically active and specialized cells and tissues including neurons, the eye, lung, and placenta, and a range of neuroendocrine, exocrine, and endothelial tissues. An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear.
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Topics {✒️}

[125i]6-deoxy-6-iodo-l-ascorbic acid month download article/chapter electrogenic na+-ascorbate cotransport c14-labelled ascorbic acid human sodium-dependent vitamin human na+-dependent vitamin llc-pk1 cells reveals anoxia-tolerant reptiles contrasted position-specific gap penalties ascorbic-acid transporter slc23a1 ascorbate-specific transport properties l-ascorbic acid high-affinity sodium-vitamin sodium-dependent vitamin dehydroascorbic acid transport svct2-knockout mouse reveals na+-dependent vitamin full article pdf dehydroascorbic acid measurements ascorbic acid levels privacy choices/manage cookies rumsey sc cell line kg-1 transporter family conserved sodium-coupled vitamin ocular ascorbate transport article takanaga including high affinity transporter remain unclear human nucleobase transporter ascorbic acid display phylogenetic trees anoxia-intolerant species dehydroascorbic acid aspergillus nucleobase transporters european economic area numerous enzymatic reactions related subjects wilson jx free radical scavengers isolated rat adipocytes harvard medical school check access instant access conditions privacy policy hugo gene names li x-cm embryonic mouse neurons functional splice variant tissues including neurons

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         description: l-Ascorbic acid (vitamin C) is an effective antioxidant and an essential cofactor in numerous enzymatic reactions. Two Na+-dependent vitamin C transporters (SVCT1 and SVCT2) are members of the SLC23 human gene family, which also contains two orphan members. SVCT1 and SVCT2 display similar properties, including high affinity for l-ascorbic acid, but are discretely distributed. SVCT1 is confined to epithelial systems including intestine, kidney, and liver, whereas SVCT2 serves a host of metabolically active and specialized cells and tissues including neurons, the eye, lung, and placenta, and a range of neuroendocrine, exocrine, and endothelial tissues. An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear.
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            Ascorbic acid transport
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            Neuron
            Oxidative stress
            Scurvy
            Human Physiology
            Molecular Medicine
            Neurosciences
            Cell Biology
            Receptors
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      headline:Sodium-dependent ascorbic acid transporter family SLC23
      description: l-Ascorbic acid (vitamin C) is an effective antioxidant and an essential cofactor in numerous enzymatic reactions. Two Na+-dependent vitamin C transporters (SVCT1 and SVCT2) are members of the SLC23 human gene family, which also contains two orphan members. SVCT1 and SVCT2 display similar properties, including high affinity for l-ascorbic acid, but are discretely distributed. SVCT1 is confined to epithelial systems including intestine, kidney, and liver, whereas SVCT2 serves a host of metabolically active and specialized cells and tissues including neurons, the eye, lung, and placenta, and a range of neuroendocrine, exocrine, and endothelial tissues. An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear.
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         Oxidative stress
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         Cell Biology
         Receptors
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