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Title:
Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation | Chromosoma
Description:
The metazoan nucleus is disassembled and re-built at every mitotic cell division. The nuclear envelope, including nuclear pore complexes, breaks down at the beginning of mitosis to accommodate the capture of massively condensed chromosomes by the spindle apparatus. At the end of mitosis, a nuclear envelope is newly formed around each set of segregating and de-condensing chromatin. We review the current understanding of the membrane restructuring events involved in the formation of the nuclear membrane sheets of the envelope, the mechanisms governing nuclear pore complex assembly and integration in the nascent nuclear membranes, and the regulated coordination of these events with chromatin de-condensation.
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Keywords {🔍}
nuclear, google, scholar, pubmed, article, chromatin, cas, cell, membrane, assembly, proteins, npc, biol, pore, envelope, mitosis, mitotic, complex, nup, formation, membranes, postmitotic, recruitment, phosphorylation, interphase, npcs, nucleoporins, mol, inm, nucleus, fusion, end, events, protein, required, hetzer, antonin, sheets, organization, cells, fig, binding, histone, distinct, found, lbr, pom, insertion, sci, decondensation,
Topics {✒️}
dna-binding nucleoporin mel-28/elys full size image sun-kash nuclear-envelope bridges article download pdf post-mitotic chromatin de-condensation benjamin vollmer & wolfram antonin pore formation post-mitotically protein-free liposomes imply possess membrane-spanning domains cis-golgi vesicle trafficking montes de oca mel-28/elys-dependent recruitment exposing dna-binding domains post-translational histone modifications vaccinia-related kinases phosphorylate post-mitotic nuclear assembly nima-related kinase family post-mitotic nuclear formation post-mitotic npc assembly active npc-dependent import cdc48/p97 promotes reformation p34cdc2-type protein kinase post-mitotic de-phosphorylation surround post-mitotic chromatin post-mitotic npc formation outgrowing er-derived tubules cell cycle-dependent modifications chromatin-directed npc assembly post-mitotic assembly modes outgrowing er-derived membranes impact chromatin de-condensation nuclear envelope-specific membranes c-terminal-binding site protein-dna interactions involved post-mitotic ne assembly post-mitotic ne formation reticulon-positive membrane tubules importin beta regulates postmitotic nuclear envelope cell cycle-dependent binding cell cycle-dependent differences protein-protein interaction network elys recruits pom121 fluorescence imaging data ne-specific vesicles reflects snare-mediated membrane fusion post-mitotic chromatin structure cell cycle-dependent phosphorylation cell-cycle-dependent phosphorylation ne-specific lipid rafts
Questions {❓}
- Assuming that the predominance of mitotic ER sheets and tubules varies between cell types, the question becomes: What is the morphology of the ER that contacts chromatin and gives rise to the sheets of the NE?
- Maeshima K, Hihara S, Eltsov M (2010) Chromatin structure: does the 30-nm fibre exist in vivo?
- Weis K (2007) The nuclear pore complex: oily spaghetti or gummy bear?
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headline:Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation
description:The metazoan nucleus is disassembled and re-built at every mitotic cell division. The nuclear envelope, including nuclear pore complexes, breaks down at the beginning of mitosis to accommodate the capture of massively condensed chromosomes by the spindle apparatus. At the end of mitosis, a nuclear envelope is newly formed around each set of segregating and de-condensing chromatin. We review the current understanding of the membrane restructuring events involved in the formation of the nuclear membrane sheets of the envelope, the mechanisms governing nuclear pore complex assembly and integration in the nascent nuclear membranes, and the regulated coordination of these events with chromatin de-condensation.
datePublished:2012-10-27T00:00:00Z
dateModified:2012-10-27T00:00:00Z
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Nuclear envelope formation
Nuclear pore complex assembly
Chromatin decondensation
Mitotic exit
Cell Biology
Developmental Biology
Biochemistry
general
Human Genetics
Animal Genetics and Genomics
Eukaryotic Microbiology
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headline:Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation
description:The metazoan nucleus is disassembled and re-built at every mitotic cell division. The nuclear envelope, including nuclear pore complexes, breaks down at the beginning of mitosis to accommodate the capture of massively condensed chromosomes by the spindle apparatus. At the end of mitosis, a nuclear envelope is newly formed around each set of segregating and de-condensing chromatin. We review the current understanding of the membrane restructuring events involved in the formation of the nuclear membrane sheets of the envelope, the mechanisms governing nuclear pore complex assembly and integration in the nascent nuclear membranes, and the regulated coordination of these events with chromatin de-condensation.
datePublished:2012-10-27T00:00:00Z
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Nuclear envelope formation
Nuclear pore complex assembly
Chromatin decondensation
Mitotic exit
Cell Biology
Developmental Biology
Biochemistry
general
Human Genetics
Animal Genetics and Genomics
Eukaryotic Microbiology
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