We are analyzing https://link.springer.com/article/10.1007/s00403-004-0479-y.

Title:
Inhibition of melanoma metastases by fenofibrate | Archives of Dermatological Research
Description:
The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) α, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR α in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention.
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Keywords {🔍}

google, scholar, pubmed, cas, article, melanoma, cells, cancer, isi, peroxisome, cell, res, proliferatoractivated, receptor, fenofibrate, cholesterol, metastasis, research, growth, vitro, slominski, ppar, clin, oncol, university, privacy, cookies, content, inhibition, grabacka, effect, metastatic, bomirski, hamster, acid, receptors, membrane, nature, publish, search, maja, placha, pigmented, vivo, chemoprevention, access, aranega, gonzalez, effects, review,

Topics {✒️}

peroxisome proliferator-activated receptor-γ peroxisome proliferator-activated receptor hmg-coa reductase inhibitor month download article/chapter peroxisome proliferator-activated receptors western-blot analyses revealed octadecyl-2-o-methylglycero-3- phosphocholine bio-life sciences building cholesterol-negative feedback system full article pdf b16 tumor cells hamster melanoma variants van blittersvijk wj ppar γ ligands privacy choices/manage cookies receptor-4 signal transduction acute coronary events 9-cis retinoic acid metastatic tumor growth nongenotoxic peroxisome proliferators dermatological research aims molecular simulation study coronary heart disease polish state committee human melanoma cells aranega ae fibric acid derivatives statin-induced inhibition bomirski hamster melanoma human colon cancer glioblastoma cell invasion mammary carcinoma cells jeg3 choriocarcinoma cells lymphoma cells suggest article archives cholesterol-dependent clustering european economic area animals treated orally european clinical experience cxcr4 enhances adhesion single step method contemporary epidemiological trends antitumor agent phenylacetate von hoff dd anticancer therapeutic development brown–pierce carcinomas grants n-25/crbw-22/2001 n-25/crbw-vii-6/2002 health science center article grabacka

Questions {❓}

Dellavalle RP, Nicholas MK, Schilling LM (2003) Melanoma chemoprevention: a role for statins and fibrates?

Schema {🗺️}

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         description:The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) α, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR α in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention.
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