LINK . SPRINGER . COM {
}
Title:
bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status | Acta Neuropathologica
Description:
bcl-2 protein expression was characterized in a series of 58 astrocytomas from 21 pediatric and 37 adult patients. As part of a continuing attempt to define relevant prognostic factors which may predict clinical outcome, we have determined the impact of bcl-2 accumulation in malignant astrocytes on the length of patient survival. Aberrant overexpression of bcl-2 protein in tumor cells was detected in 57% (12 of 21) of pediatric and 73% (27 of 37) of the adult cases. Among pediatric patients, the median survival in months showed no relationship with the incidence of bcl-2-positive tumors. Among the adult patients, a favorable prognostic indicator was low-tumor grade (P = 0.05). bcl-2-positive tumors occurred with similar frequencies in WHO grades III and IV of malignancy. When bcl-2 expression in tumor cells was tested as a variable to predict for patient survival, the 6 patients without bcl-2 expression among 23 adult patients with grade IV tumors had a shorter median survival. The same 58 tumors had been previously analyzed for alterations of p53: 4 pediatric and 16 adult tumors had p53 gene mutations. There was no significant difference in median survival related to p53 gene status. There was no relationship between bcl-2 expression and p53 gene status: approximately equal numbers of tumors with either wild-type or mutant p53 were bcl-2 negative or bcl-2 positive. bcl-2 expression is high (40–100%) among other tumors of the central nervous system which also show low malignant potential. Up-regulation of bcl-2 in malignant astrocytes or constitutive expression in some tumor types may be a factor leading to a more favorable clinical outcome.
Website Age:
28 years and 1 months (reg. 1997-05-29).
Matching Content Categories {📚}
- Education
- Science
- TV
Content Management System {📝}
What CMS is link.springer.com built with?
Custom-built
No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of link.springer.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Link.springer.com Make Money? {💸}
We can't figure out the monetization strategy.
Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.
Keywords {🔍}
bcl, article, expression, survival, tumors, gene, patients, cancer, york, privacy, cookies, content, adult, access, usa, information, publish, research, search, protein, astrocytomas, patient, status, pediatric, prognostic, tumor, university, center, data, log, journal, acta, newcomb, bhalla, parrish, clinical, outcome, malignant, median, related, discover, springer, optional, analysis, personal, parties, policy, find, track, neuropathologica,
Topics {✒️}
month download article/chapter subtype-specific prognostic impact kaplan cancer center p53 gene status low-tumor grade bcl-2 protein expression bcl-2-positive tumors occurred p53 gene mutations full article pdf privacy choices/manage cookies favorable prognostic indicator cell cycle arrest median survival related favorable clinical outcome bcl-2 negative shorter median survival european economic area scope submit manuscript approximately equal numbers central nervous system cancer her2-positive conditions privacy policy predict clinical outcome check access instant access related subjects bcl-2 protein bcl-2-positive tumors accepting optional cookies bcl-2 expression article log journal finder publish acta neuropathol 94 grade iv tumors article newcomb article cite constitutive expression tumor cells tumor types median survival bcl-2 positive mutant p53 staten island privacy policy personal data york university patient survival high miller department
Schema {🗺️}
WebPage:
mainEntity:
headline:bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status
description: bcl-2 protein expression was characterized in a series of 58 astrocytomas from 21 pediatric and 37 adult patients. As part of a continuing attempt to define relevant prognostic factors which may predict clinical outcome, we have determined the impact of bcl-2 accumulation in malignant astrocytes on the length of patient survival. Aberrant overexpression of bcl-2 protein in tumor cells was detected in 57% (12 of 21) of pediatric and 73% (27 of 37) of the adult cases. Among pediatric patients, the median survival in months showed no relationship with the incidence of bcl-2-positive tumors. Among the adult patients, a favorable prognostic indicator was low-tumor grade (P = 0.05). bcl-2-positive tumors occurred with similar frequencies in WHO grades III and IV of malignancy. When bcl-2 expression in tumor cells was tested as a variable to predict for patient survival, the 6 patients without bcl-2 expression among 23 adult patients with grade IV tumors had a shorter median survival. The same 58 tumors had been previously analyzed for alterations of p53: 4 pediatric and 16 adult tumors had p53 gene mutations. There was no significant difference in median survival related to p53 gene status. There was no relationship between bcl-2 expression and p53 gene status: approximately equal numbers of tumors with either wild-type or mutant p53 were bcl-2 negative or bcl-2 positive. bcl-2 expression is high (40–100%) among other tumors of the central nervous system which also show low malignant potential. Up-regulation of bcl-2 in malignant astrocytes or constitutive expression in some tumor types may be a factor leading to a more favorable clinical outcome.
datePublished:
dateModified:
pageStart:369
pageEnd:375
sameAs:https://doi.org/10.1007/s004010050721
keywords:
Key words bcl-2
Astrocytomas
Survival
p53 tumor suppressor gene
Prognosis
Pathology
Neurosciences
image:
isPartOf:
name:Acta Neuropathologica
issn:
1432-0533
0001-6322
volumeNumber:94
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:E. W. Newcomb
affiliation:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
type:Organization
type:Person
name:Sandhya K. Bhalla
affiliation:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
type:Person
name:Clarissa L. Parrish
affiliation:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
type:Organization
type:Person
name:Roberta L. Hayes
affiliation:
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA
address:
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA, , IS
type:PostalAddress
type:Organization
type:Person
name:Henry Cohen
affiliation:
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA
address:
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
type:Person
name:Douglas C. Miller
affiliation:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status
description: bcl-2 protein expression was characterized in a series of 58 astrocytomas from 21 pediatric and 37 adult patients. As part of a continuing attempt to define relevant prognostic factors which may predict clinical outcome, we have determined the impact of bcl-2 accumulation in malignant astrocytes on the length of patient survival. Aberrant overexpression of bcl-2 protein in tumor cells was detected in 57% (12 of 21) of pediatric and 73% (27 of 37) of the adult cases. Among pediatric patients, the median survival in months showed no relationship with the incidence of bcl-2-positive tumors. Among the adult patients, a favorable prognostic indicator was low-tumor grade (P = 0.05). bcl-2-positive tumors occurred with similar frequencies in WHO grades III and IV of malignancy. When bcl-2 expression in tumor cells was tested as a variable to predict for patient survival, the 6 patients without bcl-2 expression among 23 adult patients with grade IV tumors had a shorter median survival. The same 58 tumors had been previously analyzed for alterations of p53: 4 pediatric and 16 adult tumors had p53 gene mutations. There was no significant difference in median survival related to p53 gene status. There was no relationship between bcl-2 expression and p53 gene status: approximately equal numbers of tumors with either wild-type or mutant p53 were bcl-2 negative or bcl-2 positive. bcl-2 expression is high (40–100%) among other tumors of the central nervous system which also show low malignant potential. Up-regulation of bcl-2 in malignant astrocytes or constitutive expression in some tumor types may be a factor leading to a more favorable clinical outcome.
datePublished:
dateModified:
pageStart:369
pageEnd:375
sameAs:https://doi.org/10.1007/s004010050721
keywords:
Key words bcl-2
Astrocytomas
Survival
p53 tumor suppressor gene
Prognosis
Pathology
Neurosciences
image:
isPartOf:
name:Acta Neuropathologica
issn:
1432-0533
0001-6322
volumeNumber:94
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:E. W. Newcomb
affiliation:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
type:Organization
type:Person
name:Sandhya K. Bhalla
affiliation:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
type:Person
name:Clarissa L. Parrish
affiliation:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
type:Organization
type:Person
name:Roberta L. Hayes
affiliation:
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA
address:
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA, , IS
type:PostalAddress
type:Organization
type:Person
name:Henry Cohen
affiliation:
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA
address:
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
type:Person
name:Douglas C. Miller
affiliation:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Acta Neuropathologica
issn:
1432-0533
0001-6322
volumeNumber:94
Organization:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA
address:
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA, , IS
type:PostalAddress
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA
address:
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA, , US
type:PostalAddress
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:E. W. Newcomb
affiliation:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
type:Organization
name:Sandhya K. Bhalla
affiliation:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
name:Clarissa L. Parrish
affiliation:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211
address:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
type:PostalAddress
type:Organization
name:Roberta L. Hayes
affiliation:
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA
address:
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA, , IS
type:PostalAddress
type:Organization
name:Henry Cohen
affiliation:
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA
address:
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
name:Douglas C. Miller
affiliation:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA
address:
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
type:PostalAddress
type:Organization
PostalAddress:
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
name:New York University Medical Center and the Kaplan Cancer Center, 550 First Avenue, New York, NY 10016, USA Tel.: 1-212-263-8757; Fax: 1-212-263-8211, , US
name:Department of Medicine, Staten Island University Hospital, Nalitt Institute for Cancer, Staten Island, NY 10305, USA, , IS
name:Department of Environmental Medicine, New York University and General Clinical Research Center, New York, NY 10016, USA, , US
name:Division of Neuropathology, New York University Medical Center, New York, NY 10016, USA, , US
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(35)
- Find out how much https://www.springernature.com/gp/authors earns monthly
- What's https://link.springernature.com/home/'s gross income?
- How much does https://order.springer.com/public/cart pull in monthly?
- How much cash flow does https://submission.springernature.com/new-submission/401/3 have monthly?
- How much revenue does https://www.springernature.com/gp/librarians/licensing/agc/journals bring in?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=E.%20W.%20Newcomb pull in monthly?
- What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22E.%20W.%20Newcomb%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sandhya%20K.%20Bhalla?
- What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sandhya%20K.%20Bhalla%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Clarissa%20L.%20Parrish have?
- Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Clarissa%20L.%20Parrish%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
- Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Roberta%20L.%20Hayes
- Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Roberta%20L.%20Hayes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Henry%20Cohen
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Henry%20Cohen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
- Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Douglas%20C.%20Miller
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Douglas%20C.%20Miller%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
- Discover the revenue of https://s100.copyright.com/AppDispatchServlet?title=bcl-2%20protein%20expression%20in%20astrocytomas%20in%20relation%20to%20patient%20survival%20and%20p53%20gene%20status&author=E.%20W.%20Newcomb%20et%20al&contentID=10.1007%2Fs004010050721©right=Springer-Verlag%20Berlin%20Heidelberg&publication=0001-6322&publicationDate=1997-09&publisherName=SpringerNature&orderBeanReset=true
- How much does https://citation-needed.springer.com/v2/references/10.1007/s004010050721?format=refman&flavour=citation generate monthly?
- How much does https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral net monthly?
- How much money does https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research make?
- How much income does https://www.springernature.com/gp/products have?
- Earnings of https://www.springernature.com/gp/librarians
- Explore the financials of https://www.springernature.com/gp/societies
- What are the total earnings of https://www.springernature.com/gp/partners?
- Find out how much https://www.springer.com/ earns monthly
- How much does https://www.nature.com/ earn?
- See how much https://www.biomedcentral.com/ makes per month
- Financial intake of https://www.palgrave.com/
- How much does https://www.apress.com/ gross monthly?
- How much profit does https://www.springernature.com/gp/legal/ccpa generate?
- Monthly income for https://www.springernature.com/gp/info/accessibility
- What are the earnings of https://support.springernature.com/en/support/home?
- Revenue of https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations
- What are the earnings of https://www.springernature.com/?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
CDN Services {📦}
- Crossref