We are analyzing https://link.springer.com/article/10.1007/s00418-012-0969-5.

Title:
Evidence for a partial epithelial–mesenchymal transition in postnatal stages of rat auditory organ morphogenesis | Histochemistry and Cell Biology
Description:
The epithelial–mesenchymal transition (EMT) plays a crucial role in the differentiation of many tissues and organs. So far, an EMT was not detected in the development of the auditory organ. To determine whether an EMT may play a role in the morphogenesis of the auditory organ, we studied the spatial localization of several EMT markers, the cell–cell adhesion molecules and intermediate filament cytoskeletal proteins, in epithelium of the dorsal cochlea during development of the rat Corti organ from E18 (18th embryonic day) until P25 (25th postnatal day). We examined by confocal microscopy immunolabelings on cryosections of whole cochleae with antibodies anti-cytokeratins as well as with antibodies anti-vimentin, anti-E-cadherin and anti-β-catenin. Our results showed a partial loss of E-cadherin and β-catenin and a temporary appearance of vimentin in pillar cells and Deiters between P8 and P10. These observations suggest that a partial EMT might be involved in the remodelling of the Corti organ during the postnatal stages of development in rat.
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Keywords {🔍}

article, google, scholar, pubmed, cas, cell, organ, cells, rat, corti, development, epithelialmesenchymal, transition, expression, emt, intermediate, cochlea, res, access, lane, journal, postnatal, proteins, vimentin, filaments, privacy, cookies, content, data, morphogenesis, nicolas, antibodies, ramaekers, fcs, biol, epithelial, information, publish, search, partial, auditory, johnen, thelen, cytoskeletal, ecadherin, pillar, hair, open, cytokeratin, clin,

Topics {✒️}

marie cloes & marc thiry month download article/chapter developmental stage-dependent pattern anti-myosin vi antibody cell–cell adhesion molecules partial epithelial–mesenchymal transition full article pdf related subjects privacy choices/manage cookies epithelial–mesenchymal transition epithelial-mesenchymal transition epithelial-mesenchymal transitions marie-emilie francart corti development access freshly isolated cochlea keratin filament deployment outer hair cell 25th postnatal day semicircular canal morphogenesis adult human cochlea european economic area 18th embryonic day confocal microscopy immunolabelings laryngo-rhino-otologie 69 developmentally-regulated coexpression author information authors electronic supplementary material cell biology aims hair cell receptors cancer cell invasion developing mammalian cochlea conditions privacy policy human hepatocellular carcinoma intermediate filament proteins article johnen early identification skilful technical assistance dr pierre leprince sl spiral limbus sv stria vascularis development [epub ahead rm reissner membrane article histochemistry anti-β-catenin accepting optional cookies monoclonal antibodies specific introducing intermediate filaments antibodies anti-cytokeratins anti-e-cadherin comparative expression patterns

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