We are analyzing https://link.springer.com/article/10.1007/s004120000095.

Title:
Distribution of gamma satellite DNA on the human X and Y chromosomes suggests that it is not required for mitotic centromere function | Chromosoma
Description:
The bulk of the DNA found at human centromeres is composed of tandemly arranged repeats, the most abundant of which is alpha satellite. Other human centromeric repetitive families have been identified, one of the more recent being gamma satellite. To date, gamma satellite DNAs have been reported at the centromeres of human chromosomes 8 and X. Here, we show that gamma-X satellite DNA is not interspersed with the major DZX1 alpha-X block, but rather is organised as a single array of approximately 40–50 kb on the short-arm side of the alpha satellite domain. This repeat array is absent on two mitotically stable Xq isochromosomes. Furthermore, a related repeat DNA has been identified on the human Y chromosome. Fluorescence in situ hybridisation has localised this satellite DNA to the long arm side of the major DYZ3 alpha-Y domain, outside the region previously defined as that required for mitotic centromere function. Together, these data suggest that while blocks of highly related gamma satellite DNAs are present in the pericentromeric regions of both human sex chromosomes, this repeated DNA is not required for mitotic centromere function.
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Keywords {🔍}

article, satellite, human, dna, function, access, privacy, cookies, content, gamma, chromosomes, mitotic, centromere, chromosome, data, information, publish, search, required, related, cambridge, log, journal, research, chromosoma, lee, critcher, zhang, centromeres, alpha, array, repeat, open, discover, springer, optional, personal, parties, policy, find, track, distribution, suggests, september, cite, mills, farr, explore, identified, dnas,

Topics {✒️}

month download article/chapter mitotic centromere function related repeat dna region previously defined repeat array gamma satellite dna human sex chromosomes privacy choices/manage cookies article chromosoma aims gamma satellite dnas alpha satellite domain full article pdf major dzx1 alpha major dyz3 alpha related subjects human centromeres pericentromeric regions alpha satellite european economic area scope submit manuscript tandemly arranged repeats short-arm side long arm side satellite dna conditions privacy policy complete human chromosome human chromosomes 8 check access instant access accepting optional cookies single array september 2000 volume 109 journal finder publish gamma satellite telomere assembly chromosomes suggests article log dna found repeated dna article lee centromeres article cite privacy policy human genome personal data books a optional cookies information manage preferences

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         headline:Distribution of gamma satellite DNA on the human X and Y chromosomes suggests that it is not required for mitotic centromere function
         description: The bulk of the DNA found at human centromeres is composed of tandemly arranged repeats, the most abundant of which is alpha satellite. Other human centromeric repetitive families have been identified, one of the more recent being gamma satellite. To date, gamma satellite DNAs have been reported at the centromeres of human chromosomes 8 and X. Here, we show that gamma-X satellite DNA is not interspersed with the major DZX1 alpha-X block, but rather is organised as a single array of approximately 40–50 kb on the short-arm side of the alpha satellite domain. This repeat array is absent on two mitotically stable Xq isochromosomes. Furthermore, a related repeat DNA has been identified on the human Y chromosome. Fluorescence in situ hybridisation has localised this satellite DNA to the long arm side of the major DYZ3 alpha-Y domain, outside the region previously defined as that required for mitotic centromere function. Together, these data suggest that while blocks of highly related gamma satellite DNAs are present in the pericentromeric regions of both human sex chromosomes, this repeated DNA is not required for mitotic centromere function.
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            Pericentromeric Region
            Alpha Satellite
            Repeat Array
            Centromere Function
            Cell Biology
            Developmental Biology
            Biochemistry
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            Human Genetics
            Animal Genetics and Genomics
            Eukaryotic Microbiology
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      headline:Distribution of gamma satellite DNA on the human X and Y chromosomes suggests that it is not required for mitotic centromere function
      description: The bulk of the DNA found at human centromeres is composed of tandemly arranged repeats, the most abundant of which is alpha satellite. Other human centromeric repetitive families have been identified, one of the more recent being gamma satellite. To date, gamma satellite DNAs have been reported at the centromeres of human chromosomes 8 and X. Here, we show that gamma-X satellite DNA is not interspersed with the major DZX1 alpha-X block, but rather is organised as a single array of approximately 40–50 kb on the short-arm side of the alpha satellite domain. This repeat array is absent on two mitotically stable Xq isochromosomes. Furthermore, a related repeat DNA has been identified on the human Y chromosome. Fluorescence in situ hybridisation has localised this satellite DNA to the long arm side of the major DYZ3 alpha-Y domain, outside the region previously defined as that required for mitotic centromere function. Together, these data suggest that while blocks of highly related gamma satellite DNAs are present in the pericentromeric regions of both human sex chromosomes, this repeated DNA is not required for mitotic centromere function.
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         Pericentromeric Region
         Alpha Satellite
         Repeat Array
         Centromere Function
         Cell Biology
         Developmental Biology
         Biochemistry
         general
         Human Genetics
         Animal Genetics and Genomics
         Eukaryotic Microbiology
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