We are analyzing https://link.springer.com/article/10.1007/s00418-008-0503-y.

Title:
Thy-1 is expressed in myofibroblasts but not found in hepatic stellate cells following liver injury | Histochemistry and Cell Biology
Description:
Thy-1 (CD90) is an adhesion molecule induced in fibroblast populations associated with wound healing and fibrosis. In this study the question whether Thy-1-gene-expression can be induced in hepatic stellate cells (HSC) in vivo, under conditions of liver injury or liver regeneration was addressed. Acute and chronic rat liver injury was induced by the administration of CCl4. For comparison, cirrhotic human liver, and rat 67% partial hepatectomy (PH) was studied as well. Thy-1-gene-expression was examined also in isolated human liver myofibroblasts. Thy-1-mRNA expression was significantly upregulated in chronic liver injury. Thy-1+ cells were detected in the periportal area of rat liver specimens in normal-, injured- and regenerative-conditions. In chronic human and rat liver injury, Thy-1+ cells were located predominantly in scar tissue. In the pericentral necrotic zone after CCl4-treatment, no induction of Thy-1 was found. Gremlin and Thy-1 showed comparable localization in the periportal areas. Thy-1 was not detected in either normal or capillarized sinusoids, in isolated rat HSC, and was neither inducible by inflammatory cytokines in isolated HSC, nor upregulated in treated myofibroblasts. Based upon these data Thy-1 is not a marker of “activated” sinusoidal HSC, but it is a marker of “activated” (myo)fibroblasts found in portal areas and in scar tissue.
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Keywords {🔍}

liver, thy, cells, rat, myofibroblasts, sma, expression, google, scholar, hepatic, cell, article, fig, human, injury, pubmed, cas, stellate, desmin, ramadori, hsc, portal, dudas, periportal, normal, saile, gremlin, isolated, acute, chronic, found, sinusoids, reaction, ccl, table, vivo, tissue, vitro, markers, knittel, regeneration, marker, germany, colocalization, analysis, original, fibroblasts, green, increased, full,

Topics {✒️}

a-smooth muscle-actin isoform real-time rt-pcr hepatocyte growth factor/hepatopoietin gpi-anchored proteins p38 map kinase real-time pcr analysis georg-august-university göttingen isotype-matching mouse igg utilizing northern blot-analysis full size image interferon-gamma acts proapoptotic tgf-β1 dependent pathway spontaneous fas-mediated apoptosis danko batusic & giuliano ramadori cd95/cd95l-mediated apoptosis stellate cell-enriched fraction increased rho-gtpase activity ccl4/corn oil solution article download pdf vitamin a-free cells isotype-specific control immunoglobulins threshold pcr cycle-values signaling molecule regulated smooth muscle cells conventional qhsc-enriched fraction thy-1-immunhistochemical reaction increased hepatic stellate cell open access sequentially repeated ccl4-administration sma pcr-product quantities single ccl4-treated rats hepatic stellate cells sma-gene-expression decreases cell-rich stroma adjacent stable hepatocyte marker corn oil-treated controls induce myofibroblast migration privacy choices/manage cookies cell surface glycoprotein sparse periportal thy-1-expression thy-1-positive cells detected von willebrand-factor full access chronic liver injury rho gtpase activity related subjects rat liver injury vascular endothelial cells liver mesenchymal cells scar–parenchymal interface

Questions {❓}

Ramadori G, Saile B (2002) Mesenchymal cells in the liver-one cell type or two?

Schema {🗺️}

WebPage:
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         headline:Thy-1 is expressed in myofibroblasts but not found in hepatic stellate cells following liver injury
         description:Thy-1 (CD90) is an adhesion molecule induced in fibroblast populations associated with wound healing and fibrosis. In this study the question whether Thy-1-gene-expression can be induced in hepatic stellate cells (HSC) in vivo, under conditions of liver injury or liver regeneration was addressed. Acute and chronic rat liver injury was induced by the administration of CCl4. For comparison, cirrhotic human liver, and rat 67% partial hepatectomy (PH) was studied as well. Thy-1-gene-expression was examined also in isolated human liver myofibroblasts. Thy-1-mRNA expression was significantly upregulated in chronic liver injury. Thy-1+ cells were detected in the periportal area of rat liver specimens in normal-, injured- and regenerative-conditions. In chronic human and rat liver injury, Thy-1+ cells were located predominantly in scar tissue. In the pericentral necrotic zone after CCl4-treatment, no induction of Thy-1 was found. Gremlin and Thy-1 showed comparable localization in the periportal areas. Thy-1 was not detected in either normal or capillarized sinusoids, in isolated rat HSC, and was neither inducible by inflammatory cytokines in isolated HSC, nor upregulated in treated myofibroblasts. Based upon these data Thy-1 is not a marker of “activated” sinusoidal HSC, but it is a marker of “activated” (myo)fibroblasts found in portal areas and in scar tissue.
         datePublished:2008-09-17T00:00:00Z
         dateModified:2008-09-17T00:00:00Z
         pageStart:115
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            Rho-GTP-ases
            Myofibroblasts invasivity
            GPI-anchored proteins
            Lipid raft
            Biomedicine
            general
            Cell Biology
            Biochemistry
            Developmental Biology
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ScholarlyArticle:
      headline:Thy-1 is expressed in myofibroblasts but not found in hepatic stellate cells following liver injury
      description:Thy-1 (CD90) is an adhesion molecule induced in fibroblast populations associated with wound healing and fibrosis. In this study the question whether Thy-1-gene-expression can be induced in hepatic stellate cells (HSC) in vivo, under conditions of liver injury or liver regeneration was addressed. Acute and chronic rat liver injury was induced by the administration of CCl4. For comparison, cirrhotic human liver, and rat 67% partial hepatectomy (PH) was studied as well. Thy-1-gene-expression was examined also in isolated human liver myofibroblasts. Thy-1-mRNA expression was significantly upregulated in chronic liver injury. Thy-1+ cells were detected in the periportal area of rat liver specimens in normal-, injured- and regenerative-conditions. In chronic human and rat liver injury, Thy-1+ cells were located predominantly in scar tissue. In the pericentral necrotic zone after CCl4-treatment, no induction of Thy-1 was found. Gremlin and Thy-1 showed comparable localization in the periportal areas. Thy-1 was not detected in either normal or capillarized sinusoids, in isolated rat HSC, and was neither inducible by inflammatory cytokines in isolated HSC, nor upregulated in treated myofibroblasts. Based upon these data Thy-1 is not a marker of “activated” sinusoidal HSC, but it is a marker of “activated” (myo)fibroblasts found in portal areas and in scar tissue.
      datePublished:2008-09-17T00:00:00Z
      dateModified:2008-09-17T00:00:00Z
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      pageEnd:127
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         Hepatic stellate cells
         Rho-GTP-ases
         Myofibroblasts invasivity
         GPI-anchored proteins
         Lipid raft
         Biomedicine
         general
         Cell Biology
         Biochemistry
         Developmental Biology
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      name:Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg-August-University Göttingen, Göttingen, Germany
      name:Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg-August-University Göttingen, Göttingen, Germany

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