We are analyzing https://link.springer.com/article/10.1007/s00418-014-1277-z.

Title:
Yip1B isoform is localized at ER–Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle | Histochemistry and Cell Biology
Description:
The mechanism of endoplasmic reticulum (ER)–Golgi complex (GC) traffic is conserved from yeast to higher animals, but the architectures and the dynamics of vesicles’ traffic between ER and GC vary across cell types and species. Skeletal muscle is a unique tissue in which ER and GC undergo a structural reorganization during differentiation that completely remodels the secretory pathway. In mature skeletal muscle, the ER is turned into sarcoplasmic reticulum, which is composed of junctional and longitudinal regions specialized, respectively, in calcium release and uptake during contraction. During skeletal muscle differentiation, GC acquires a particular fragmented organization as it appears as spots both at the nuclear poles and along the fibers. The ubiquitary-expressed Yip1A isoform has been proposed to be involved in anterograde trafficking from the ER exit sites to the cis-side of the GC and in ER and GC architecture organization. We investigated the role of Yip1 in skeletal muscle. Here we report that, following skeletal muscle development, the expression of the Yip1A decreases and is replaced by the muscle-specific Yip1B isoform. Confocal microscope analysis revealed that in adult skeletal muscle the Yip1B isoform is localized in the ER–Golgi intermediate and cis-Golgi compartments. Finally, skeletal muscle knockdown experiments in vitro and in vivo suggested that Yip1B is not involved in GC structure maintenance.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

article, pubmed, google, scholar, cas, golgi, muscle, skeletal, cell, reticulum, complex, endoplasmic, biol, central, intermediate, access, protein, privacy, cookies, content, yipb, isoform, cisgolgi, structure, barone, sorrentino, sarcoplasmic, yipa, sites, ralston, information, publish, search, ergolgi, maintenance, september, mazzoli, vincenzo, involved, exit, membrane, apparatus, author, data, log, journal, research, localized, compartments, required,

Topics {✒️}

serena tronnolone & vincenzo sorrentino month download article/chapter pre-golgi intermediate compartment copi-independent retrograde transport endoplasmic reticulum-derived vesicles golgi membrane protein cis-golgi matrix proteins membrane protein enriched vincenzo sorrentino muscle-specific yip1b isoform related subjects ubiquitary-expressed yip1a isoform full article pdf mature skeletal muscle skeletal muscle development adult skeletal muscle privacy choices/manage cookies author information authors mammalian endoplasmic reticulum skeletal muscle differentiation skeletal muscle fibers endoplasmic reticulum structure dr jaakko saraste check access instant access cis-golgi compartments pre-golgi vacuoles er–golgi intermediate golgi complex reorganization cell biology aims transport gtpases ypt1p er exit sites article histochemistry sarcoplasmic reticulum skeletal muscle european economic area γ-sarcoglycan interactors fiber type-dependent microtubule organizing centers normal microtubule tracks telethon grant ggp13213 anti-p58 antibody article barone golgi apparatus remains conditions privacy policy yip1p–yif1p complex longitudinal regions specialized author correspondence article log endoplasmic reticulum

Questions {❓}

Zaal KJ, Reid E, Mousavi K, Zhang T, Mehta A, Bugnard E, Sartorelli V, Ralston E (2011) Who needs microtubules?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Yip1B isoform is localized at ER–Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle
         description:The mechanism of endoplasmic reticulum (ER)–Golgi complex (GC) traffic is conserved from yeast to higher animals, but the architectures and the dynamics of vesicles’ traffic between ER and GC vary across cell types and species. Skeletal muscle is a unique tissue in which ER and GC undergo a structural reorganization during differentiation that completely remodels the secretory pathway. In mature skeletal muscle, the ER is turned into sarcoplasmic reticulum, which is composed of junctional and longitudinal regions specialized, respectively, in calcium release and uptake during contraction. During skeletal muscle differentiation, GC acquires a particular fragmented organization as it appears as spots both at the nuclear poles and along the fibers. The ubiquitary-expressed Yip1A isoform has been proposed to be involved in anterograde trafficking from the ER exit sites to the cis-side of the GC and in ER and GC architecture organization. We investigated the role of Yip1 in skeletal muscle. Here we report that, following skeletal muscle development, the expression of the Yip1A decreases and is replaced by the muscle-specific Yip1B isoform. Confocal microscope analysis revealed that in adult skeletal muscle the Yip1B isoform is localized in the ER–Golgi intermediate and cis-Golgi compartments. Finally, skeletal muscle knockdown experiments in vitro and in vivo suggested that Yip1B is not involved in GC structure maintenance.
         datePublished:2014-09-11T00:00:00Z
         dateModified:2014-09-11T00:00:00Z
         pageStart:235
         pageEnd:243
         sameAs:https://doi.org/10.1007/s00418-014-1277-z
         keywords:
            Finger protein
            Yip
            Sarcoplasmic reticulum
            Skeletal muscle
            Golgi complex
            Biomedicine
            general
            Cell Biology
            Biochemistry
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig6_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig7_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig8_HTML.gif
         isPartOf:
            name:Histochemistry and Cell Biology
            issn:
               1432-119X
               0948-6143
            volumeNumber:143
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Virginia Barone
               affiliation:
                     name:University of Siena
                     address:
                        name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Elisa Mazzoli
               affiliation:
                     name:University of Siena
                     address:
                        name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jelena Kunic
               affiliation:
                     name:University of Siena
                     address:
                        name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniela Rossi
               affiliation:
                     name:University of Siena
                     address:
                        name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Serena Tronnolone
               affiliation:
                     name:University of Siena
                     address:
                        name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vincenzo Sorrentino
               affiliation:
                     name:University of Siena
                     address:
                        name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Yip1B isoform is localized at ER–Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle
      description:The mechanism of endoplasmic reticulum (ER)–Golgi complex (GC) traffic is conserved from yeast to higher animals, but the architectures and the dynamics of vesicles’ traffic between ER and GC vary across cell types and species. Skeletal muscle is a unique tissue in which ER and GC undergo a structural reorganization during differentiation that completely remodels the secretory pathway. In mature skeletal muscle, the ER is turned into sarcoplasmic reticulum, which is composed of junctional and longitudinal regions specialized, respectively, in calcium release and uptake during contraction. During skeletal muscle differentiation, GC acquires a particular fragmented organization as it appears as spots both at the nuclear poles and along the fibers. The ubiquitary-expressed Yip1A isoform has been proposed to be involved in anterograde trafficking from the ER exit sites to the cis-side of the GC and in ER and GC architecture organization. We investigated the role of Yip1 in skeletal muscle. Here we report that, following skeletal muscle development, the expression of the Yip1A decreases and is replaced by the muscle-specific Yip1B isoform. Confocal microscope analysis revealed that in adult skeletal muscle the Yip1B isoform is localized in the ER–Golgi intermediate and cis-Golgi compartments. Finally, skeletal muscle knockdown experiments in vitro and in vivo suggested that Yip1B is not involved in GC structure maintenance.
      datePublished:2014-09-11T00:00:00Z
      dateModified:2014-09-11T00:00:00Z
      pageStart:235
      pageEnd:243
      sameAs:https://doi.org/10.1007/s00418-014-1277-z
      keywords:
         Finger protein
         Yip
         Sarcoplasmic reticulum
         Skeletal muscle
         Golgi complex
         Biomedicine
         general
         Cell Biology
         Biochemistry
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig6_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig7_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-014-1277-z/MediaObjects/418_2014_1277_Fig8_HTML.gif
      isPartOf:
         name:Histochemistry and Cell Biology
         issn:
            1432-119X
            0948-6143
         volumeNumber:143
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Virginia Barone
            affiliation:
                  name:University of Siena
                  address:
                     name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Elisa Mazzoli
            affiliation:
                  name:University of Siena
                  address:
                     name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jelena Kunic
            affiliation:
                  name:University of Siena
                  address:
                     name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniela Rossi
            affiliation:
                  name:University of Siena
                  address:
                     name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Serena Tronnolone
            affiliation:
                  name:University of Siena
                  address:
                     name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vincenzo Sorrentino
            affiliation:
                  name:University of Siena
                  address:
                     name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Histochemistry and Cell Biology
      issn:
         1432-119X
         0948-6143
      volumeNumber:143
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Siena
      address:
         name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
         type:PostalAddress
      name:University of Siena
      address:
         name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
         type:PostalAddress
      name:University of Siena
      address:
         name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
         type:PostalAddress
      name:University of Siena
      address:
         name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
         type:PostalAddress
      name:University of Siena
      address:
         name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
         type:PostalAddress
      name:University of Siena
      address:
         name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Virginia Barone
      affiliation:
            name:University of Siena
            address:
               name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
               type:PostalAddress
            type:Organization
      name:Elisa Mazzoli
      affiliation:
            name:University of Siena
            address:
               name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
               type:PostalAddress
            type:Organization
      name:Jelena Kunic
      affiliation:
            name:University of Siena
            address:
               name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
               type:PostalAddress
            type:Organization
      name:Daniela Rossi
      affiliation:
            name:University of Siena
            address:
               name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
               type:PostalAddress
            type:Organization
      name:Serena Tronnolone
      affiliation:
            name:University of Siena
            address:
               name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
               type:PostalAddress
            type:Organization
      name:Vincenzo Sorrentino
      affiliation:
            name:University of Siena
            address:
               name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
      name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
      name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
      name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
      name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
      name:Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(105)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.95s.

LINK . SPRINGER . COM {}