We are analyzing https://link.springer.com/article/10.1007/s00418-008-0452-5.

Title:
The renal cortical interstitium: morphological and functional aspects | Histochemistry and Cell Biology
Description:
The renal interstitial compartment, situated between basement membranes of epithelia and vessels, contains two contiguous cellular networks. One network is formed by interstitial fibroblasts, the second one by dendritic cells. Both are in intimate contact with each other. Fibroblasts are interconnected by junctions and connected to basement membranes of vessels and tubules by focal adhesions. Fibroblasts constitute the “skeleton” of the kidney. In the renal cortex, fibroblasts produce erythropoietin and are distinguished from other interstitial cells by their prominent F-actin cytoskeleton, abundance of rough endoplasmic reticulum, and by ecto-5′-nucleotidase expression in their plasma membrane. The resident dendritic cells belong to the mononuclear phagocyte system and fulfil a sentinel function. They are characterized by their expression of MHC class II and CD11c. The central situation of fibroblasts suggests that signals from tubules, vessels, and inflammatory cells converge in fibroblasts and elicit an integrated response. Following tubular damage and inflammatory signals fibroblasts proliferate, change to the myofibroblast phenotype and increase their collagen production, potentially resulting in renal fibrosis. The acquisition of a profibrotic phenotype by fibroblasts in renal diseases is generally considered a main causal event in the progression of chronic renal failure. However, it might also be seen as a repair process.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

fibroblasts, cells, renal, google, scholar, pubmed, kidney, article, cas, interstitial, cell, dendritic, fig, processes, interstitium, myofibroblasts, fibroblast, cortical, hir, αsma, tubular, kaissling, fibrosis, healthy, rat, tubules, expression, peritubular, erythropoietin, tissue, int, membrane, size, full, image, kidneys, nephrol, cellular, cortex, epithelial, electron, protein, plasma, production, rer, function, basement, maxwell, ectonucleotidase, adenosine,

Topics {✒️}

s100a4/fsp1-positive cells increases homologously recombined erythopoietin-sv40 glycosyl-phosphatidylinositol-anchored protein bone marrow-derived cells rat calcium-binding protein f-actin filaments beneath article download pdf ecto-5′-nucleotidase/cd73-deficient mice full size image prominent f-actin cytoskeleton sgc-cgmp signalling pathway cytosolic protein s100a4/fsp1 unilateral ureter obstruction abundant f-actin filaments unilateral ureteral obstruction renal erythropoietin-producing cells prominent f-actin skeleton erythropoietin-producing cells show anti-thy-1 nephritis 5′nt-positive fibroblasts increases calcium-binding protein αsma-positive interstitial cells 5′nt-positive renal fibroblasts interstitial αsma-positive fibroblast aa afferent arteriole f-actin stress fibers membrane-bound ecto-5′-nucleotidase acute renal failure 5′nt-positive peritubular fibroblasts ecto-5′-nucleotidase-expressing processes uranyl acetate resulted privacy choices/manage cookies smooth muscle cells occasionally cd73-positive lymphocytes intermediate filament protein de-novo expression fibroblast growth factor-1 thin cytoplasmic rim mhc class ii f-actin filaments chronic renal failure diseased kidney s100a4/fsp1 tubules remained αsma-negative chonic renal failure rough endoplasmic reticulum full access actin filaments immediately van kooten tg erythropoietin producing cells broad cytoplasmic rim

Questions {❓}

Eddy AA (2005) Can renal fibrosis be reversed?
Fibrosis and nephron loss: which comes first?
Mazzucchelli L (2002) Protein S100A4: too long overlooked by pathologists?

Schema {🗺️}

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         datePublished:2008-06-25T00:00:00Z
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      headline:The renal cortical interstitium: morphological and functional aspects
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         Biochemistry
         Developmental Biology
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