We are analyzing https://link.springer.com/article/10.1007/s00418-016-1527-3.

Title:
Functional characterisation of the YIPF protein family in mammalian cells | Histochemistry and Cell Biology
Description:
In this study, we carry out a systematic characterisation of the YIPF family of proteins with respect to their subcellular localisation profile, membrane topology and functional effects on the endomembrane system. YIPF proteins primarily localise to the Golgi complex and can be grouped into trans-Golgi-localising YIPFs (YIPF1 and YIPF2) and cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5), with YIPF6 and YIPF7 showing a broader profile being distributed throughout the Golgi stack. YIPF proteins have a long soluble N-terminal region, which is orientated towards the cytosol, followed by 5 closely stacked transmembrane domains, and a C terminus, orientated towards the lumen of the Golgi. The significance of YIPF proteins for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion. We propose a role for this family of proteins in regulating membrane dynamics in the endomembrane system.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

pubmed, article, google, scholar, cas, cell, proteins, yipf, golgi, biol, central, protein, membrane, family, simpson, rab, dublin, complex, access, transport, science, endoplasmic, university, privacy, cookies, content, research, kranjc, nat, brefeldin, reticulum, pathway, secretory, ireland, college, function, publish, search, biology, functional, cells, tilen, dempsey, cagney, jeremy, role, open, nature, chem, human,

Topics {✒️}

intermediate compartment/cis-golgi network month download article/chapter gtp-binding proteins related proteome-wide protein quantification subcellular localisation profile cis-golgi-localising yipfs trans-golgi-localising yipfs copi-independent retrograde transport microtubule-dependent retrograde transport rab9-mediated vesicle transport endoplasmic reticulum-derived vesicles related subjects full article pdf membrane traffic membrane protein enriched yipf protein family regulating membrane dynamics privacy choices/manage cookies gtp-binding mutants family-wide characterization high-throughput method itinerant golgi proteins sec4 products involved lippincott-schwartz article kranjc irish research council cis-golgi compartments check access instant access article histochemistry mammalian endoplasmic reticulum cis-snare complex cellular binding partner endoplasmic reticulum dysfunction transport gtpases ypt1p quantifying cell phenotypes european economic area range mass accuracies copii vesicle biogenesis cultured rat hepatocytes threshold selection method gray-level histograms development core team mhc class ii yoshimura s yif1a recycle ethics declarations conflict intracellular vesicle transport cell biology aims er–golgi intermediate

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Functional characterisation of the YIPF protein family in mammalian cells
         description:In this study, we carry out a systematic characterisation of the YIPF family of proteins with respect to their subcellular localisation profile, membrane topology and functional effects on the endomembrane system. YIPF proteins primarily localise to the Golgi complex and can be grouped into trans-Golgi-localising YIPFs (YIPF1 and YIPF2) and cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5), with YIPF6 and YIPF7 showing a broader profile being distributed throughout the Golgi stack. YIPF proteins have a long soluble N-terminal region, which is orientated towards the cytosol, followed by 5 closely stacked transmembrane domains, and a C terminus, orientated towards the lumen of the Golgi. The significance of YIPF proteins for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion. We propose a role for this family of proteins in regulating membrane dynamics in the endomembrane system.
         datePublished:2016-12-20T00:00:00Z
         dateModified:2016-12-20T00:00:00Z
         pageStart:439
         pageEnd:451
         sameAs:https://doi.org/10.1007/s00418-016-1527-3
         keywords:
            YIPF
            Transmembrane proteins
            Subcellular localisation
            Membrane traffic
            Golgi apparatus
            Biomedicine
            general
            Cell Biology
            Biochemistry
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig6_HTML.gif
         isPartOf:
            name:Histochemistry and Cell Biology
            issn:
               1432-119X
               0948-6143
            volumeNumber:147
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Tilen Kranjc
               affiliation:
                     name:University College Dublin
                     address:
                        name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
                     name:University College Dublin
                     address:
                        name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
                     name:University of Ljubljana
                     address:
                        name:Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eugene Dempsey
               affiliation:
                     name:University College Dublin
                     address:
                        name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
                     name:University College Dublin
                     address:
                        name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gerard Cagney
               affiliation:
                     name:University College Dublin
                     address:
                        name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
                     name:University College Dublin
                     address:
                        name:School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nobuhiro Nakamura
               affiliation:
                     name:Kyoto Sangyo University
                     address:
                        name:Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Denis C. Shields
               affiliation:
                     name:University College Dublin
                     address:
                        name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
                     name:University College Dublin
                     address:
                        name:School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jeremy C. Simpson
               url:http://orcid.org/0000-0002-7956-7805
               affiliation:
                     name:University College Dublin
                     address:
                        name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
                     name:University College Dublin
                     address:
                        name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Functional characterisation of the YIPF protein family in mammalian cells
      description:In this study, we carry out a systematic characterisation of the YIPF family of proteins with respect to their subcellular localisation profile, membrane topology and functional effects on the endomembrane system. YIPF proteins primarily localise to the Golgi complex and can be grouped into trans-Golgi-localising YIPFs (YIPF1 and YIPF2) and cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5), with YIPF6 and YIPF7 showing a broader profile being distributed throughout the Golgi stack. YIPF proteins have a long soluble N-terminal region, which is orientated towards the cytosol, followed by 5 closely stacked transmembrane domains, and a C terminus, orientated towards the lumen of the Golgi. The significance of YIPF proteins for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion. We propose a role for this family of proteins in regulating membrane dynamics in the endomembrane system.
      datePublished:2016-12-20T00:00:00Z
      dateModified:2016-12-20T00:00:00Z
      pageStart:439
      pageEnd:451
      sameAs:https://doi.org/10.1007/s00418-016-1527-3
      keywords:
         YIPF
         Transmembrane proteins
         Subcellular localisation
         Membrane traffic
         Golgi apparatus
         Biomedicine
         general
         Cell Biology
         Biochemistry
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-016-1527-3/MediaObjects/418_2016_1527_Fig6_HTML.gif
      isPartOf:
         name:Histochemistry and Cell Biology
         issn:
            1432-119X
            0948-6143
         volumeNumber:147
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Tilen Kranjc
            affiliation:
                  name:University College Dublin
                  address:
                     name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
                  name:University College Dublin
                  address:
                     name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
                  name:University of Ljubljana
                  address:
                     name:Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eugene Dempsey
            affiliation:
                  name:University College Dublin
                  address:
                     name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
                  name:University College Dublin
                  address:
                     name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gerard Cagney
            affiliation:
                  name:University College Dublin
                  address:
                     name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
                  name:University College Dublin
                  address:
                     name:School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nobuhiro Nakamura
            affiliation:
                  name:Kyoto Sangyo University
                  address:
                     name:Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Denis C. Shields
            affiliation:
                  name:University College Dublin
                  address:
                     name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
                  name:University College Dublin
                  address:
                     name:School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jeremy C. Simpson
            url:http://orcid.org/0000-0002-7956-7805
            affiliation:
                  name:University College Dublin
                  address:
                     name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
                  name:University College Dublin
                  address:
                     name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Histochemistry and Cell Biology
      issn:
         1432-119X
         0948-6143
      volumeNumber:147
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University College Dublin
      address:
         name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University College Dublin
      address:
         name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University of Ljubljana
      address:
         name:Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
         type:PostalAddress
      name:University College Dublin
      address:
         name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University College Dublin
      address:
         name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University College Dublin
      address:
         name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University College Dublin
      address:
         name:School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:Kyoto Sangyo University
      address:
         name:Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan
         type:PostalAddress
      name:University College Dublin
      address:
         name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University College Dublin
      address:
         name:School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University College Dublin
      address:
         name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
      name:University College Dublin
      address:
         name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Tilen Kranjc
      affiliation:
            name:University College Dublin
            address:
               name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
            name:University College Dublin
            address:
               name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
            name:University of Ljubljana
            address:
               name:Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
               type:PostalAddress
            type:Organization
      name:Eugene Dempsey
      affiliation:
            name:University College Dublin
            address:
               name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
            name:University College Dublin
            address:
               name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
      name:Gerard Cagney
      affiliation:
            name:University College Dublin
            address:
               name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
            name:University College Dublin
            address:
               name:School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
      name:Nobuhiro Nakamura
      affiliation:
            name:Kyoto Sangyo University
            address:
               name:Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Denis C. Shields
      affiliation:
            name:University College Dublin
            address:
               name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
            name:University College Dublin
            address:
               name:School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
      name:Jeremy C. Simpson
      url:http://orcid.org/0000-0002-7956-7805
      affiliation:
            name:University College Dublin
            address:
               name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
            name:University College Dublin
            address:
               name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
      name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
      name:Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
      name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
      name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
      name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
      name:School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland
      name:Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan
      name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
      name:School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
      name:School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
      name:UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(169)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.38s.

LINK . SPRINGER . COM {}