We are analyzing https://link.springer.com/article/10.1007/s00403-013-1409-7.

Title:
Dapsone in dermatology and beyond | Archives of Dermatological Research
Description:
Dapsone (4,4′-diaminodiphenylsulfone) is an aniline derivative belonging to the group of synthetic sulfones. In 1937 against the background of sulfonamide era the microbial activity of dapsone has been discovered. Shortly thereafter, the use of dapsone to treat non-pathogen-caused diseases revealed alternate antiinflammatory mechanisms that initially were elucidated by inflammatory animal models. Thus, dapsone clearly has dual functions of both: antimicrobial/antiprotozoal effects and anti-inflammatory features similarly to non-steroidal anti-inflammatory drugs. The latter capabilities primarily were used in treating chronic inflammatory disorders. Dapsone has been investigated predominantly by in vitro methods aiming to get more insights into the effect of dapsone to inflammatory effector cells, cytokines, and/or mediators, such as cellular toxic oxygen metabolism, myoloperoxidase-/halogenid system, adhesion molecules, chemotaxis, membrane-associated phospholipids, prostaglandins, leukotrienes, interleukin-8, tumor necrosis factor α, lymphocyte functions, and tumor growth. Moreover, attention has been paid to mechanisms by which dapsone mediates effects in more complex settings like impact of lifespan, stroke, glioblastoma, or as anticonvulsive agent. Additionally, there are some dermatological investigations in human being using dapsone and its metabolites (e.g., leukotriene B4-induced chemotaxis, ultraviolet-induced erythema). It could be established that dapsone metabolites by their own have anti-inflammatory properties. Pharmacology and mechanisms of action are determining factors for clinical use of dapsone chiefly in neutrophilic and/or eosinophilic dermatoses and in chronic disorders outside the field of dermatology. The steroid-sparing effect of dapsone is useful for numerous clinical entities. Future avenues of investigations will provide more information on this fascinating and essential agent.
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Keywords {🔍}

dapsone, google, scholar, pubmed, cas, effect, patients, effects, dermatol, inhibition, human, therapy, treatment, cells, studies, pmn, production, concentrations, antiinflammatory, action, chemotaxis, results, diseases, inhibitory, fig, pharmacol, mechanisms, skin, table, clinical, ddsnoh, authors, clin, dermatology, full, therapeutic, drug, sulfone, acid, size, study, drugs, metabolites, influence, wozel, neutrophils, healthy, leprosy, data, activity,

Topics {✒️}

n-formyl-l-methionyl-l-leucyl-l-phenyalanine suppressed n-formyl-methionyl-leucyl-phenylalanine n-formyl-methionyl-leucyl-phenylalanine g6pd n-formyl-methionyl-leucyl-phenylalanine glucose-6-phosphate dehydrogenase-deficient glucose-6-phosphate dehydrogenase leukocyte-derived chemotactic factor 3 × 400 mg/day reduced met-hb-levels steroid-dependent neuro-sweet-disease steroid-dependent neuro-sweet disease ige-mediated antigen-stimulated production high-pressure liquid chromatography derivate des p-nitrothiophenols article download pdf ligand-receptor signal cascade fluorescence–activated cell sorter cum grano salis—equals /cm2 uva/philips tl09 complement-mediated guinea-pig reactions oxygen-radical scavenging ability pre-existing pulmonary kainate-induced striatal neurotoxicities full size image chemoatractant-induced signal transduction carrageenan-induced paw edema disease-dependent leucocyte alterations met-hb-inducing drugs pgh-pgd-isomerase step inducing met-hb production male swiss-webster mice xanthine/xanthine oxidase system phagocyte-mediated oxidative inactivation steroidal anti-inflammatory drugs sodium dodecylsulfate-induced erythema human alpha-1-protease inhibitor photo-patch tests revealed full size table modern molecular-targeted strategies developing molecular-based methods sulfilimine-based dapson analogs erythema elevatum diutinum—evidence double-blind comparative study uvb erythema-suppressing activity improved risk–benefit-ratio anti-cancer activity neutrophil myeloperoxidase-mediated iodination thrombocytopenic purpura related anti-inflammatory features similarly dapsone-induced optic atrophy arachidonic acid-induced mest

Questions {❓}

Grundmann SA, Kiefer S, Luger TA, Brehler R (2011) Delayed pressure urticaria—dapsone heading for first-line therapy?
Webster GF (2010) Is topical dapsone safe in glucose-6-phosphate dehydrogenase-deficient and sulfonamide-allergic patients?

Schema {🗺️}

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