We are analyzing https://link.springer.com/article/10.1007/s00415-022-11482-4.

Title:
Retina thickness in clinically affected and unaffected eyes in patients with aquaporin-4 immunoglobulin G antibody seropositive neuromyelitis optica spectrum disorders: a systematic review and meta-analysis | Journal of Neurology
Description:
Background and purpose Retina thickness has been studied in patients with neuromyelitis optica spectrum disorders (NMOSD) without distinguishing serostatus and limited data are available in unaffected eyes. We aimed to investigate retina thickness in eyes of aquaporin-4 immunoglobulin G antibody seropositive (AQP4-IgG+) NMOSD patients with optic neuritis (AQP4-ON) and without (AQP4-NON). Methods Eligible studies were identified by searching PubMed and Embase. Mean difference (MD, μm) with corresponding 95% confidence interval (CI) was pooled with random-effect models. The primary measures were average thickness of peripapillar retinal nerve fiber layer (pRNFL) centered on optic disc and the combination of ganglion cell layer and inner plexiform layer (GCIPL) at macula. Results We included 21 studies enrolling 787 AQP4-IgG+ NMOSD patients. Compared with healthy control, pRNFL was thinner in eyes of AQP4-ON (− 32.78, 95% CI [− 36.24, − 29.33]) and AQP4-NON (− 2.76, 95% CI [− 3.94, − 1.58]), so was GICPL in AQP4-ON (-21.38, 95% CI [− 24.01, − 18.74]) and AQP4-NON (95% CI − 2.96, [− 3.91, − 2.00]). Compared with multiple sclerosis with ON, AQP4-ON had thinner pRNFL (− 13.56, 95%CI [− 16.51, − 10.60]) and GCIPL (− 9.12, 95% CI [− 11.88, − 6.36]). AQP4-ON and myelin oligodendrocyte glycoprotein antibody-associated demyelination with ON (MOG-ON) had similar pRNFL (0.59, 95% CI [− 6.61, 7.79]) and GCIPL thickness (− 0.55, 95% CI [− 2.92, 1.82]). AQP4-NON had similar pRNFL and GCIPL thickness to MOG-NON and multiple sclerosis without ON. Conclusions The average thickness of pRNFL and GICPL decreased both in AQP4-ON and AQP4-NON eyes. AQP4-ON eyes had a similar level of pRNFL and GICPL thinning to MOG-ON eyes, so did AQP4-NON to MOG-NON eyes.
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article, google, scholar, neuromyelitis, optica, spectrum, optic, neurol, retinal, cas, patients, aquaporin, disorders, neuritis, eyes, disorder, antibody, systematic, layer, data, retina, thickness, seropositive, review, zhang, nerve, multiple, sclerosis, myelin, oligodendrocyte, glycoprotein, study, optical, coherence, tomography, metaanalysis, aqpon, prnfl, visual, content, huang, nmosd, aqpnon, related, oertel, privacy, cookies, journal, search, neurology,

Topics {✒️}

month download article/chapter aqp4-antibody-seropositive nmosd aqp4-igg seropositive nmosd optical coherence tomography rat passive-transfer model subclinical retinal atrophy nmo spectrum disorder aquaporin-4 igg seropositivity aqp4 seropositive nmosd ganglion cell layer retinal layer segmentation retinal vascular network myelin oligodendrocyte glycoprotein myelin-oligodendrocyte-glycoprotein privacy choices/manage cookies mog antibody disease optic nerve damage mammalian optic nerve retina microvascular density full article pdf antibody cross-linking meta-analysis review published related subjects antibody seropositive related disorders microstructural visual system investigate retina thickness mog-igg seropositivity china medical university neuromyelitis optica optic neuritis phenotypes severe optic neuritis aquaporin-4-binding autoantibodies holds exclusive rights systematic literature search european economic area distinguishing serostatus random-effect models preferred reporting items intrinsic pathogenic role complement activating antibodies detergent-insoluble fractions altered protein phosphorylation ethics declarations conflicts important intellectual content conditions privacy policy silent mri lesions yjw interpreted data müller glial dysfunction electronic supplementary material

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         description:Retina thickness has been studied in patients with neuromyelitis optica spectrum disorders (NMOSD) without distinguishing serostatus and limited data are available in unaffected eyes. We aimed to investigate retina thickness in eyes of aquaporin-4 immunoglobulin G antibody seropositive (AQP4-IgG+) NMOSD patients with optic neuritis (AQP4-ON) and without (AQP4-NON). Eligible studies were identified by searching PubMed and Embase. Mean difference (MD, μm) with corresponding 95% confidence interval (CI) was pooled with random-effect models. The primary measures were average thickness of peripapillar retinal nerve fiber layer (pRNFL) centered on optic disc and the combination of ganglion cell layer and inner plexiform layer (GCIPL) at macula. We included 21 studies enrolling 787 AQP4-IgG+ NMOSD patients. Compared with healthy control, pRNFL was thinner in eyes of AQP4-ON (− 32.78, 95% CI [− 36.24, − 29.33]) and AQP4-NON (− 2.76, 95% CI [− 3.94, − 1.58]), so was GICPL in AQP4-ON (-21.38, 95% CI [− 24.01, − 18.74]) and AQP4-NON (95% CI − 2.96, [− 3.91, − 2.00]). Compared with multiple sclerosis with ON, AQP4-ON had thinner pRNFL (− 13.56, 95%CI [− 16.51, − 10.60]) and GCIPL (− 9.12, 95% CI [− 11.88, − 6.36]). AQP4-ON and myelin oligodendrocyte glycoprotein antibody-associated demyelination with ON (MOG-ON) had similar pRNFL (0.59, 95% CI [− 6.61, 7.79]) and GCIPL thickness (− 0.55, 95% CI [− 2.92, 1.82]). AQP4-NON had similar pRNFL and GCIPL thickness to MOG-NON and multiple sclerosis without ON. The average thickness of pRNFL and GICPL decreased both in AQP4-ON and AQP4-NON eyes. AQP4-ON eyes had a similar level of pRNFL and GICPL thinning to MOG-ON eyes, so did AQP4-NON to MOG-NON eyes.
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      description:Retina thickness has been studied in patients with neuromyelitis optica spectrum disorders (NMOSD) without distinguishing serostatus and limited data are available in unaffected eyes. We aimed to investigate retina thickness in eyes of aquaporin-4 immunoglobulin G antibody seropositive (AQP4-IgG+) NMOSD patients with optic neuritis (AQP4-ON) and without (AQP4-NON). Eligible studies were identified by searching PubMed and Embase. Mean difference (MD, μm) with corresponding 95% confidence interval (CI) was pooled with random-effect models. The primary measures were average thickness of peripapillar retinal nerve fiber layer (pRNFL) centered on optic disc and the combination of ganglion cell layer and inner plexiform layer (GCIPL) at macula. We included 21 studies enrolling 787 AQP4-IgG+ NMOSD patients. Compared with healthy control, pRNFL was thinner in eyes of AQP4-ON (− 32.78, 95% CI [− 36.24, − 29.33]) and AQP4-NON (− 2.76, 95% CI [− 3.94, − 1.58]), so was GICPL in AQP4-ON (-21.38, 95% CI [− 24.01, − 18.74]) and AQP4-NON (95% CI − 2.96, [− 3.91, − 2.00]). Compared with multiple sclerosis with ON, AQP4-ON had thinner pRNFL (− 13.56, 95%CI [− 16.51, − 10.60]) and GCIPL (− 9.12, 95% CI [− 11.88, − 6.36]). AQP4-ON and myelin oligodendrocyte glycoprotein antibody-associated demyelination with ON (MOG-ON) had similar pRNFL (0.59, 95% CI [− 6.61, 7.79]) and GCIPL thickness (− 0.55, 95% CI [− 2.92, 1.82]). AQP4-NON had similar pRNFL and GCIPL thickness to MOG-NON and multiple sclerosis without ON. The average thickness of pRNFL and GICPL decreased both in AQP4-ON and AQP4-NON eyes. AQP4-ON eyes had a similar level of pRNFL and GICPL thinning to MOG-ON eyes, so did AQP4-NON to MOG-NON eyes.
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         Optical coherence tomography
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         Neurosciences
         Neuroradiology
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