We are analyzing https://link.springer.com/article/10.1007/s00418-005-0051-7.

Title:
E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia | Histochemistry and Cell Biology
Description:
E-cadherin is a cell–cell adhesion protein expressed in cytotrophoblasts, which is lost as they differentiate and syncytialise. We have exploited E-cadherin as a marker of cytotrophoblasts to investigate villous tissue composition in first and third trimester placentae, both in normal pregnancy and pregnancies complicated by pre-eclampsia. We have achieved this by measuring expression levels of E-cadherin at the mRNA level, using Q-PCR, and at the protein level using semi-quantitative Western blotting. We have also combined E-cadherin immunohistochemistry with morphometric analysis of area measurements to define cytotrophoblast and syncytiotrophoblast compartments. This novel use of E-cadherin has revealed a decrease in the proportion of cytotrophoblasts in villous tissue as pregnancy progresses, in the absence of changes in syncytiotrophoblast cover. Moreover, in pre-eclampsia, placental E-cadherin was raised compared to syncytiotrophoblast, suggesting either exaggerated cytotrophoblast proliferation or impaired cytotrophoblast differentiation, both alterations of potential pathogenic importance.
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Keywords {🔍}

article, google, scholar, pubmed, cas, human, placenta, preeclampsia, placental, ecadherin, cell, complicated, trophoblast, cytotrophoblast, baker, villous, pregnancy, expression, pregnancies, crocker, cytotrophoblasts, gynecol, privacy, cookies, content, access, apoptosis, development, growth, biol, huppertz, kingdom, kaufmann, mayhew, publish, search, turnover, lacey, protein, syncytiotrophoblast, differentiation, cells, term, apoptotic, intrauterine, histochem, obstet, analysis, data, information,

Topics {✒️}

month download article/chapter c-erbb-2 oncogene product combined e-cadherin immunohistochemistry semi-quantitative western blotting cell adhesion molecules epithelial transition full article pdf cell biology aims human epithelial cells privacy choices/manage cookies related subjects mayhew tm e-cadherin expression exploited e-cadherin placental e-cadherin beta-catenin mrna epithelial proliferative units human placental villi human placenta grows keith jc jr trophoblast cell fusion scope submit manuscript potential pathogenic importance strauss jf iii laoag-fernandez jb placental villous tree hypoxia alters expression real-time qpcr sixth annual report �reference trap’ revisited describe fetoplacental angiogenesis simpson ra human placental morphogenesis article histochemistry intrauterine growth restriction intrauterine growth retardation �classical” cadherin family conditions privacy policy european economic area measuring expression levels pre-eclampsia image analysis technique impaired trophoblast syncytialisation trophoblast-endometrium interactions accepting optional cookies exaggerated cytotrophoblast proliferation villous cytotrophoblast regulation syncytial apoptotic cascade small intestinal crypts classical cadherins

Questions {❓}

MacCalman CD, Furth EE, Omigbodun A, Bronner M, Coutifaris C, Strauss JF III (1996) Regulated expression of cadherin-11 in human epithelial cells: a role for cadherin-11 in trophoblast-endometrium interactions?

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