We are analyzing https://link.springer.com/article/10.1007/s00415-015-7766-8.

Title:
Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75 | Journal of Neurology
Description:
Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this diagnosis initially seemed unlikely because of their age and age-associated concomitant diseases, and briefly review the literature. All three patients, aged 79, 82 and 88 years, presented with a spinal cord syndrome as the first clinical manifestation of AQP4-Ab-positive NMOSD. They all had severe relapses unless immunosuppressive therapy was initiated, and one untreated patient died of a fatal NMOSD course. Two patients developed side effects of immunosuppression. We conclude that a first manifestation of NMOSD should be considered even in patients beyond the age of 75 years with a compatible syndrome, especially longitudinally extensive myelitis. Early diagnosis and treatment are feasible and highly relevant. Special attention is warranted in the elderly to recognize adverse effects of immunosuppressive therapies as early as possible.
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Keywords {🔍}

university, neuromyelitis, optica, patients, article, nmosd, pubmed, google, scholar, research, years, nmo, lateonset, age, case, edss, mri, neurology, disease, patient, received, cas, neurol, myelitis, treatment, aqpab, germany, lesions, csf, myelon, consent, spectrum, onset, clinical, normal, novartis, diagnosis, multiple, sclerosis, positive, study, klinik, berlin, analysis, paul, initially, spinal, died, extensive, antibodies,

Topics {✒️}

de/medizin/ethikkommission/antragstellung/index received travel/accommodations/meeting expenses ulrich hofstadt-van oy late-onset multiple sclerosis recombinant cell-based assays visual evoked potentials article download pdf thiopurine s-methyltransferase activity central gadolinium enhancement developed anti-platelet antibodies late-onset neuromyelitis optica long-term prophylactic treatment cell-based immunofluorescence assay serum aqp4-ab testing grete buchholz serum aqp4-ab turned isolated optic neuritis spinal cord syndrome severe optic neuritis severe autoimmune disease contrasting disease patterns krankenhaus martha-maria halle concomitant diseases hofstadt-van oy aqp4-ab-positive nmosd aqp4-ab positive nmosd privacy choices/manage cookies nmo spectrum disorders table 1 screening pubmed normal cell count seronegative neuromyelitis optica spinal mri demonstrated asklepios klinik teupitz magnetic resonance imaging longitudinally extensive myelitis heinrich-heine-university düsseldorf dorsal gadolinium enhancement received travel expenses wingerchuk dm high-graded paraparesis low amplitudes bilaterally multiple sclerosis facs-based assay csf-restricted band partially gadolinium-enhancing including complete nmo author information authors nordwest-krankenhaus sanderbusch article krumbholz shown inflammatory lesions

Questions {❓}

Bourre B, Lefaucheur R, Girault C (2013) Treatment of NMO relapse in the elderly: rituximab when plasma exchange fails?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75
         description:Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this diagnosis initially seemed unlikely because of their age and age-associated concomitant diseases, and briefly review the literature. All three patients, aged 79, 82 and 88 years, presented with a spinal cord syndrome as the first clinical manifestation of AQP4-Ab-positive NMOSD. They all had severe relapses unless immunosuppressive therapy was initiated, and one untreated patient died of a fatal NMOSD course. Two patients developed side effects of immunosuppression. We conclude that a first manifestation of NMOSD should be considered even in patients beyond the age of 75 years with a compatible syndrome, especially longitudinally extensive myelitis. Early diagnosis and treatment are feasible and highly relevant. Special attention is warranted in the elderly to recognize adverse effects of immunosuppressive therapies as early as possible.
         datePublished:2015-05-10T00:00:00Z
         dateModified:2015-05-10T00:00:00Z
         pageStart:1379
         pageEnd:1384
         sameAs:https://doi.org/10.1007/s00415-015-7766-8
         keywords:
            Neuromyelitis optica (Devic syndrome)
            Myelitis
            Aquaporin 4 antibodies
            Very late-onset
            Elderly/old-age
            Therapy/immunosuppression
            Neurology
            Neurosciences
            Neuroradiology
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               type:Person
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                        type:PostalAddress
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                        type:PostalAddress
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               type:Person
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ScholarlyArticle:
      headline:Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75
      description:Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this diagnosis initially seemed unlikely because of their age and age-associated concomitant diseases, and briefly review the literature. All three patients, aged 79, 82 and 88 years, presented with a spinal cord syndrome as the first clinical manifestation of AQP4-Ab-positive NMOSD. They all had severe relapses unless immunosuppressive therapy was initiated, and one untreated patient died of a fatal NMOSD course. Two patients developed side effects of immunosuppression. We conclude that a first manifestation of NMOSD should be considered even in patients beyond the age of 75 years with a compatible syndrome, especially longitudinally extensive myelitis. Early diagnosis and treatment are feasible and highly relevant. Special attention is warranted in the elderly to recognize adverse effects of immunosuppressive therapies as early as possible.
      datePublished:2015-05-10T00:00:00Z
      dateModified:2015-05-10T00:00:00Z
      pageStart:1379
      pageEnd:1384
      sameAs:https://doi.org/10.1007/s00415-015-7766-8
      keywords:
         Neuromyelitis optica (Devic syndrome)
         Myelitis
         Aquaporin 4 antibodies
         Very late-onset
         Elderly/old-age
         Therapy/immunosuppression
         Neurology
         Neurosciences
         Neuroradiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00415-015-7766-8/MediaObjects/415_2015_7766_Fig1_HTML.gif
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         issn:
            1432-1459
            0340-5354
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         name:Springer Berlin Heidelberg
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      author:
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            email:[email protected]
            type:Person
            name:Ulrich Hofstadt-van Oy
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            type:Person
            name:Klemens Angstwurm
            affiliation:
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                     name:Department of Neurology, University of Regensburg, Regensburg, Germany
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            type:Person
            name:Ingo Kleiter
            affiliation:
                  name:Ruhr-University
                  address:
                     name:Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany
                     type:PostalAddress
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            type:Person
            name:Sven Jarius
            affiliation:
                  name:University of Heidelberg
                  address:
                     name:Molecular Neuroimmunology Group, Dpt. of Neurology, University of Heidelberg, Heidelberg, Germany
                     type:PostalAddress
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            type:Person
            name:Friedemann Paul
            affiliation:
                  name:Charité University Medicine Berlin
                  address:
                     name:NeuroCure Clinical Research Center and Department of Neurology, Charité University Medicine Berlin, Berlin, Germany
                     type:PostalAddress
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            name:Orhan Aktas
            affiliation:
                  name:Medical Faculty, Heinrich Heine University
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            affiliation:
                  name:Asklepios Fachklinikum
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                     name:Klinik für Neurologie und Klinische Neurophysiologie, Asklepios Fachklinikum, Teupitz, Germany
                     type:PostalAddress
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            affiliation:
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                     name:Department of Neurology, Ludwig Maximilian University, Munich, Germany
                     type:PostalAddress
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         name:Department of Neurology, University of Regensburg, Regensburg, Germany
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         name:Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany
         type:PostalAddress
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         name:Molecular Neuroimmunology Group, Dpt. of Neurology, University of Heidelberg, Heidelberg, Germany
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         name:NeuroCure Clinical Research Center and Department of Neurology, Charité University Medicine Berlin, Berlin, Germany
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         name:Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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         name:Department of Neurology, Ludwig Maximilian University, Munich, Germany
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      email:[email protected]
      name:Ulrich Hofstadt-van Oy
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            name:Klinikum Bayreuth—Klinik Hohe Warte
            address:
               name:Klinik für Neurologie, Klinikum Bayreuth—Klinik Hohe Warte, Bayreuth, Germany
               type:PostalAddress
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      name:Klemens Angstwurm
      affiliation:
            name:University of Regensburg
            address:
               name:Department of Neurology, University of Regensburg, Regensburg, Germany
               type:PostalAddress
            type:Organization
      name:Ingo Kleiter
      affiliation:
            name:Ruhr-University
            address:
               name:Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany
               type:PostalAddress
            type:Organization
      name:Sven Jarius
      affiliation:
            name:University of Heidelberg
            address:
               name:Molecular Neuroimmunology Group, Dpt. of Neurology, University of Heidelberg, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Friedemann Paul
      affiliation:
            name:Charité University Medicine Berlin
            address:
               name:NeuroCure Clinical Research Center and Department of Neurology, Charité University Medicine Berlin, Berlin, Germany
               type:PostalAddress
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      name:Orhan Aktas
      affiliation:
            name:Medical Faculty, Heinrich Heine University
            address:
               name:Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
               type:PostalAddress
            type:Organization
      name:Grete Buchholz
      affiliation:
            name:Ludwig Maximilian University
            address:
               name:Department of Neurology, Ludwig Maximilian University, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Peter Kern
      affiliation:
            name:Asklepios Fachklinikum
            address:
               name:Klinik für Neurologie und Klinische Neurophysiologie, Asklepios Fachklinikum, Teupitz, Germany
               type:PostalAddress
            type:Organization
      name:Andreas Straube
      affiliation:
            name:Ludwig Maximilian University
            address:
               name:Department of Neurology, Ludwig Maximilian University, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Tania Kümpfel
      affiliation:
            name:Ludwig Maximilian University
            address:
               name:Institute of Clinical Neuroimmunology, Ludwig Maximilian University, Munich, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Clinical Neuroimmunology, Ludwig Maximilian University, Munich, Germany
      name:Klinik für Neurologie, Klinikum Bayreuth—Klinik Hohe Warte, Bayreuth, Germany
      name:Department of Neurology, University of Regensburg, Regensburg, Germany
      name:Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany
      name:Molecular Neuroimmunology Group, Dpt. of Neurology, University of Heidelberg, Heidelberg, Germany
      name:NeuroCure Clinical Research Center and Department of Neurology, Charité University Medicine Berlin, Berlin, Germany
      name:Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
      name:Department of Neurology, Ludwig Maximilian University, Munich, Germany
      name:Klinik für Neurologie und Klinische Neurophysiologie, Asklepios Fachklinikum, Teupitz, Germany
      name:Department of Neurology, Ludwig Maximilian University, Munich, Germany
      name:Institute of Clinical Neuroimmunology, Ludwig Maximilian University, Munich, Germany

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