We are analyzing https://link.springer.com/article/10.1007/s00418-003-0585-5.

Title:
Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces | Histochemistry and Cell Biology
Description:
Stabilin-2, the hepatic hyaluronan receptor, has recently been cloned by us. Together with stabilin-1, stabilin-2 constitutes a novel family of fasciclin-like hyaluronan receptor homologues. Here, we analyzed expression of stabilin-2 (mStab-2) in a broad array of C57BL/6 mouse organs and tissues. While northern blot analysis showed positive expression of mStab-2 mRNA confined to liver and spleen, immunohistochemistry demonstrated mStab-2 protein expression in the endothelial sinuses of liver, lymph nodes, spleen, and bone marrow, and in specialized structures of eye, heart, brain, and kidney. Expression of mStab-2 was detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae. In pathological conditions, such as tumor growth or wound healing processes, mStab-2 was not expressed in the newly formed vasculature or other tissue components. Based on these results, we suggest that mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses. At the other mStab-2-positive tissues sites that are either avascular and/or demarcate a solid/liquid interface, mStab-2 may serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

google, scholar, pubmed, cas, hyaluronan, article, cells, laurent, endothelial, biol, fraser, cell, expression, stabilin, receptor, liver, mstab, kidney, tissue, access, morphogenesis, res, content, mouse, renal, development, human, smedsrød, hyaluronic, acid, biochem, privacy, cookies, protein, sinusoidal, tissues, schledzewski, goerdt, eye, rat, exp, pertoft, degradation, publish, search, fasciclinlike, hansen, lens, wound, circulation,

Topics {✒️}

ms-1 high-molecular-weight protein month download article/chapter berit hansen & sergij goerdt versican-rich pericellular matrix high-molecular-weight hyaluronan early-response gene signalling udp-glucose dehydrogenase required related subjects mstab-2-positive tissues sites solid/liquid interfaces full article pdf privacy choices/manage cookies hepatic hyaluronan receptor solid/liquid interface rat renomedullary interstitium lens epithelial cells sinusoidal endothelial cells wound healing processes dendritic cells/macrophages ureteric bud cells check access instant access murine sinusoidal endothelia cardiac valve formation ruprecht-karls-university liver endothelial cells article histochemistry c57bl/6 mouse organs ependymal cells lining cell biology aims epithelial-mesenchymal transition article falkowski hyaluronan receptor protein hyaluronan promotes lens vesicle morphogenesis european economic area newly formed vasculature distinct microvascular compartments primary biliary cirrhosis mechano-osmotic transducer mccourt pa theodor-kutzer-ufer 1-3 body autoradiographic study rejected human kidneys ductal branching morphogenesis renal water handling developing mouse heart maintain tissue integrity conditions privacy policy hyaluronan-mediated transformation

Questions {❓}

Petrides PE, Dittmann KH (1990) How do normal and leukemic white blood cells egress from the bone marrow?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces
         description:Stabilin-2, the hepatic hyaluronan receptor, has recently been cloned by us. Together with stabilin-1, stabilin-2 constitutes a novel family of fasciclin-like hyaluronan receptor homologues. Here, we analyzed expression of stabilin-2 (mStab-2) in a broad array of C57BL/6 mouse organs and tissues. While northern blot analysis showed positive expression of mStab-2 mRNA confined to liver and spleen, immunohistochemistry demonstrated mStab-2 protein expression in the endothelial sinuses of liver, lymph nodes, spleen, and bone marrow, and in specialized structures of eye, heart, brain, and kidney. Expression of mStab-2 was detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae. In pathological conditions, such as tumor growth or wound healing processes, mStab-2 was not expressed in the newly formed vasculature or other tissue components. Based on these results, we suggest that mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses. At the other mStab-2-positive tissues sites that are either avascular and/or demarcate a solid/liquid interface, mStab-2 may serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan.
         datePublished:2003-11-04T00:00:00Z
         dateModified:2003-11-04T00:00:00Z
         pageStart:361
         pageEnd:369
         sameAs:https://doi.org/10.1007/s00418-003-0585-5
         keywords:
            Stabilin
            Hyaluronan
            Proteoglycans
            Endothelial sinuses
            Biomedicine
            general
            Cell Biology
            Biochemistry
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhb1.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhc2a-c.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhc3a-h.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhc4a-h.jpg
         isPartOf:
            name:Histochemistry and Cell Biology
            issn:
               1432-119X
               0948-6143
            volumeNumber:120
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Martin Falkowski
               affiliation:
                     name:Ruprecht-Karls-University of Heidelberg
                     address:
                        name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kai Schledzewski
               affiliation:
                     name:Ruprecht-Karls-University of Heidelberg
                     address:
                        name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Berit Hansen
               affiliation:
                     name:Ruprecht-Karls-University of Heidelberg
                     address:
                        name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sergij Goerdt
               affiliation:
                     name:Ruprecht-Karls-University of Heidelberg
                     address:
                        name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces
      description:Stabilin-2, the hepatic hyaluronan receptor, has recently been cloned by us. Together with stabilin-1, stabilin-2 constitutes a novel family of fasciclin-like hyaluronan receptor homologues. Here, we analyzed expression of stabilin-2 (mStab-2) in a broad array of C57BL/6 mouse organs and tissues. While northern blot analysis showed positive expression of mStab-2 mRNA confined to liver and spleen, immunohistochemistry demonstrated mStab-2 protein expression in the endothelial sinuses of liver, lymph nodes, spleen, and bone marrow, and in specialized structures of eye, heart, brain, and kidney. Expression of mStab-2 was detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae. In pathological conditions, such as tumor growth or wound healing processes, mStab-2 was not expressed in the newly formed vasculature or other tissue components. Based on these results, we suggest that mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses. At the other mStab-2-positive tissues sites that are either avascular and/or demarcate a solid/liquid interface, mStab-2 may serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan.
      datePublished:2003-11-04T00:00:00Z
      dateModified:2003-11-04T00:00:00Z
      pageStart:361
      pageEnd:369
      sameAs:https://doi.org/10.1007/s00418-003-0585-5
      keywords:
         Stabilin
         Hyaluronan
         Proteoglycans
         Endothelial sinuses
         Biomedicine
         general
         Cell Biology
         Biochemistry
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhb1.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhc2a-c.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhc3a-h.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00418-003-0585-5/MediaObjects/s00418-003-0585-5fhc4a-h.jpg
      isPartOf:
         name:Histochemistry and Cell Biology
         issn:
            1432-119X
            0948-6143
         volumeNumber:120
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Martin Falkowski
            affiliation:
                  name:Ruprecht-Karls-University of Heidelberg
                  address:
                     name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kai Schledzewski
            affiliation:
                  name:Ruprecht-Karls-University of Heidelberg
                  address:
                     name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Berit Hansen
            affiliation:
                  name:Ruprecht-Karls-University of Heidelberg
                  address:
                     name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sergij Goerdt
            affiliation:
                  name:Ruprecht-Karls-University of Heidelberg
                  address:
                     name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Histochemistry and Cell Biology
      issn:
         1432-119X
         0948-6143
      volumeNumber:120
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Ruprecht-Karls-University of Heidelberg
      address:
         name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
         type:PostalAddress
      name:Ruprecht-Karls-University of Heidelberg
      address:
         name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
         type:PostalAddress
      name:Ruprecht-Karls-University of Heidelberg
      address:
         name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
         type:PostalAddress
      name:Ruprecht-Karls-University of Heidelberg
      address:
         name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Martin Falkowski
      affiliation:
            name:Ruprecht-Karls-University of Heidelberg
            address:
               name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
               type:PostalAddress
            type:Organization
      name:Kai Schledzewski
      affiliation:
            name:Ruprecht-Karls-University of Heidelberg
            address:
               name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Berit Hansen
      affiliation:
            name:Ruprecht-Karls-University of Heidelberg
            address:
               name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
               type:PostalAddress
            type:Organization
      name:Sergij Goerdt
      affiliation:
            name:Ruprecht-Karls-University of Heidelberg
            address:
               name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
      name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
      name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
      name:Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(155)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.97s.

LINK . SPRINGER . COM {}