We are analyzing https://link.springer.com/article/10.1007/s00424-003-1018-y.

Title:
Ion selectivity of stretch-activated cation currents in mouse ventricular myocytes | Pflügers Archiv - European Journal of Physiology
Description:
Stretch-activated non-selective cation currents (I SAC) constitute a mechanism that can induce cardiac arrhythmias. We studied I SAC in mouse ventricular myocytes by stretching part of the cell surface between the patch-pipette and a motor-driven glass stylus. In non-clamped cells, local stretch depolarised and induced after-depolarisations and extrasystoles. In voltage-clamped cells (K+ currents suppressed) I SAC activated by local stretch had a nearly linear voltage dependence and reversed polarity between −12 and 0 mV. Conductance G SAC increased with the extent of local stretch. I SAC was not a Cl− current (insensitivity to replacement of Cl− by aspartate−). I SAC was not a Ca2+-activated current (insensitivity to 5 mM intracellular BAPTA). G SAC was blocked by 5 µM GdCl3 or by 75 mM extracellular (e.c.) CaCl2. Removal of e.c. CaCl2 increased G SAC 2.5-fold, as if G SAC were sensitive to Ca2+ and Gd3+. Replacement of 150 mM e.c. Na+ by 150 mM Cs+, Li+, tetraethylammonium (TEA+) or N-methyl d-glucosamine (NMDG+) yielded currents that suggested for the conductance a selectivity G Cs>G Na>G Li>G TEA>G NMDG. I SAC was suppressed by cytochalasin D, as if an intact F-actin cytoskeleton were necessary for activation of I SAC.
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Keywords {🔍}

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Topics {✒️}

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         description:Stretch-activated non-selective cation currents (I SAC) constitute a mechanism that can induce cardiac arrhythmias. We studied I SAC in mouse ventricular myocytes by stretching part of the cell surface between the patch-pipette and a motor-driven glass stylus. In non-clamped cells, local stretch depolarised and induced after-depolarisations and extrasystoles. In voltage-clamped cells (K+ currents suppressed) I SAC activated by local stretch had a nearly linear voltage dependence and reversed polarity between −12 and 0 mV. Conductance G SAC increased with the extent of local stretch. I SAC was not a Cl− current (insensitivity to replacement of Cl− by aspartate−). I SAC was not a Ca2+-activated current (insensitivity to 5 mM intracellular BAPTA). G SAC was blocked by 5 µM GdCl3 or by 75 mM extracellular (e.c.) CaCl2. Removal of e.c. CaCl2 increased G SAC 2.5-fold, as if G SAC were sensitive to Ca2+ and Gd3+. Replacement of 150 mM e.c. Na+ by 150 mM Cs+, Li+, tetraethylammonium (TEA+) or N-methyl d-glucosamine (NMDG+) yielded currents that suggested for the conductance a selectivity G Cs>G Na>G Li>G TEA>G NMDG. I SAC was suppressed by cytochalasin D, as if an intact F-actin cytoskeleton were necessary for activation of I SAC.
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            Receptors
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         Neurosciences
         Cell Biology
         Receptors
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